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polyunsaturated fatty acids

" in MedChemExpress (MCE) Product Catalog:

51

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6

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18

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6

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3

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Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-109590
    Arachidonic acid

    Immunocytophyt

    		 Endogenous Metabolite Cardiovascular Disease Inflammation/Immunology
    Arachidonic acid (Immunocytophyt) is a polyunsaturated omega-6 fatty acid and a major constituent of biomembranes. Arachidonic acid also acts as the substrate for various lipid mediators, such as prostaglandins (PGs). Arachidonic acid improves cognitive response and cardiovascular function .
    Arachidonic acid
  • HY-N0729
    Linoleic acid
    20+ Cited Publications

    		 Environmental Pollutants Endogenous Metabolite Cardiovascular Disease Metabolic Disease Cancer
    Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism .
    Linoleic acid
  • HY-B0660
    Eicosapentaenoic Acid
    Maximum Cited Publications
    30 Publications Verification

    EPA; Timnodonic acid

    		 Endogenous Metabolite Histone Demethylase Neurological Disease Cancer
    Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation .
    Eicosapentaenoic Acid
  • HY-N5134
    5'-Guanylic acid
    2 Publications Verification

    5'-GMP; 5'-guanosine monophosphate

    		 Endogenous Metabolite iGluR Neurological Disease Metabolic Disease
    5'-Guanylic acid is a purine nucleotide that participates in physiological processes such as energy metabolism, signal transduction, and gene expression regulation. 5'-Guanylic acid regulates the expression of genes related to fatty acid metabolism. 5'-Guanylic acid is the weak agonist for ionotropic glutamate receptors (iGluR), reduces the activity of the glutamatergic system and exhibits neuroprotective effect. 5'-Guanylic acid also causes neuronal cell death at high concentrations .
    5'-Guanylic acid
  • HY-N0121
    Sesamin
    10+ Cited Publications

    		 Stearoyl-CoA Desaturase (SCD) Neurological Disease
    Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia .
    Sesamin
  • HY-113130
    Eicosadienoic acid
    1 Publications Verification

    		 Endogenous Metabolite Metabolic Disease
    Eicosadienoic acid is a rare, naturally occurring n-6 polyunsaturated fatty acid found mainly in animal tissues .
    Eicosadienoic acid
  • HY-21268
    Methyl linolenate
    1 Publications Verification

    Linolenic acid methyl ester

    		 Environmental Pollutants Melatonin Receptor Metabolic Disease
    Methyl linolenate is a polyunsaturated fattly acid (PUFA). Methyl linolenate has an anti-melanogenesis activity with an IC50 of 60 μM. Methyl linolenate can also be used for studies of the mechanisms and prevention of oxidation/peroxidation of unsaturated fatty acids .
    Methyl linolenate
  • HY-W749411
    Malondialdehyde tetrabutylammonium

    		Biochemical Assay Reagents Endogenous Metabolite Others
    Malondialdehyde tetrabutylammonium is a quaternary ammonium salt formed by the decomposition of polyunsaturated fatty acids in plant cell membranes. Malondialdehyde tetrabutylammonium can be used for the quantification of malondialdehyde, a biomarker of lipid peroxidation .
    Malondialdehyde tetrabutylammonium
  • HY-W010970
    5'-Guanylic acid disodium salt
    2 Publications Verification

    5'-GMP disodium salt; 5'-guanosine monophosphate disodium salt

    		 Endogenous Metabolite iGluR Neurological Disease Metabolic Disease
    5'-Guanylic acid disodium salt is the disodium salt form of 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid disodium salt is a purine nucleotide that participates in physiological processes such as energy metabolism, signal transduction, and gene expression regulation. 5'-Guanylic acid disodium salt regulates the expression of genes related to fatty acid metabolism. 5'-Guanylic acid disodium salt is the weak agonist for ionotropic glutamate receptors (iGluR), reduces the activity of the glutamatergic system and exhibits neuroprotective effect. 5'-Guanylic acid disodium salt also causes neuronal cell death at high concentrations .
    5'-Guanylic acid disodium salt
  • HY-109590A
    Arachidonic acid sodium salt
    Maximum Cited Publications
    55 Publications Verification

