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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
phenylglyoxal unit
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "phenylglyoxal unit" in MCE Product Catalog:
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Research Areas:
2,2-Dihydroxy-1-phenylethan-1-one (Phenylglyoxal hydrate) is a phenylglyoxal-based, antioxidant drug synthesis intermediate. 2,2-Dihydroxy-1-phenylethan-1-one serves as a starting material for the synthesis of aromatic amines or aliphatic amines. It can be used to synthesize polysubstituted pyrrolo[3,2-c]pyridin-4-one derivatives, and also acts as a key structural unit in the microwave-assisted cascade synthesis of substituted 2-methyl-7-aryl-6H-thiazoloindole compounds .
Cat. No.: HY-D3102
CAS No.: 1015251-87-2
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CGTDP is a fluorescent probe used for selective labeling of active-site arginine residues, detection of local polarity, and monitoring of conformational changes in enzyme active sites. CGTDP contains a neutral red moiety serving as a polarity-sensitive fluorophore, and a phenylglyoxal unit acting as an arginine-specific labeling group; it undergoes a selective reaction via its α-dicarbonyl moiety with the guanidyl group of arginine residues in enzyme active sites to form a covalent linkage, thereby enabling the reporting of the local microenvironment at the labeled site. The excitation/emission wavelengths are Ex/Em = 398/607 nm and Ex/Em = 507/607 nm; these wavelengths blue-shift in organic solvents, such as Ex/Em = 375/569 nm and Ex/Em = 469/569 nm in THF, and Ex/Em = 375/587 nm and Ex/Em = 470/587 nm in acetonitrile. When labeled onto creatine kinase, its excitation/emission wavelengths are Ex/Em = 493/590 nm .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
