22 Results for "

sortase

" in MedChemExpress (MCE) Product Catalog:
Products (22)

22 Results for "sortase" in MCE Product Catalog:

1
Sortase A, S. aureus
Sortase A, S. aureus
0 Images
1 Cited Publications
Art. -Nr.: HY-E70234
CAS. Nr.: 9033-39-0
Synonyms: SrtA
Target:  

Bacterial

Forschungsgebiete:  

Others

Sortase A, S. aureus (SrtA), a transpeptidase enzyme is present in many Gram-positive bacteria and helps in the recruitment of the cell surface proteins. Sortase A, S. aureus plays an important part in ligation of various molecules on the cell surfaces .
1
Rhodionin
Rhodionin
0 Images
1 Cited Publications
Art. -Nr.: HY-N0241
CAS. Nr.: 85571-15-9
Category:  

Flavonols Crassulaceae Metabolic Disease Plants Rhodiola crenulata (HK. f. et.Thoms) H. Ohba Flavonoids Rhodiola rosea Linn. Phenols Polyphenols Disease Research Fields

Target:  

Cholinesterase (ChE) Lipase Bacterial Cytochrome P450

Rhodionin is an orally active, multifunctional antivirulence and cytoprotective agent that targets and inhibits Lipase, sortase A (SrtA), CYP2D6 (IC50=0.761 μM), AChE (IC50=2.43-57.5 μM), and DPPH free radicals (IC50=19.49 μM). Rhodionin is isolable from the roots of Rhodiola crenulata. Rhodionin reduces postprandial serum triglyceride levels in mice by inhibiting lipase activity. Rhodionin also binds directly to SrtA to inhibit its transpeptidase activity, thereby reducing the fibrinogen adhesion and surface protein A levels of MRSA, effectively inhibiting biofilm formation and protecting against MRSA-induced cell damage. Rhodionin improves the survival rate of infected mice without affecting MRSA growth, and finds wide application in studies related to hyperlipidemia, exogenous obesity, and pneumonia induced by methicillin-resistant Staphylococcus aureus (MRSA) .
Bacterial Sortase Substrate III, Abz/DNP TFA
Bacterial Sortase Substrate III, Abz/DNP TFA
0 Images
Art. -Nr.: HY-P1883A
Target:  

Fluorescent Dye

Forschungsgebiete:  

Infection

Bacterial Sortase Substrate III, Abz/DNP TFA is a fluorescent peptide substrate. Bacterial Sortase Substrate III, Abz/DNP TFA undergoes cleavage catalyzed by Staphylococcus aureus sortase A (SrtAΔN24) and Streptococcus pyogenes sortase A (SrtAΔN81), and catalyzes the formation of an amide bond between the carboxyl group of threonine and the amino group of the cell wall cross-bridge. Cleavage of this substrate can be detected at Ex/Em=320 nm/420 nm .
Hibifolin
Hibifolin
0 Images
Art. -Nr.: HY-N7368
CAS. Nr.: 55366-56-8
Category:  

Flavonols other families Flavonoids Neurological Disease Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Adenosine Deaminase Bacterial Caspase

Hibifolin is a flavonol glycoside that can be isolated from Helicteres isora. Hibifolin is an inhibitor of adenosine deaminase (ADA) (Ki = 49.92 μM). Hibifolin protects neurons against β-amyloid-induced neurotoxicity. Hibifolin possesses a potent protective activity against cell death induced by aggregated Aβ. Hibifolin can abolish Aβ-induced caspase-3 and caspase-7 activation. Hibifolin induces Akt phosphorylation in cortical neurons. Hibifolin is also a natural sortase A (SrtA) inhibitor (IC50 = 31.2 μM) through direct binding to SrtA protein. Hibifolin attenuates the pathogenic behavior of Staphylococcus aureus including adhesion, invasion, and biofilm formation. Hibifolin improves the survival of pneumonia induced by Staphylococcus aureus in mouse model and alleviates pathological damage. Hibifolin shows a synergistic antibacterial effect with Cefotaxime (HY-A0088A) .
SmBiT Tag
SmBiT Tag
0 Images
Art. -Nr.: HY-P10633
CAS. Nr.: 1628913-44-9
Target:  

Amino Acid Derivatives

Forschungsgebiete:  

Others

SmBiT Tag is an 11-amino-acid short peptide with extremely low natural affinity for LgBiT, with a Kd value of approximately 190 μM. It serves as a core component of the NanoLuc Binary Technology (NanoBiT) system. NanoBiT is a bioluminescent reporter system based on protein fragment complementation technology, which is used to monitor dynamic protein-protein interactions in live cells and in vitro .
GGGYK-Biotin
GGGYK-Biotin
0 Images
Art. -Nr.: HY-P10620
Target:  

Bacterial

Forschungsgebiete:  