    Immunocytophyt sodium salt

    		 Endogenous Metabolite Cardiovascular Disease Neurological Disease Inflammation/Immunology
    Arachidonic acid (Immunocytophyt) sodium salt is a polyunsaturated omega-6 fatty acid and a major constituent of biomembranes. Arachidonic acid sodium salt also acts as the substrate for various lipid mediators, such as prostaglandins (PGs). Arachidonic acid sodium salt improves cognitive response and cardiovascular function .
    Arachidonic acid sodium salt
  • HY-108750
    Soybean oil
    1 Publications Verification

    VT 18 (oil); Vegetoil; Wesson

    		 Environmental Pollutants Cardiovascular Disease
    Soybean oil (VT 18 (oil); Vegetoil; Wesson) is an edible vegetable oil. Soybean oil reduces circulating blood cholesterol levels when it replaces dietary saturated fats. Soybean oil does not affect inflammatory biomarkers or increase oxidative stress. Soybean oil contains γ-tocopherol and δ-tocopherol, which possess antioxidant properties. Soybean oil can be used in research related to coronary heart disease .
    Soybean oil
  • HY-Y1887
    Cottonseed oil

    		Environmental Pollutants Biochemical Assay Reagents Insecticide Cardiovascular Disease Infection Inflammation/Immunology
    Cottonseed oil is an edible oil extracted from the seeds of cotton (Gossypium hirsutum). Its fatty acid composition includes 26-35% saturated fatty acids, 42-52% polyunsaturated fatty acids, and 18-24% monounsaturated fatty acids. Cottonseed oil is regarded as an Insecticide, as it is used to protect the trunks of apple trees from damage by the apple clearwing moth. Cottonseed oil possesses anti-inflammatory and cardioprotective properties. It also has extensive applications in many fields such as biofuels, animal husbandry, cosmetics, agriculture, and chemical industry .
    Cottonseed oil
  • HY-131897
    1-Stearoyl-2-arachidonoyl-sn-glycerol
    1 Publications Verification

    		 PKC TRP Channel Endogenous Metabolite Neurological Disease
    1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment nonselective cation channel (NSCC) activity .
    1-Stearoyl-2-arachidonoyl-sn-glycerol
  • HY-N0729D
    Linoleic acid,suitable for cell culture

    		Glutathione Peroxidase SOD Cardiovascular Disease
    Linoleic acid is a critical component of polyunsaturated fatty acids. Linoleic acid reduces GSH-PX and T-SOD activities. Linoleic acid functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid can cause acute oxidative damage to red blood cells, ultimately leading to partial acute anemia. Linoleic acid can be used in the research of skin diseases associated with linoleic acid deficiency .
    Linoleic acid,suitable for cell culture
  • HY-139066
    Punicic acid
    1 Publications Verification

    Trichosanic acid

    		 TNF Receptor GLUT Proteasome Tau Protein PKC Neurological Disease Metabolic Disease Inflammation/Immunology
    Punicic acid is a bioactive compound of pomegranate seed oil. Punicic acid is an isomer of conjugated α-linolenic acid and ω-5 polyunsaturated fatty acids. Punicic acid has anti-inflammatory and antioxidant activities and can inhibit the expression of inflammatory mediators such as tumor necrosis factor α (TNF-α). Punicic acid can also reduce the formation of β-amyloid deposits and hyperphosphorylation of tau by increasing the expression of GLUT4 protein and inhibiting the overactivation of calpain, and is used to prevent and treat neurodegenerative diseases. In addition, punicic acid also has breast cancer inhibitor properties that depend on lipid peroxidation and PKC pathways .
    Punicic acid
  • HY-W089800
    trans-2-Nonenal

    trans-2-Nonen-1-al

    		 COX Lipoxygenase Apoptosis Cardiovascular Disease Inflammation/Immunology
    trans-2-Nonenal (trans-2-Nonen-1-al) is an endogenous peroxidation product of polyunsaturated fatty acids, acting as an inhibitor of COX and 12-LOX, as well as an inducer of apoptosis. trans-2-Nonenal is also a malodorous compound secreted by the human body, and its content gradually increases with aging. trans-2-Nonenal inhibits the activities of multiple enzymes such as platelet membrane-bound PTPase, preferentially covalently modifies proteins at lysine residues to form immunogenic adducts, and regulates platelet Arachidonic acid (HY-109590) metabolism. trans-2-Nonenal also exhibits significant cytotoxicity, reduces the viability of keratinocytes, promotes their apoptosis, and effectively decreases the thickness of epidermal models and the number of proliferating cells. trans-2-Nonenal is commonly used in studies of thrombotic, atherosclerotic diseases, renal adenocarcinoma, etc. .
    trans-2-Nonenal
  • HY-139285
    Arachidonic acid-alkyne

