Zoniporide hydrochloride hydrate (Standard)
Zoniporide hydrochloride hydrate (Standard) (CP-597396 hydrochloride hydrate (Standard)) is the analytical standard of Zoniporide hydrochloride hydrate (HY-105064D). This product is intended for research and analytical applications. Zoniporide hydrochloride hydrate (CP-597396 hydrochloride hydrate) is a selective Na+/H+ exchanger subtype 1 (NHE1) inhibitor with cardioprotective activity, with IC50 values of 67 nM and 73 nM against rat NHE1. Zoniporide hydrochloride hydrate reduces intracellular Na+ and Ca2+ overload, preserves mitochondrial integrity, activates pro-survival ERK1/2 and STAT3 signaling pathways, reduces necrosis and apoptosis, and decreases neutrophil aggregation. Zoniporide hydrochloride hydrate is applicable to research related to myocardial ischemia-reperfusion injury and heart graft ischemia-reperfusion injury.
For research use only. We do not sell to patients.
- CAS No.: 863406-85-3
- Formula: C17H19ClN6O2
- Molecular Weight:374.82
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
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HY-105064D
Zoniporide hydrochloride hydrate -
HY-139313
NHE3-IN-2 -
HY-100302
FR183998 free base -
HY-100325
NHE3-IN-1 -
HY-19693
Cariporide -
HY-15991
Tenapanor -
HY-105064
Zoniporide -
HY-100302R
FR183998 free base (Standard) -
HY-132181
Dimethylamiloride hydrochloride -
HY-15991A
Tenapanor hydrochloride -
HY-19273
Rimeporide -
HY-106150B
Eniporide hydrochloride
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 863406-85-3
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Molecular Weight 374.82
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Formula C17H19ClN6O2
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SMILES
O=C(C1=C(C2CC2)N(C3=C4C=CC=NC4=CC=C3)N=C1)NC(N)=N.[H]Cl.[H]O[H]
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Synonyms
CP-597396 hydrochloride hydrate (Standard)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[2]. Marala RB, et al. Zoniporide: a potent and highly selective inhibitor of human Na(+)/H(+) exchanger-1. European journal of pharmacology. 2002 Sep 06;451(1):37-41. [Content Brief]
[3]. Guzman-Perez A, et al. Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility. Bioorganic & medicinal chemistry letters. 2001 Mar 26;11(6):803-7. [Content Brief]
[5]. Watson AJ, et al. Enhanced preservation of pig cardiac allografts by combining erythropoietin with glyceryl trinitrate and zoniporide. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2013 Jul;13(7):1676-87. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Zoniporide hydrochloride hydrate (Standard) Related Classifications
HY-105064DR Related Classifications
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Keywords
- Zoniporide hydrochloride hydrate (Standard)
- 863406-85-3
- CP-597396 hydrochloride hydrate (Standard)
- Reference Standards
- Na+/H+ Exchanger (NHE)
- ERK
- STAT
- Apoptosis
- rat NHE-3
- ERK1/2
- STAT3
- PS120 fibroblast cells
- myocardial ischemia-reperfusion injury
- human NHE-2
- rat NHE1
- cardiac allografts
- Na+/H+ exchanger isoform 1
- adult rat ventricular myocytes
- Inhibitor
- inhibitor
- inhibit