Others

GGGYK-Biotin is a substrate peptide designed to study the substrate specificity of Sortase A. GGGYK-Biotin can be used to develop Sortase A variants with different substrate specificities .
DABCYL-LPETG-EDANS
DABCYL-LPETG-EDANS
0 Images
Art. -Nr.: HY-P5481
CAS. Nr.: 1807943-24-3
Target:  

Peptides

Forschungsgebiete:  

Others

DABCYL-LPETG-EDANS is a biological active peptide. (This 5-amino acid peptide is a sortase substrate, C-terminal sorting signal. Sortase cleaves surface proteins at the LPXTG motif and catalyzes the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Sortases are a family of Gram-positive transpeptidases responsible for anchoring surface protein virulence factors to the peptidoglycan cell wall layer. Cleavage of this FRET substrate by sortase reveals the fluorescent signal, Abs/Em = 340/490 nm.)
Sortase A, S. aureus (non-Ca2+-dependent)
Sortase A, S. aureus (non-Ca2+-dependent)
0 Images
Art. -Nr.: HY-E70234A
Target:  

Bacterial

Forschungsgebiete:  

Infection Inflammation/Immunology

Sortase A, S. aureus (non-Ca 2+-dependent), a transpeptidase enzyme is present in many Gram-positive bacteria and helps in the recruitment of the cell surface proteins. Sortase A, S. aureus (non-Ca 2+-dependent) plays an important part in ligation of various molecules on the cell surfaces .
Dabcyl-QALPETGEE-Edans
Dabcyl-QALPETGEE-Edans
0 Images
Art. -Nr.: HY-P5485
CAS. Nr.: 271798-75-5
Target:  

Bacterial

Forschungsgebiete:  

Others

Dabcyl-QALPETGEE-Edans is a synthetic peptide substrate for fluorescence resonance energy transfer (FRET) detection of Sortase A (SrtA) enzymatic activity. Dabcyl-QALPETGEE-Edans is labeled at both ends with the fluorescent group Edans (donor) and the quencher Dabcyl (acceptor), respectively. Dabcyl-QALPETGEE-Edans's central sequence contains a conserved motif specifically recognized by SrtA. Dabcyl-QALPETGEE-Edans demonstrates high sensitivity in vitro assays, enabling precise determination of the half-maximal inhibitory concentration of SrtA .
5-FAM-LPETGG
5-FAM-LPETGG
0 Images
Art. -Nr.: HY-P10406
Target:  

Peptides

Forschungsgebiete:  

Others

5-FAM-LPETGG is a fluorescent sortase A substrate .
Bacterial Sortase Substrate III, Abz/DNP
Bacterial Sortase Substrate III, Abz/DNP
0 Images
Art. -Nr.: HY-P1883
CAS. Nr.: 2857862-12-3
Target:  

Fluorescent Dye

Forschungsgebiete:  

Infection

Bacterial Sortase Substrate III, Abz/DNP is a fluorescent peptide substrate. Bacterial Sortase Substrate III, Abz/DNP undergoes cleavage catalyzed by Staphylococcus aureus sortase A (SrtAΔN24) and Streptococcus pyogenes sortase A (SrtAΔN81), and catalyzes the formation of an amide bond between the carboxyl group of threonine and the amino group of the cell wall cross-bridge. Cleavage of this substrate can be detected at Ex/Em=320 nm/420 nm .
Efloxate
Efloxate
0 Images
Art. -Nr.: HY-B0930
CAS. Nr.: 119-41-5
Synonyms: Angorlisin
Target:  

Bacterial

Forschungsgebiete:  

Infection Cardiovascular Disease

Efloxate (Angorlisin) is a vasodilator used in the research of chronic coronary insufficiency and angina pectoris. Efloxate binds to Staphylococcus aureus sortase A .
SrtA-IN-1
SrtA-IN-1
0 Images
Art. -Nr.: HY-173219
Target:  

Bacterial

Forschungsgebiete:  

Infection

SrtA-IN-1 (Compound T10) is an inhibitor of Streptococcus pyogenes sortase A (SpSrtA), with an IC50 value of 0.7 μM. SrtA-IN-1 can be used in the research of the anti-infection field .
Nortrachelogenin-8'-O-β-glucoside
Nortrachelogenin-8'-O-β-glucoside
0 Images
Art. -Nr.: HY-N8805
CAS. Nr.: 858127-38-5
Category:  

Ranunculaceae Phenols Polyphenols Plants Pulsatilla cernua (Thunb.) Bercht. et Opiz.