    		Endogenous Metabolite Metabolic Disease
    Arachidonic acid-alkyne is aω‑alkynyl lipid surrogates for polyunsaturated fatty acid. Arachidonic acid-alkyne has low rates of oxidation. Arachidonic acid-alkyne can be used for tracking the polyunsaturated fatty acids .
    Arachidonic acid-alkyne
  • HY-125139
    omega-3 Arachidonic acid ethyl ester, in ethanol, 98%

    ω-3 Arachidonic acid ethyl ester, in ethanol, 98%; (all-Z)-8,11,14,17-Eicosatetraenoic acid ethyl ester, in ethanol, 98%

    		 Biochemical Assay Reagents Cardiovascular Disease Others
    omega-3 Arachidonic acid ethyl ester, in ethanol, 98% is a rare polyunsaturated fatty acid found in very small amounts in dietary sources. Omega-3 fatty acids are known to be essential for the growth and development of infants, and they protect against heart disease, blood clots, high blood pressure, and inflammatory and autoimmune diseases. In human platelet membranes, omega-3 arachidonic acid inhibits arachidonyl-CoA synthetase with a Ki of 14 μM. It also inhibits arachidonoyl-CoA synthetase in calf brain extract with an IC50 of approximately 5 μM. Omega-3 ethyl arachidonate is the more lipophilic form of the free acid.
    omega-3 Arachidonic acid ethyl ester, in ethanol, 98%
  • HY-B0660R
    Eicosapentaenoic Acid (Standard)

    EPA (Standard); Timnodonic acid (Standard)

    		 Reference Standards Endogenous Metabolite Histone Demethylase Neurological Disease Cancer
    Eicosapentaenoic Acid (Standard) is the analytical standard of Eicosapentaenoic Acid. This product is intended for research and analytical applications. Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation .
    Eicosapentaenoic Acid (Standard)
  • HY-P2976
    Lipoxygenase, general

    LOX

    		 Endogenous Metabolite Others
    Lipoxygenase, general (LOX) is a dioxygenase, is often used in biochemical studies. Lipoxygenase, general catalyzes the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid .
    Lipoxygenase, general
  • HY-135298
    Soya fatty acids

    		Environmental Pollutants Metabolic Disease
    Soya fatty acids is a class of polyunsaturated fatty acids extracted from soybean .
    Soya fatty acids
  • HY-158812
    Eicosapentaenoyl-L-carnitine chloride

    		Drug Derivative Metabolic Disease
    Eicosapentaenoyl-L-carnitine chloride is a long-chain acylcarnitine composed of Eicosapentaenoic Acid (HY-B0660) and L-Carnitine (HY-B0399). The levels of Eicosapentaenoyl-L-carnitine chloride are increased in the eyes of mice fed a diet high in n-3/n-6 polyunsaturated fatty acids (PUFAs) in a mouse model of myopia induced by out-of-focus lenses .
    Eicosapentaenoyl-L-carnitine chloride
  • HY-W744867
    Pinolenic acid methyl ester

    		Biochemical Assay Reagents Others
    Pinolenic acid methyl ester is the methylated product of pinolenic acid, which can be used for the analysis of fatty acid content .
    Pinolenic acid methyl ester
  • HY-120987
    Ethyl stearidonate

    		Biochemical Assay Reagents Others
    6,9,12,15-octadecatetraenoic acid (Glycerol α-monoelaidate) is a rare omega-3 series polyunsaturated fatty acid. In normal people, it accounts for less than 0.25% of serum phospholipid fatty acids. It is found in certain natural oils, such as echium and blackcurrant, and to the extent that these oils are incorporated into nutraceuticals, stearidonic acid can be an important polyunsaturated species in the human diet. Ethyl stearidonic acid, an ester of the free acid, is less water soluble but more suitable for formulating stearidonic acid-containing diets and dietary supplements.
    Ethyl stearidonate
  • HY-120958
    Nisinic acid

    C24:6n-3

    		 Endogenous Metabolite Metabolic Disease
    Nisinic acid (C24:6n-3) is a very long chain polyunsaturated fatty acid (VLCPUFA) that is a component of triglycerides and cholesterol esters in mouse and rat testis .
    Nisinic acid
  • HY-135808
    BIZ 114

