600-76-0
Chemical Structure
Brazilein
- CAS. Nr.: 600-76-0
- Formula:C16H12O5
- Molecular Weight:284.26
IUPAC Name: (R)-2-(((1-(3-(2-cyanobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperidin-3-yl)amino)methyl)benzonitrile
InChIKey: MLWIYODOURBGPI-UHFFFAOYSA-N
SMILES: O=C1C=C2C(C=C1O)=C3C4=C(OCC3(C2)O)C=C(O)C=C4
Biological Activity: Brazilein is a compound with anti-inflammatory and neuroprotective activities, with an IC50 of 500 μM against guinea pig Na+,K+-ATPase. Brazilein reduces iNOS mRNA expression, thereby inhibiting nitric oxide production in immune cells. Brazilein suppresses inflammatory responses by reducing the mRNA expression of TNF-α and IL-6, but has no effect on IL-1β expression. Brazilein reduces the cerebral infarction volume and improves the neurological function scores of rats with cerebral ischemia-reperfusion injury. Brazilein induces apoptosis of splenic lymphocytes in mice. Brazilein inhibits humoral immune responses in mice, and causes thymus and spleen atrophy as well as body weight loss in mice. Brazilein also possesses antimalarial and antibacterial activities. Brazilein is also a red dye. Brazilein can be used in studies related to the infection, nervous system, cardiovascular system and inflammatory diseases[1][2][3].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Brazilein | 99.9% | Brazilein is a compound with anti-inflammatory and neuroprotective activities, with an IC50 of 500 μM against guinea pig Na+,K+-ATPase. Brazilein reduces iNOS mRNA expression, thereby inhibiting nitric oxide production in immune cells. Brazilein suppresses inflammatory responses by reducing the mRNA expression of TNF-α and IL-6, but has no effect on IL-1β expression. Brazilein reduces the cerebral infarction volume and improves the neurological function scores of rats with cerebral ischemia-reperfusion injury. Brazilein induces apoptosis of splenic lymphocytes in mice. Brazilein inhibits humoral immune responses in mice, and causes thymus and spleen atrophy as well as body weight loss in mice. Brazilein also possesses antimalarial and antibacterial activities. Brazilein is also a red dye. Brazilein can be used in studies related to the infection, nervous system, cardiovascular system and inflammatory diseases. | ||||||||||||||||||||
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Kigelinone | Kigelinone is a natural product. | |||||||||||||||||||||
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Hematein | 59.09% | Hematein is a oxidation product of hematoxylin acted as a dye. Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells. | ||||||||||||||||||||
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Miaosporone A | Miaosporone A, an angucyclic quinone, exhibits antimalarial activity against Plasmodium falciparum K1 and antibacterial activity against Mycobacterium tuberculosis with respective IC50 values of 2.5 and 2.4 μM and displays cytotoxic activities against both cancerous (MCF-7 and NCI-H187) and nonmalignant (Vero) cells. | |||||||||||||||||||||
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Haginin D | Haginin D is an isoflavonoid phenolic compound found in the stems of Lespedeza homoloba. Haginin D suppresses lipid peroxidation in rat brain homogenates. Haginin D scavenges superoxide anion free radicals. Haginin D can be used in studies of oxidative damage and allergic reactions. | |||||||||||||||||||||
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Ochracenomicin A | Ochracenomicin A has a strong effect against Gram-positive bacteria (including MRSA strain), and also against Gram-negative bacteria and candida albicans. | |||||||||||||||||||||
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Sakyomicin B | Sakyomicin B is a Benzoquinone antibiotic found in the strain of Nocardia sp. M-53. Sakyomicin B has activity against Gram-positive bacteria and mycobacteria. | |||||||||||||||||||||
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Glyceollin II | Glyceollin II is a glyceollin found in soybean cotyledons (CY. Harosoy 63) inoculated with Phytophthora megaspenna f.sp. glycinea race 1. Glyceollin II inhibits the radial mycelial growth of P. megasperma f.sp. gbcinea race 1. Glyceollin II inhbiits zoospore germination (ED50 = 7 μg/mL) and causes zoospores to burst. Glyceollin II can be used for the research of Phytophthora megasperma f.sp. glycinea infection in soybeans. | |||||||||||||||||||||
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Pendulone | 98.86% | Pendulone is a isoflavanquinone with good antiplasmodial activity with an IC50 of 7.0 μM. Pendulone also has antileishmanial, antibacterial and anticancer activity. | ||||||||||||||||||||
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Loureiriol | Loureiriol is a homoisoflavonoid with weak anticancer effects. | |||||||||||||||||||||
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Juncuenin D | Juncuenin D induces caspase-3-mediated cytotoxicity in HT22 cells. Juncuenin D also has anti-bacterial activity against MRSA strains. Juncuenin D can be isolated from J. effusus. | |||||||||||||||||||||
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References
- [1]. Shen J, et al. Brazilein protects the brain against focal cerebral ischemia reperfusion injury correlating to inflammatory response suppression. Eur J Pharmacol. 2007;558(1-3):88-95. [Content Brief]
- [2]. Zhao YN, et al. Study on cardioactive effects of brazilein. Pharmacology. 2006;76(2):76-83. [Content Brief]
- [3]. Ye M, et al. Brazilein, an important immunosuppressive component from Caesalpinia sappan L. Int Immunopharmacol. 2006;6(3):426-432. [Content Brief]
