RORγt inhibitor 3
RORγt inhibitor 3 is an orally active and potent retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor. RORγt inhibitor 3 shows high binding affinity and inhibitory activity of Th17 cell differentiation. RORγt inhibitor 3 also shows efficacy in both mouse experimental autoimmune encephalomyelitis (EAE) and collagen induced arthritis (CIA) models.
For research use only. We do not sell to patients.
- CAS No.: 1361413-10-6
- Formula: C26H20Cl2N2O4S2
- Molecular Weight:559.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
260 nM
Compound: 4
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Agonist activity at human pregnane X receptor expressed in HEK293 cells by luciferase reporter gene assay
Agonist activity at human pregnane X receptor expressed in HEK293 cells by luciferase reporter gene assay
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[PMID: 25305688] |
| Jurkat | EC50 |
10 nM
Compound: 55
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Activity at human RoRc in human Jurkat cells assessed as inhibition of IL-17 promoter
Activity at human RoRc in human Jurkat cells assessed as inhibition of IL-17 promoter
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[PMID: 24502334] |
| T-cell | EC50 |
158 nM
Compound: 55
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Activity at RoRc in mouse CD4+ T cells assessed as inhibition of IL-17 production
Activity at RoRc in mouse CD4+ T cells assessed as inhibition of IL-17 production
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[PMID: 24502334] |
Chemical Information
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CAS No. 1361413-10-6
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Molecular Weight 559.48
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Formula C26H20Cl2N2O4S2
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SMILES
O=C(C1=C(Cl)C=CC=C1)C2=C(C3=CC(Cl)=CC=C3)N=C(NC(CC4=CC=C(S(=O)(CC)=O)C=C4)=O)S2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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