    		NF-κB Inflammation/Immunology
    BIZ 114 (Example 11) is a fatty acid derivative and potent inhibits the TNF-α activated NF-κΒ pathway. BIZ 114 has the potential to prevent and / or treat ophthalmic disorders such as retinal degenerative disorders and ocular inflammatory diseases .
    BIZ 114
  • HY-126720
    N-Lignoceroyl Taurine

    		Endogenous Metabolite Metabolic Disease
    N-Lignoceroyl Taurine is an arachidonoyl amino acid and taurine conjugate with a fatty acid that can be isolated from bovine brain. N-Lignoceroyl Taurine is one of several novel taurine-conjugated fatty acids discovered during mass spectrometry lipidomic analysis of the brain and spinal cord of wild-type and fatty acid amide hydrolase (FAAH) knockout mice. N-Lignoceroyl Taurine levels were 23-26-fold higher in FAAH -/- mice compared to wild-type mice, suggesting that FAAH utilizes N-Lignoceroyl Taurine as a substrate. However, in vitro experiments with purified FAAH showed that N-Lignoceroyl Taurine was hydrolyzed 2,000-fold slower in FAAH compared to oleoylethanolamide. N-Acyl Taurines with polyunsaturated acyl chains can activate members of the transient receptor potential (TRP) calcium channel family, including TRPV1 and TRPV4.
    N-Lignoceroyl Taurine
  • HY-117057S
    Hexaenoic acid-d6

    		Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease
    Hexaenoic acid-d6 is deuterium labeled Hexaenoic acid. Very long chain polyunsaturated fatty acids (VLCPUFAs) are important components of ceramides and sphingomyelin and are present in retina, sperm, and brain. Tetratriaconta-16(Z),19(Z),22(Z),25(Z),28(Z),31(Z)-hexaenoic acid is a C34:6 VLCPUFA whose specific biological actions are largely unknown. This VLCPUFA, along with others, has been investigated for its role in activating protein kinase C .
    Hexaenoic acid-d6
  • HY-W011269
    Eicosapentaenoic Acid sodium
    Maximum Cited Publications
    30 Publications Verification

    EPA sodium; Timnodonic acid sodium

    		 Endogenous Metabolite Histone Demethylase Cardiovascular Disease Metabolic Disease Cancer
    Eicosapentaenoic Acid (EPA)sodium is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid sodium exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid sodium activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid sodium can promote relaxation of vascular smooth muscle cells and vasodilation .
    Eicosapentaenoic Acid sodium
  • HY-122504
    Linoleoyl glycine

    		Potassium Channel Neurological Disease
    Linoleoyl glycine is a modified polyunsaturated fatty acid. Linoleoyl glycine has activating effects on human KCNQ1/KCNE1 (hKCNQ1/hKCNE1) channels expressed in Xenopus oocytes .
    Linoleoyl glycine
  • HY-127023
    Eicosapentaenoyl serotonin

    EPA-5-HT

    		 Endogenous Metabolite FAAH Interleukin Related Tyrosine Hydroxylase Metabolic Disease
    Eicosapentaenoyl serotonin (EPA-5-HT) is an endogenous fatty acid-serotonin conjugate lipid mediator. Eicosapentaenoyl serotonin acts as an inhibitor of fatty acid amide hydrolase (FAAH). Eicosapentaenoyl serotonin suppresses IL-17 release in Concanavalin A (HY-P2149)-stimulated human peripheral blood mononuclear cells. Eicosapentaenoyl serotonin is regulated by polyunsaturated fatty acids and modulates intestinal immunity and Th17 signaling. Eicosapentaenoyl serotonin can be used for the study of inflammatory bowel disease-related mechanisms .
    Eicosapentaenoyl serotonin
  • HY-147335
    6,9,12,15-Hexadecatetraenoic acid-ethyl ester

    		Endogenous Metabolite Cardiovascular Disease
    6,9,12,15-Hexadecatetraenoic acid-ethyl ester is an orally active n-1PUFA. 6,9,12,15-Hexadecatetraenoic acid-ethyl ester intake can reduce plasma triglyceride content in mice .
    6,9,12,15-Hexadecatetraenoic acid-ethyl ester
  • HY-N0121R
    Sesamin (Standard)

    		Stearoyl-CoA Desaturase (SCD) Reference Standards Neurological Disease
    Sesamin (Standard) is the analytical standard of Sesamin. This product is intended for research and analytical applications. Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia .
    Sesamin (Standard)
  • HY-165078
    (±)11(12)-EpETE

