121 Results for "

weight loss

" in MedChemExpress (MCE) Product Catalog:
Products (121)

121 Results for "weight loss" in MCE Product Catalog:

8
8 Publications Verification
Art. -Nr.: HY-19870C
CAS. Nr.: 2759937-80-7
Synonyms: RM-493 monoacetate; BIM-22493 monoacetate; IRC-022493 monoacetate
Setmelanotide monoacetate (RM-493 monoacetate) is a blood-brain barrier-permeable, selective MC4R agonist with a Ki value of 2.1 nM for hMC4R. Setmelanotide monoacetate activates the CaMKK2/AMPK signaling pathway. Setmelanotide monoacetate mediates body weight homeostasis, feeding regulation and energy expenditure modulation; it reduces food intake, induces weight loss, decreases obesity severity, increases daytime activity and energy expenditure, lowers levels of leptin, triglycerides, fasting insulin and diastolic blood pressure, improves insulin sensitivity, glucose tolerance and fatty liver condition, and reverses respiratory depression. Setmelanotide monoacetate is applicable to research related to obesity, hyperinsulinemia, fatty liver and respiratory depression .
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3 Cited Publications
Art. -Nr.: HY-P3462
CAS. Nr.: 1415456-99-3
Target:  

CGRP Receptor

Forschungsgebiete:  

Metabolic Disease

Cagrilintide is an investigational novel long-acting acylated amylin analogue, acts as nonselective amylin receptors (AMYR) and calcitonin G protein-coupled receptor (CTR) agonist. Cagrilintide induces significant weight loss and reduces food intake. Cagrilintide has the potential for the research of obesity .
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3 Cited Publications
Art. -Nr.: HY-P3462A
Target:  

CGRP Receptor

Forschungsgebiete:  

Metabolic Disease

Cagrilintide acetate is a non-selective AMYR/CTR agonist and long-acting acylated amylase analogue. Cagrilintide acetate causes a reduction in food intake and significant weight loss in a dose-dependent manner. Cagrilintide acetate can be used in obesity studies .
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3 Cited Publications
Art. -Nr.: HY-B0723
CAS. Nr.: 128607-22-7
Synonyms: FC-1271a
Ospemifene (FC-1271a) is an orally active and non-estrogenic selective estrogen receptor modulator (SERM) with Ki values of 380 and 410 nM for estrogen receptor α (ERα) and ERβ, respectively. Ospemifene inhibits caspase-3 activity. Ospemifene inhibits neuronal degeneration, prevents bone loss, and increases vaginal weight and vaginal epithelial height. Ospemifene has anticancer activity against breast cancer .
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3 Cited Publications
Art. -Nr.: HY-B0337
CAS. Nr.: 122-11-2
Synonyms: Sulphadimethoxine
Target:  

Bacterial Antibiotic

Forschungsgebiete:  

Infection

Sulfadimethoxine (Sulphadimethoxine) is an orally active sulfonamide antibiotic. Sulfadimethoxine reduces Eimeria-related mortality, weight loss, and lesions. Sulfadimethoxine can be used for the research of avian coccidiosis .
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3 Cited Publications
Art. -Nr.: HY-N0132
CAS. Nr.: 94-07-5
Synonyms: Oxedrine
Synephrine (Oxedrine), an alkaloid, is an α-adrenergic and β-adrenergic agonist derived from the Citrus aurantium. Synephrine is a sympathomimetic compound and can be used for weight loss .
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3 Cited Publications
Art. -Nr.: HY-B0337A
CAS. Nr.: 1037-50-9
Synonyms: Sulphadimethoxine sodium
Target:  

Bacterial Antibiotic

Forschungsgebiete:  

