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receptor-gamma-t

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標的別:	ROR (5)
研究分野別:	Cancer (1) Inflammation/Immunology (5)

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製品番号	製品名	Target	研究分野	構造式

HY-132810

Bevurogant BI 730357	ROR	Inflammation/Immunology Cancer
Bevurogant (BI 730357) is a retinoid-related *orphan receptor-gamma t* (RORγt)** antagonist. Bevurogant can be used for the research of chronic inflammatory diseases .

HY-W150866

Hexyl 4-hydroxybenzoate Hexylparaben	ROR	Inflammation/Immunology
Hexyl 4-hydroxybenzoate (Hexylparaben) is a retinoic acid-related orphan receptor RORγ(t) agonist with an EC₅₀ of 144 nM. Hexyl 4-hydroxybenzoate is used in the study of autoimmune diseases .

HY-119366

S18-000003	ROR	Inflammation/Immunology
S18-000003 is a potent, selective and orally active inhibitor of *retinoic acid receptor-related orphan receptor-gamma-t* (RORγt), with an IC₅₀** of <30 nM towards human RORγt in competitive binding assays. S18-000003 shows selectivity for RORγt over other ROR family members (IC₅₀>10 μM). S18-000003 can be used for the research of psoriasis with low risk of thymic aberrations .

HY-133552

RORγt Inverse agonist 10	ROR	Inflammation/Immunology
RORγt Inverse agonist 10 is a potent and orally bioavailable RORγt (retinoic acid receptor-related orphan nuclear receptor gamma t) inverse agonist, with an IC₅₀ of 51 nM. RORγt is a major transcription factor of genes related to psoriasis pathogenesis such as IL-17A, IL-22, and IL-23R

HY-112863

RORγt inhibitor 3	ROR	Inflammation/Immunology
RORγt inhibitor 3 is an orally active and potent retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor. RORγt inhibitor 3 shows high binding affinity and inhibitory activity of Th17 cell differentiation. RORγt inhibitor 3 also shows efficacy in both mouse experimental autoimmune encephalomyelitis (EAE) and collagen induced arthritis (CIA) models .

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HY-P83758

	ROR gamma T Antibody (YA3559) IMD42 antibody; MGC129539 antibody; NR1F3 antibody; Nuclear receptor ROR gamma antibody; Nuclear receptor subfamily 1 group F member 3 antibody; RAR related orphan receptor C antibody; Retinoic acid binding receptor gamma antibody; Retinoid related orphan receptor gamma antibody; Rorc antibody; RORG antibody; RORG_HUMAN antibody; RZR gamma antibody; RZRG antibody; TOR antibody	WB, IHC-P	Human, Rat
	ROR gamma T Antibody (YA3559) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ROR gamma T.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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