    (±)11,12-EEQ; (±)11,12-Epoxyeicosatetraenoic acid

    		 Endogenous Metabolite Others
    (±)11(12)-EpETE ((±)11,12-EEQ) is an EPA hydroxyl product. EPA is a major component of Omega-3 polyunsaturated fatty acids (PUFAs) .
    (±)11(12)-EpETE
  • HY-116722
    (2E)-4-Hydroperoxy-2-nonenal

    		Reactive Oxygen Species (ROS) Inflammation/Immunology
    (2E)-4-Hydroperoxy-2-nonenal is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids, and can be used as a marker of oxidative stress .
    (2E)-4-Hydroperoxy-2-nonenal
  • HY-21268S
    Methyl linolenate-13C18

    Linolenic acid methyl ester-13C18

    		 Isotope-Labeled Compounds Others
    Methyl linolenate- 13C18 is the 13C labeled Methyl linolenate . Methyl linolenate is a polyunsaturated fattly acid (PUFA). It is used in studies on the mechanisms and prevention of oxidation/peroxidation of unsaturated fatty acids . The IC50 is 60 uM .
    Methyl linolenate-13C18
  • HY-W346639
    4(Z),7(Z),10(Z),13(Z)-Hexadecatetraenoic acid methyl ester

    		Endogenous Metabolite Cancer
    4(Z),7(Z),10(Z),13(Z)-Hexadecatetraenoic acid methyl ester is a type of polyunsaturated fatty acid ester that can be used in cancer research .
    4(Z),7(Z),10(Z),13(Z)-Hexadecatetraenoic acid methyl ester
  • HY-113130R
    Eicosadienoic acid (Standard)

    		Endogenous Metabolite Reference Standards Metabolic Disease
    Eicosadienoic acid (Standard) is the analytical standard of Eicosadienoic acid. This product is intended for research and analytical applications. Eicosadienoic acid is a rare, naturally occurring n-6 polyunsaturated fatty acid found mainly in animal tissues .
    Eicosadienoic acid (Standard)
  • HY-W744883
    Methyl-d3 Linolenate

    		Isotope-Labeled Compounds Melatonin Receptor Metabolic Disease
    Methyl-d3 Linolenate is the deuterium labeled Methyl linolenate (HY-21268). Methyl linolenate is a polyunsaturated fattly acid (PUFA). Methyl linolenate has an anti-melanogenesis activity with an IC50 of 60 μM. Methyl linolenate can also be used for studies of the mechanisms and prevention of oxidation/peroxidation of unsaturated fatty acids .
    Methyl-d3 Linolenate
  • HY-N0121S
    Sesamin-d8

    		Isotope-Labeled Compounds Neurological Disease
    Sesamin-d8 is the deuterium labeled Sesamin (HY-N0121). Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia .
    Sesamin-d8
  • HY-117057
    Hexaenoic acid

    		Endogenous Metabolite Metabolic Disease
    Very long chain polyunsaturated fatty acids (VLCPUFAs) are important components of ceramides and sphingomyelin and are present in retina, sperm, and brain. Tetratriaconta-16(Z),19(Z),22(Z),25(Z),28(Z),31(Z)-hexaenoic acid is a C34:6 VLCPUFA whose specific biological actions are largely unknown. This VLCPUFA, along with others, has been investigated for its role in activating protein kinase C.
    Hexaenoic acid
  • HY-122129
    Dotriaconta-14,17,20,23,26,29-hexaenoic acid

    		Endogenous Metabolite Metabolic Disease
    Very long chain polyunsaturated fatty acids (VLCPUFA) are present in retina, sperm, and brain. Though little is known of their biosynthesis or functional roles in these tissues, recent studies using the elongation of very long-chain FA-4 protein suggest a unique role for VLCPUFA in retinal development and macular degeneration. Dotriaconta-14,17,20,23,26,29-hexaenoic acid is a C32:6 VLCPUFA whose specific biological actions are largely unknown, but are thought to involve normal photoreceptor cell function in the retina.
    Dotriaconta-14,17,20,23,26,29-hexaenoic acid
  • HY-131897S
    1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol

    		Isotope-Labeled Compounds PKC TRP Channel Endogenous Metabolite Neurological Disease
    1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol is the deuterium labeled 1-Stearoyl-2-arachidonoyl-sn-glycerol. 1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment nonselective cation channel (NSCC) activity .
    1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol
  • HY-122129S
    Dotriaconta-14,17,20,23,26,29-hexaenoic acid-d6

