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Cat. No.: HY-112863

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RORγt inhibitor 3

RORγt inhibitor 3 is an orally active and potent retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor. RORγt inhibitor 3 shows high binding affinity and inhibitory activity of Th17 cell differentiation. RORγt inhibitor 3 also shows efficacy in both mouse experimental autoimmune encephalomyelitis (EAE) and collagen induced arthritis (CIA) models.

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CAS No.: 1361413-10-6
Formule: C₂₆H₂₀Cl₂N₂O₄S₂
Masse moléculaire:559.48

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

RORγt inhibitor 3 Chemical Structure

CAS No.: 1361413-10-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform ROR :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	260 nM Compound: 4	Agonist activity at human pregnane X receptor expressed in HEK293 cells by luciferase reporter gene assay Agonist activity at human pregnane X receptor expressed in HEK293 cells by luciferase reporter gene assay	[PMID: 25305688]
Jurkat	EC₅₀	10 nM Compound: 55	Activity at human RoRc in human Jurkat cells assessed as inhibition of IL-17 promoter Activity at human RoRc in human Jurkat cells assessed as inhibition of IL-17 promoter	[PMID: 24502334]
T-cell	EC₅₀	158 nM Compound: 55	Activity at RoRc in mouse CD4+ T cells assessed as inhibition of IL-17 production Activity at RoRc in mouse CD4+ T cells assessed as inhibition of IL-17 production	[PMID: 24502334]

Chemical Information

CAS No. 1361413-10-6
Masse moléculaire 559.48
Formule C₂₆H₂₀Cl₂N₂O₄S₂
SMILES

O=C(C1=C(Cl)C=CC=C1)C2=C(C3=CC(Cl)=CC=C3)N=C(NC(CC4=CC=C(S(=O)(CC)=O)C=C4)=O)S2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Wang Y, et al. Discovery of novel N-(5-(arylcarbonyl)thiazol-2-yl)amides and N-(5-(arylcarbonyl)thiophen-2-yl)amides as potent RORγt inhibitors. Bioorg Med Chem. 2014 Jan 15;22(2):692-702. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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