7 Results for "

prenylated isoflavone

" in MedChemExpress (MCE) Product Catalog:
Products (7)

7 Results for "prenylated isoflavone" in MCE Product Catalog:

3
Wighteone
Wighteone
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3 Cited Publications
Cat. No.: HY-N1073
CAS No.: 51225-30-0
Synonyms: 6-Isopentenylgenistein; Erythrinin B
Category:  

Leguminosae Genista ephedroides DC. Plants Isoflavones

Target:  

Apoptosis EGFR HSP ERK Akt

Wighteone (6-Isopentenylgenistein; Erythrinin B) is a prenylated isoflavone that acts as a HSP90/EGFR L858R/T790M inhibitor and antifungal agent. Wighteone reduces the expression level of HSP90, blocks EGF-induced phosphorylation of EGFR, and thereby inhibits the downstream ERK and AKT signaling pathways. Wighteone induces cell cycle redistribution, inhibits proliferation and triggers apoptosis in cancer cells. Wighteone can be isolated from Erythrina suberosa, and can also be induced to synthesize in Lotus japonicus under specific conditions. Wighteone can be used to study HER2-positive breast cancer, leukemia, non-small cell lung cancer with EGFR L858R/T790M mutation, and fungal infections .
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6,8-Diprenylorobol
6,8-Diprenylorobol
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Cat. No.: HY-N2693
CAS No.: 66777-70-6
Category:  

Flavonoids Maclura tricuspidata Carriere Plants Moraceae Isoflavones

Target:  

Apoptosis Reactive Oxygen Species (ROS) Caspase Akt ERK JNK p38 MAPK Bcl-2 Family

6,8-Diprenylorobol, a prenylated isoflavone, is a nature product that could be isolated from the leaves of Cudrania tricuspidata. 6,8-Diprenylorobol antiproliferative effect and induces apoptosis through activation of p53 and generation of ROS .
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Flemiphilippinin A
Flemiphilippinin A
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Cat. No.: HY-N4316
CAS No.: 140366-64-9
Category:  

Flavonoids Leguminosae Flemingia philippinensis Merr. et Rolfe Phenols Polyphenols Plants Disease Research Fields Endocrinology Isoflavones

Target:  

Others

Flemiphilippinin A is a prenylated isoflavone that can be isolated from Flemingia philippinensis .
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Derrone
Derrone
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Cat. No.: HY-N3737
CAS No.: 76166-59-1
Category:  

Infection Flavonoids Monophenols Phenols Maclura pomifera (Raf.) Schneid. Plants Moraceae Disease Research Fields Isoflavones

Target:  

Aurora Kinase PERK Reactive Oxygen Species (ROS)

Derrone, a prenylated isoflavones, is an Aurora kinase inhibitor, with IC50 values of 6 and 22.3 μM against Aurora B and Aurora A, respectively. Derrone shows anti-tumor activity .
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Isolupalbigenin
Isolupalbigenin
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Cat. No.: HY-N8477
CAS No.: 162616-70-8
Category:  

Flavonoids Maclura tricuspidata Carriere Plants Moraceae Isoflavones

Target:  

NO Synthase

Isolupalbigenin is an inhibitor of NO. Isolupalbigenin has anti-proliferative activity on HL-60 cells with an IC50 of 5.1 μM .
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Erythrivarone A
Erythrivarone A
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Cat. No.: HY-N3743
CAS No.: 63807-90-9
Synonyms: Dihydroalpinumisoflavone
Category:  

Flavonoids Leguminosae Plants Erythrina variegata Linn. Isoflavones

Target:  

Others

Erythrivarone A is an isoflavone that can be isolated from the stem bark of Erythrina variegate .
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4'-O-Methylpreglabridin
4'-O-Methylpreglabridin
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Cat. No.: HY-N21812A
CAS No.: 105072-18-2
Category:  

Glycyrrhiza asymmetrica Hub.-Mor. Phenols Plants Fabaceae

Target:  

Drug Intermediate

4'-O-Methylpreglabridin is a prenylated isoflavone precursor of Glabridin (HY-N0393), and it can be converted into Glabridin via one-step oxidative cyclization catalyzed by GgOC family enzymes .
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