Infection

Sulfadimethoxine (Sulphadimethoxine) sodium is an orally active sulfonamide antibiotic. Sulfadimethoxine sodium reduces Eimeria-related mortality, weight loss, and lesions. Sulfadimethoxine sodium can be used for the research of avian coccidiosis .
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3 Cited Publications
Art. -Nr.: HY-N0132A
CAS. Nr.: 5985-28-4
Synonyms: Oxedrine hydrochloride
Synephrine (Oxedrine) hydrochloride, an alkaloid, is an α-adrenergic and β-adrenergic agonist derived from the Citrus aurantium. Synephrine hydrochloride is a sympathomimetic compound and can be used for weight loss .
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2 Cited Publications
Art. -Nr.: HY-N10424
CAS. Nr.: 600-76-0
Brazilein is a compound with anti-inflammatory and neuroprotective activities, with an IC50 of 500 μM against guinea pig Na +,K +-ATPase. Brazilein reduces iNOS mRNA expression, thereby inhibiting nitric oxide production in immune cells. Brazilein suppresses inflammatory responses by reducing the mRNA expression of TNF-α and IL-6, but has no effect on IL-1β expression. Brazilein reduces the cerebral infarction volume and improves the neurological function scores of rats with cerebral ischemia-reperfusion injury. Brazilein induces apoptosis of splenic lymphocytes in mice. Brazilein inhibits humoral immune responses in mice, and causes thymus and spleen atrophy as well as body weight loss in mice. Brazilein also possesses antimalarial and antibacterial activities. Brazilein is also a red dye. Brazilein can be used in studies related to the infection, nervous system, cardiovascular system and inflammatory diseases .
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1 Cited Publications
Art. -Nr.: HY-N1437
CAS. Nr.: 6205-14-7
Hydroxycitric acid is an orally active, multi-target, multi-bioactive organic acid. activates Nrf2 and its downstream molecule GPX4, increases glutathione levels, and thereby inhibits ferroptosis. Hydroxycitric acid activates the Nrf2/Keap1 and ACLY/NF-κB signaling pathways, upregulates the activities of antioxidant enzymes such as superoxide dismutase, reduces MDA content, thereby alleviating oxidative stress and renal tubular epithelial cell apoptosis, and improves pulmonary vascular and right ventricular remodeling. Hydroxycitric acid activates both the AMPK and mTORC1/S6K pathways, triggers the unfolded protein response, arrests the cancer cell cycle, and induces DNA fragmentation .
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1 Cited Publications
Art. -Nr.: HY-P3463
CAS. Nr.: 123475-27-4
Synonyms: GLP-1 (human)
Target:  

GCGR

Beinaglutide is a human GLP-1 polypeptide that shares almost 100% homology with human GLP-1 (7–36). Beinaglutide displays does-dependent effects in glycemic control, inhibiting food intake and gastric empty and promoting weight loss. Beinaglutide has the potential for the research of overweight/obesity and nonalcoholic steatohepatitis (NASH) .
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1 Cited Publications
Art. -Nr.: HY-P2231
CAS. Nr.: 1686108-82-6
Synonyms: MEDI0382
Target:  

GCGR

Forschungsgebiete:  

Metabolic Disease

Cotadutide (MEDI0382) is a potent dual agonist of glucagon-like peptide-1 (GLP-1) and GCGR with EC50 values of 6.9 pM and 10.2 pM, respectively. Cotadutide exhibits ability to facilitate both weight loss and glycaemic control, and alleviate fibrosis. Cotadutide can be used in the research of obesity and type 2 diabetes (T2D) .
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1 Cited Publications
Art. -Nr.: HY-P2231A
Synonyms: MEDI0382 acetate
Target:  

GCGR

Forschungsgebiete:  

Metabolic Disease

Cotadutide (MEDI0382) acetate is a potent dual agonist of glucagon-like peptide-1 (GLP-1) and GCGR with EC50 values of 6.9 pM and 10.2 pM, respectively. Cotadutide acetate exhibits ability to facilitate both weight loss and glycaemic control, and alleviate fibrosis. Cotadutide acetate can be used in the research of obesity and type 2 diabetes (T2D) .
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1 Cited Publications
Art. -Nr.: HY-119024
CAS. Nr.: 112170-24-8
Reinheit:  98.88%
Target:  

SHP1 STAT

Forschungsgebiete:  

