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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
130 Results for "
vascular permeability
" in MedChemExpress (MCE) Product Catalog:
Products (130)
130 Results for "vascular permeability" in MCE Product Catalog:
43
43 Publications Verification
Synonyms: PAF (C16)
Category:
Human Gut Microbiota Metabolites Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology
Target:
19
19
Research Areas:
19
19 Cited Publications
Cat. No.: HY-P7110A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: VEGFA; vascular Endothelial Growth Factor A; VEGF; VPF; vascular permeability Factor; vascular Endothelial Growth Factor A, Long Form; VEGF-A; L-VEGF; vascular Endothelial Growth Factor A121; vascular Endothelial Growth Factor A165; vascular Endothelial G
18
10
10 Cited Publications
Cat. No.: HY-N0570
CAS No.: 10597-60-1
Synonyms: DOPET; 3,4-Dihydroxyphenethyl alcohol; 3-Hydroxytyrosol
10
10 Cited Publications
Synonyms: AV-951; KRN951
Tivozanib (AV-951; KRN951) is a selective, orally active inhibitor for vascular endothelial growth factor receptor (VEGFR)-1, 2 3, with IC50s of 30, 6.5 and 15 nM, respectively. Tivozanib exhibits antitumor efficacy .
10
10 Cited Publications
Synonyms: AV-951 hydrochloride hydrate; KRN951 hydrochloride hydrate
Tivozanib hydrochloride hydrate is the hydrate hydrochloride form of Tivozanib (HY-10977). Tivozanib hydrochloride hydrate is a selective, orally active inhibitor for vascular endothelial growth factor receptor (VEGFR)-1, 2 3, with IC50s of 30, 6.5 and 15 nM, respectively. Tivozanib hydrochloride hydrate exhibits antitumor efficacy .
9
9 Cited Publications
Cat. No.: HY-D0799
CAS No.: 191671-46-2
Target:
Research Areas:
Sulfo-NHS-LC-Biotin sodium is an amine-reactive ester derivative of biotin and cannot pass the intact blood-retinal barrier. It can be used to assess vascular permeability of the brain and retinal vasculature.
9
9 Cited Publications
Cat. No.: HY-P7312
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: VEGFA; vascular Endothelial Growth Factor A; VEGF; VPF; vascular permeability Factor; vascular Endothelial Growth Factor A, Long Form; VEGF-A; L-VEGF; vascular Endothelial Growth Factor A121; vascular Endothelial Growth Factor A165; vascular Endothelial G
7
7 Cited Publications
Synonyms: AEGR-733 mesylate; BMS-201038 mesylate
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Lomitapide (AEGR-733; BMS-201038) mesylate is an orally active microsomal triglyceride transfer protein (MTP) inhibitor and a selective mTORC1 inhibitor with lipid-lowering activity and BBB permeability. Lomitapide mesylate significantly reduces plasma LDL levels by blocking the assembly and secretion of very-low-density lipoprotein (VLDL). Lomitapide mesylate inhibits mTORC1 in an ATP-dependent manner, thereby inducing AMPK-independent autophagic cell death and suppressing cancer cell growth and apoptosis. Lomitapide mesylate also enhances tumor infiltration of CD8 + T cells. In addition, Lomitapide mesylate inhibits HDAC, improves endothelial function, effectively alleviates vascular inflammation and oxidative stress, and exerts neuroprotective effects in a cerebral ischemia/reperfusion injury model. Lomitapide mesylate can be used in research on related diseases such as colorectal cancer, breast cancer, melanoma, ischemic stroke, and familial hypercholesterolemia .
7
Research Areas:
Famotidine (MK-208) is an orally active and highly selective histamine H2 receptor antagonist. It inhibits gastric acid secretion by blocking the Gs signaling pathway, and regulates intracellular cAMP and ERK pathways. Famotidine inhibits TLR3-mediated inflammatory pathways, and reduces the expression of various inflammatory mediators and interferon-related genes. Famotidine scavenges DPPH and nitric oxide free radicals, alleviates oxidative stress damage in gastric tissue, inhibits proMMP-9, improves vascular endothelial permeability, and restores the normal physiological functions of neutrophils and eosinophils. Famotidine crosses intestinal epithelial cells via facilitated diffusion and passive diffusion, blocks paracellular cation transport, and increases intestinal transepithelial electrical resistance. Famotidine reduces serum levels of transaminases and alkaline phosphatase, exerts analgesic effects and gastric protective effects simultaneously. Famotidine can be used in studies related to COVID-19, liver injury and acute gastric ulcer .
6
3
3 Cited Publications
Cat. No.: HY-P7311
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: VEGFA; vascular Endothelial Growth Factor A; VEGF; VPF; vascular permeability Factor; vascular Endothelial Growth Factor A, Long Form; VEGF-A; L-VEGF; vascular Endothelial Growth Factor A121; vascular Endothelial Growth Factor A165; vascular Endothelial G
2
2
2 Cited Publications
Cat. No.: HY-158082C
Synonyms: Tetramethyl rhodamine isothiocyanate glucan, MW 70000
2
2 Cited Publications
Cat. No.: HY-125864B
CAS No.: 9001-32-5
Research Areas:
Murine Fibrinogen is a native fibrinogen derived from mouse plasma. Murine Fibrinogen acts as a cerebrovascular permeability enhancer. Murine Fibrinogen activates matrix metalloproteinase-9 (MMP-9), downregulates the expression of vascular endothelial cadherin (VE-cadherin), and upregulates the expression of plasmalemmal vesicle-associated protein-1 (PV-1). Murine Fibrinogen increases macromolecular leakage from pial veins, thereby disrupting the microvascular integrity of cerebral blood vessels. Murine Fibrinogen can be used in studies related to cerebrovascular dysfunction .
2
2 Cited Publications
Cat. No.: HY-P7420
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: VEGFA; vascular Endothelial Growth Factor A; VEGF; VPF; vascular permeability Factor; vascular Endothelial Growth Factor A, Long Form; VEGF-A; L-VEGF; vascular Endothelial Growth Factor A121; vascular Endothelial Growth Factor A165; vascular Endothelial G
2
2 Cited Publications
Cat. No.: HY-P70458A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: VEGFA; vascular Endothelial Growth Factor A; VEGF; VPF; vascular permeability Factor; vascular Endothelial Growth Factor A, Long Form; VEGF-A; L-VEGF; vascular Endothelial Growth Factor A121; vascular Endothelial Growth Factor A165; vascular Endothelial G
1
1 Cited Publications
Synonyms: L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK
Target:
Research Areas:
Infection Neurological Disease Inflammation/Immunology Cancer
TPCK (L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK) is an effective serine protease inhibitor and also a blocker of the PDK1/Akt pathway. TPCK can modify the E7 protein in actively keratinocyte cells. TPCK can induce cellular apoptosis, suppress tumor growth, reduce hypoxic-ischemic brain injury in rat pups, and affect vascular permeability in inflamed rats .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
