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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
29 Results for "
thymidine phosphorylase
" in MedChemExpress (MCE) Product Catalog:
Products (29)
29 Results for "thymidine phosphorylase" in MCE Product Catalog:
Target:
Research Areas:
Thymidine phosphorylase is a nucleoside metabolism enzyme that plays an important role in the pyrimidine salvage pathway. Thymidine phosphorylase catalyzes the conversion of thymidine to thymine and 2-deoxy-α-D-ribose-1-phosphate (dRib-1-P). Thymidine phosphorylase plays an important role in platelet activation in vitro and thrombosis in vivo by participating in multiple signaling pathways. Thymidine phosphorylase can be used for the study of myocardial infarction, stroke, pulmonary embolism and cancer .
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30 Publications Verification
Cat. No.: HY-B0016
CAS No.: 154361-50-9
Research Areas:
Capecitabine is an oral proagent that is converted to its active metabolite, 5-FU, by thymidine phosphorylase.
12
12 Cited Publications
Synonyms: 5-Iodo-2′-deoxyuridine; 5-IUdR; IdUrd
Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC50 value of 4.3 μM . Idoxuridine shows anti-orthopoxvirus activity.
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5 Cited Publications
Cat. No.: HY-A0063
CAS No.: 183204-72-0
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Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research.
5
5 Cited Publications
Cat. No.: HY-A0063A
CAS No.: 183204-74-2
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Tipiracil is a thymidine phosphorylase (TPase) inhibitor.
4
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Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a potent and orally active nucleoside antitumor agent. The composition of Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a 1:0.5 mixture (on a molar basis) of alpha,alpha,alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI). Trifluridine/tipiracil hydrochloride mixture (TAS-102) shows the antitumor activity mainly via the inhibition of thymidylate synthase (TS) and incorporation into DNA .
Cat. No.: HY-W009538
CAS No.: 66335-38-4
Synonyms: 5-Fluoro-5'-deoxycytidine
Research Areas:
5'-Deoxy-5-fluorocytidine (5-Fluoro-5'-deoxycytidine) is a cytidine analog and metabolite of Capecitabine (HY-B0016). 5'-Deoxy-5-fluorocytidine is converted from Capecitabine by carboxylesterase in the liver. 5'-Deoxy-5-fluorocytidine is deaminated by cytidine deaminase to generate 5'-deoxy-5-fluorouridine, which is finally converted into 5-fluorouracil (HY-90006) by thymidine phosphorylase in tumor tissues to exert anti-tumor effects. 5'-Deoxy-5-fluorocytidine is used in the researches for solid tumors such as colorectal cancer, non-small cell lung cancer and breast cancer .
Cat. No.: HY-B0016S
CAS No.: 1132662-08-8
Cat. No.: HY-B0016R
CAS No.: 154361-50-9
Research Areas:
Capecitabine (Standard) is the analytical standard of Capecitabine. This product is intended for research and analytical applications. Capecitabine is an oral proagent that is converted to its active metabolite, 5-FU, by thymidine phosphorylase.
Synonyms: 5'-O-Tritylinosine; 5'-O-Trityl-inosine
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KIN59 (5’-O-Tritylinosine) is a potent thymidine phosphorylase allosteric inhibitor. KIN59 inhibits FGF2-stimulated cell growth. KIN59 inhibits the expression of p-FGFR1, P-Akt in FGF2 (10 ng/mL) stimulated cells. KIN59 shows anti-tumor activity .
Cat. No.: HY-77537
CAS No.: 39929-79-8
Synonyms: 7DX
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7-Deazaxanthine (7DX) is an inhibitor of thymidine phosphorylase (TPase). 7-Deazaxanthine inhibits TPase reaction in a concentration-dependent manner with an IC50 value of 40 μM. 7-Deazaxanthine also has a significant angiogenesis inhibitory effect .
Cat. No.: HY-W009538R
CAS No.: 66335-38-4
Synonyms: 5-Fluoro-5'-deoxycytidine (Standard)
Research Areas:
5'-Deoxy-5-fluorocytidine (Standard) is the analytical standard of 5'-Deoxy-5-fluorocytidine (HY-W009538). This product is intended for research and analytical applications. 5'-Deoxy-5-fluorocytidine (5-Fluoro-5'-deoxycytidine) is a cytidine analog and metabolite of Capecitabine (HY-B0016). 5'-Deoxy-5-fluorocytidine is converted from Capecitabine by carboxylesterase in the liver. 5'-Deoxy-5-fluorocytidine is deaminated by cytidine deaminase to generate 5'-deoxy-5-fluorouridine, which is finally converted into 5-fluorouracil (HY-90006) by thymidine phosphorylase in tumor tissues to exert anti-tumor effects. 5'-Deoxy-5-fluorocytidine is used in the researches for solid tumors such as colorectal cancer, non-small cell lung cancer and breast cancer .
Synonyms: 5-Iodo-2′-deoxyuridine (Standard); 5-IUdR (Standard); IdUrd (Standard)
Idoxuridine (Standard) is the analytical standard of Idoxuridine. This product is intended for research and analytical applications. Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC50 value of 4.3 μM . Idoxuridine shows anti-orthopoxvirus activity.
Cat. No.: HY-181149
Urease/thymidine phosphorylase-IN-1 (compound 8) is a urease and thymidine phosphorylase inhibitor with a urease IC50 of 8.20 μM, thymidine phosphorylase IC50 of 9.29 μM. Urease/thymidine phosphorylase-IN-1 can be used for the research of helicobacter pylori infection, proteus mirabilis infection, cancer .
Cat. No.: HY-W012670
CAS No.: 18546-37-7
Cat. No.: HY-147969
CAS No.: 2422149-84-4
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Antiangiogenic agent 2 (compound 3b) is a potent thymidine phosphorylase inhibitor, with an IC50 of 39.71 μM. Antiangiogenic agent 2 shows anti-angiogenic activity .
Cat. No.: HY-B0307A
CAS No.: 17140-71-5
Synonyms: 5-Iodo-2′-deoxyuridine hydrate; 5-IUdR hydrate; IdUrd hydrate
Target:
Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) hydrate is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC50 value of 4.3 μM .
Target:
Pyrimidine nucleoside phosphorylase is an enzyme. The Pyrimidine nucleoside phosphorylase in Mycoplasma hyorhinis efficiently catalyzes the phosphorylation of thymidine and uridine, and exhibits (2 ,-deoxy)ribosyltransferase activity .
Cat. No.: HY-W008907
CAS No.: 7791-71-1
Synonyms: 5-OTT
Cat. No.: HY-A0063R
CAS No.: 183204-72-0
Research Areas:
Tipiracil (hydrochloride) (Standard) is the analytical standard of Tipiracil (hydrochloride). This product is intended for research and analytical applications. Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research.
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
