241799-10-0
Chemical Structure
Zoniporide dihydrochloride
Synonym(s): CP-597396 dihydrochloride
- CAS No.: 241799-10-0
- Formula:C17H18Cl2N6O
- Molecular Weight:393.27
IUPAC Name: N-carbamimidoyl-5-cyclopropyl-1-(quinolin-5-yl)-1H-pyrazole-4-carboxamide dihydrochloride
InChIKey: ARZNPJAGKWHEHT-UHFFFAOYSA-N
SMILES: N=C(N)NC(C1=C(C2CC2)N(C3=C4C(N=CC=C4)=CC=C3)N=C1)=O.[H]Cl.[H]Cl
Biological Activity: Zoniporide dihydrochloride (CP-597396 dihydrochloride) is a potent and selective inhibitor of highly water-soluble sodium hydrogen exchange type 1 (NHE-1). Zoniporide dihydrochloride inhibits NHE1 dependent 22Na+ uptake in vitro with an IC50 of 14 nM. Zoniporide has antitumor activity[1][2].
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Zoniporide dihydrochloride | Zoniporide dihydrochloride (CP-597396 dihydrochloride) is a potent and selective inhibitor of highly water-soluble sodium hydrogen exchange type 1 (NHE-1). Zoniporide dihydrochloride inhibits NHE1 dependent 22Na+ uptake in vitro with an IC50 of 14 nM. Zoniporide has antitumor activity. | |||||||||||||||||||||
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- [1]. Marala RB, et al. Zoniporide: a potent and highly selective inhibitor of human Na(+)/H(+) exchanger-1. Eur J Pharmacol. 2002 Sep 6;451(1):37-41. [Content Brief]
- [2]. Sanhueza C, et al. Sodium/proton exchanger isoform 1 regulates intracellular pH and cell proliferation in human ovarian cancer. Biochim Biophys Acta Mol Basis Dis. 2017 Jan;1863(1):81-91. [Content Brief]
Keywords