Target:  

Others

Nortrachelogenin-8'-O-β-glucoside is a natural product that can be isolated from the dried roots of Pulsatilla koreana. Nortrachelogenin-8'-O-β-glucoside inhibits cancer cell proliferation and reduces hormone dependence .
SrtA-IN-2
SrtA-IN-2
0 Images
Art. -Nr.: HY-161124
Target:  

Bacterial

Forschungsgebiete:  

Infection

SrtA-IN-2 (compound Y40), a ML346 (HY-18669) analog, is a Sortase A (SrtA) inhibitor. SrtA-IN-2 shows inhibitory activity on Staphylococcus aureus SrtA and shows inhibitory effects on biofilm formation. SrtA-IN-2 is an antivirulence agent against S. aureus infections .
Sortase A (MS grade)
Sortase A (MS grade)
0 Images
Art. -Nr.: HY-E70234B
Target:  

Bacterial

Forschungsgebiete:  

Others

Sortase A (MS grade) is a transpeptidase of Staphylococcus aureus, which can perform site-specific cleavage or transpeptidation linkage by utilizing the LPXTG recognition sequence. Sortase A (MS grade) can be utilized in high-sensitivity mass spectrometry (MS) applications and chemical enzymatic protein labeling.
Hibifolin (Standard)
Hibifolin (Standard)
0 Images
Art. -Nr.: HY-N7368R
CAS. Nr.: 55366-56-8
Category:  

Flavonols other families Flavonoids Phenols Polyphenols Plants

Target:  

Reference Standards Adenosine Deaminase Bacterial Caspase

Hibifolin (Standard) is the analytical standard of Hibifolin. This product is intended for research and analytical applications. Hibifolin is a flavonol glycoside that can be isolated from Helicteres isora. Hibifolin is an inhibitor of adenosine deaminase (ADA) (Ki = 49.92 μM). Hibifolin protects neurons against β-amyloid-induced neurotoxicity. Hibifolin possesses a potent protective activity against cell death induced by aggregated Aβ. Hibifolin can abolish Aβ-induced caspase-3 and caspase-7 activation. Hibifolin induces Akt phosphorylation in cortical neurons. Hibifolin is also a natural sortase A (SrtA) inhibitor (IC50 = 31.2 μM) through direct binding to SrtA protein. Hibifolin attenuates the pathogenic behavior of Staphylococcus aureus including adhesion, invasion, and biofilm formation. Hibifolin improves the survival of pneumonia induced by Staphylococcus aureus in mouse model and alleviates pathological damage. Hibifolin shows a synergistic antibacterial effect with Cefotaxime (HY-A0088A) .
(7S,8R)-Dihydrodehydrodiconiferyl alcohol-9-β-D-glucopyranoside
(7S,8R)-Dihydrodehydrodiconiferyl alcohol-9-β-D-glucopyranoside
0 Images
Art. -Nr.: HY-N17584
CAS. Nr.: 126371-34-4
Category:  

Phenols Plants Compositae Achillea millefolium L.

Target:  

Bacterial

(7S,8R)-Dihydrodehydrodiconiferyl alcohol-9-β-D-glucopyranoside (compound 1) is a lignan found in the dried roots of Pulsatilla koreana and Sortase A inhibitor with an IC50 of 67.7 μM against Streptococcus mutans OMZ65 Sortase A. (7S,8R)-Dihydrodehydrodiconiferyl alcohol-9-β-D-glucopyranoside can be used for the research of dental caries .
Maltol-3-O-(4'-O-p-coumaroyl-6'-O-(3-hydroxy-3-methylglutaroyl))-β-glucopyranoside
Maltol-3-O-(4'-O-p-coumaroyl-6'-O-(3-hydroxy-3-methylglutaroyl))-β-glucopyranoside
0 Images
Art. -Nr.: HY-N20632
CAS. Nr.: 942503-47-1
Category:  

Monophenols Leguminosae Sophora japonica (L.) Schott Phenols Plants

Target:  

Bacterial

Maltol-3-O-(4'-O-p-coumaroyl-6'-O-(3-hydroxy-3-methylglutaroyl))-β-glucopyranoside is a sortase A inhibitor of Streptococcus mutans, with an IC50 value of 94.3 μM. Maltol-3-O-(4'-O-p-coumaroyl-6'-O-(3-hydroxy-3-methylglutaroyl))-β-glucopyranoside inhibits saliva-induced aggregation of Streptococcus mutans. Maltol-3-O-(4'-O-p-coumaroyl-6'-O-(3-hydroxy-3-methylglutaroyl))-β-glucopyranoside can be used in caries-related research .
(7S,8S)-Dihydrodehydrodiconiferyl alcohol 9’-β-D-glucopyranoside
(7S,8S)-Dihydrodehydrodiconiferyl alcohol 9’-β-D-glucopyranoside
0 Images
Art. -Nr.: HY-N17582
CAS. Nr.: 1526987-82-5
Category:  

Ranunculaceae Phenols Plants Pulsatilla cernua (Thunb.) Bercht. et Opiz.

Target:  

Bacterial

(7S,8S)-Dihydrodehydrodiconiferyl alcohol 9’-β-D-glucopyranoside is a Streptococcus mutans Sortase A inhibitor with an IC50 of 37.3 μM. (7S,8S)-Dihydrodehydrodiconiferyl alcohol 9’-β-D-glucopyranoside inhibits transpeptidase activity linked to Gram-positive bacterial surface protein anchoring. (7S,8S)-Dihydrodehydrodiconiferyl alcohol 9’-β-D-glucopyranoside can be used for the research of dental caries .
Assay Types