    		Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease
    Dotriaconta-14,17,20,23,26,29-hexaenoic acid-d6 is deuterium labeled Dotriaconta-14,17,20,23,26,29-hexaenoic acid. Very long chain polyunsaturated fatty acids (VLCPUFA) are present in retina, sperm, and brain. Though little is known of their biosynthesis or functional roles in these tissues, recent studies using the elongation of very long-chain FA-4 protein suggest a unique role for VLCPUFA in retinal development and macular degeneration. Dotriaconta-14,17,20,23,26,29-hexaenoic acid is a C32:6 VLCPUFA whose specific biological actions are largely unknown, but are thought to involve normal photoreceptor cell function in the retina .
    Dotriaconta-14,17,20,23,26,29-hexaenoic acid-d6
  • HY-B0660A
    Eicosapentaenoic acid metformin

    EPA metformin; Timnodonic acid metformin

    		 Endogenous Metabolite Histone Demethylase Neurological Disease Cancer
    Eicosapentaenoic Acid (EPA) metformin is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic acid metformin exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). EEicosapentaenoic acid metformin activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic acid metformin can promote relaxation of vascular smooth muscle cells and vasodilation .
    Eicosapentaenoic acid metformin
  • HY-Z11709
    13-Hydroxy-alpha-tocopherol

    		Endogenous Metabolite Cancer
    13-Hydroxy-alpha-tocopherol is a fat-soluble vitamin E derivative and anticancer agent with antioxidant and antiproliferative activities. 13-Hydroxy-alpha-tocopherol scavenges peroxyl free radicals and protects polyunsaturated fatty acids from oxidative damage. 13-Hydroxy-alpha-tocopherol not only inhibits the growth of glioma cancer cells, but its deficiency is also closely associated with recurrent miscarriage, embryonic growth retardation and death. Clinical observations show that the expression of 13-Hydroxy-alpha-tocopherol is downregulated in the follicular fluid of patients with recurrent miscarriage. 13-Hydroxy-alpha-tocopherol has important application potential in the research of recurrent miscarriage and glioma .
    13-Hydroxy-alpha-tocopherol
  • HY-N19728
    5,9-Tetracosadienoic acid

    		Biochemical Assay Reagents Others
    5,9-Tetracosadienoic acid is a long-chain polyunsaturated fatty acid with a Δ 5, 9 unsaturated structure .
    5,9-Tetracosadienoic acid
  • HY-W339816
    (S,R)-Bis(monomyristoylglycero)phosphate ammonium

    		Lipocalin Family Endogenous Metabolite Others
    (S,R)-Bis(monomyristoylglycero)phosphate ammonium actively contributes to cargo sorting by promoting the degradation and sorting of lipids, and it plays a critical role in the sorting of polyunsaturated fatty acids (PUFAs) within acidic organelles. This phospholipid features two phosphate-linked glycerol molecules arranged in a unique sn-1 glycerophospho-sn-1′ glycerol stereoconformation, with each glycerol molecule esterified to a myristic acid. Typically, it is found in the intraluminal vesicles (ILVs) of late endosomes and lysosomes.
    (S,R)-Bis(monomyristoylglycero)phosphate ammonium
  • HY-N19806
    8,11-Octadecadienoicacid, methyl ester

    		Drug Derivative Others
    8,11-Octadecadienoic acid, methyl ester is a polyunsaturated fatty acid methyl ester that can be extracted from castor seeds via direct ultrasonic transesterification .
    8,11-Octadecadienoicacid, methyl ester
  • HY-W923355
    1,2,3-Trieicosapentaenoyl glycerol

    EPA-TG; Glycerol trieicosapentaenoate; TG(20:5/20:5/20:5)

    		 Others Others
    1,2,3-Trieicosapentaenoyl glycerol (EPA-TG) is a glycerol ester that can be obtained by the reaction of polyunsaturated fatty acids or lower alkyl esters with glycerol catalyzed by alkoxide ions . After two intravenous injections of the EPA-TG emulsion into rabbits, the EPA content in plasma and platelet phospholipids increased markedly . In another study, by administering the EPA-TG emulsion, the production of leukotriene B4 by polymorphonuclear leukocytes in rabbits was reduced by 40% .
    1,2,3-Trieicosapentaenoyl glycerol

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