Cancer

BCI-137 is a Argonaute 2 (AGO2) inhibitor. By inhibiting AGO2 function, reducing PTPN6/SHP-1 protein levels and enhancing STAT1 phosphorylation, BCI-137 restores the sensitivity of tumor cells to IFN-γ. BCI-137 effectively enhances the recruitment, activation and cytotoxicity of CD8 + T cells. BCI-137 exerts a synergistic effect with anti-PD-1 antibodies and significantly reduces tumor volume in preclinical mouse models. BCI-137 exhibits favorable safety profiles and does not cause significant weight loss or death in mice. BCI-137 can be used in research related to bladder cancer, colorectal cancer, melanoma and other related fields .
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1 Cited Publications
Art. -Nr.: HY-P0267
CAS. Nr.: 121062-08-6
Melanotan (MT)-II is a melanocortin receptor agonist. Melanotan (MT)-II activates melanocortin receptor 3 and melanocortin receptor 4, and stimulates the release of central endogenous oxytocin. Melanotan (MT)-II reverses recognition memory impairment, increased anxiety levels and reduced exploratory tendency in zebrafish exposed to short-term high-fat diet. Melanotan (MT)-II improves impaired social behavior indicators in mouse models of autism spectrum disorder. Melanotan (MT)-II induces weight loss, reduces food intake and exerts anorectic effects. Melanotan (MT)-II increases intracavernous pressure and erectile activity in brown rats. Melanotan (MT)-II can be used in studies related to memory impairment, anxiety, reduced exploratory behavior, autism spectrum disorder, obesity and erectile dysfunction .
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Art. -Nr.: HY-P10798
CAS. Nr.: 2883634-40-8
Synonyms: LY-3841136
Forschungsgebiete:  

Metabolic Disease

Eloralintide (LY-3841136) is an amylin receptor agonist with human AMY1R EC50 23.9 pM and human AMY3R EC50 253.8 pM. Eloralintide induces decreased appetite, reduced food intake, body weight and fat mass loss, prolonged plasma calcium 2+ reduction, and weak conditioned taste avoidance. Eloralintide can be used for the research of obesity .
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Art. -Nr.: HY-126360
CAS. Nr.: 15646-46-5
Reinheit:  ≥98.0%
Forschungsgebiete:  

Inflammation/Immunology

Oxazolone is a haptenizing agent that induces acute or chronic inflammation of the large intestine and is used to construct models of colitis. Oxazolone can cause Th1/Th2-dependent colitis with weight loss and diarrhea. Oxazolone-induced inflammation can be mitigated by neutralizing anti-IL-4 or anti-TNF-α antibodies or decoy IL-13R2-α-FC proteins .
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Art. -Nr.: HY-P10745
CAS. Nr.: 2766385-23-1
Synonyms: ZP8396
Target:  

Amylin Receptor

Forschungsgebiete:  

Metabolic Disease

Petrelintide (ZP8396) is a dual amylin and calcitonin receptor agonist (DACRA) Petrelintide elicits a selective reduction in high-fat diet intake in diet-induced obese (DIO) rats, which is accompanied by a loss of fat mass and preservation of lean mass during weight reduction. Petrelintide can be utilized in diabetes research .
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Art. -Nr.: HY-P10745A
Synonyms: ZP8396 acetate
Target:  

Amylin Receptor

Forschungsgebiete:  

Metabolic Disease

Perelintide (ZP8396) acetate is a dual amylin and calcitonin receptor agonist (DACRA). Perelintide acetate elicits a selective reduction in high-fat diet intake in diet-induced obese (DIO) rats, which is accompanied by a loss of fat mass and preservation of lean mass during weight reduction. Perelintide acetate can be utilized in diabetes research .
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Art. -Nr.: HY-P10736
Target:  

GCGR

Forschungsgebiete:  

Metabolic Disease

AMG133 peptide payload is a GLP-1 analog agonist peptide. AMG133 peptide potently activates GLP-1R, and exhibits weight loss and metabolic improvement activities. AMG133 peptide payload can be used for the synthesis of AMG 133 (HY-164535) .
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