2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. seco-CBI-PBD-disulfide linker

seco-CBI-PBD-disulfide linker is a conjugate of an ADC drug toxin molecule and a linker, consisting of two potent DNA-damaging moieties seco-CBI, PBD (HY-101127), and a disulfide linker.

For research use only. We do not sell to patients.

seco-CBI-PBD-disulfide linker

seco-CBI-PBD-disulfide linker Chemical Structure

CAS No. : 1884642-01-6

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seco-CBI-PBD-disulfide linker Related Antibodies

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Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

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Description

seco-CBI-PBD-disulfide linker is a conjugate of an ADC drug toxin molecule and a linker, consisting of two potent DNA-damaging moieties seco-CBI, PBD (HY-101127), and a disulfide linker[1].

Molecular Weight

946.38

Formula

C41H45ClN5O13PS2
CAS No.
SMILES

O=C(N(C1=CC(OCCCCCC(N(C2)C(C=C(C3=CC=CC=C34)OP(O)(O)=O)=C4[C@@H]2CCl)=O)=C(OC)C=C51)C(O)[C@@]6(CCCN6C5=O)[H])OCC(C)SSC7=NC=C([N+]([O-])=O)C=C7
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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seco-CBI-PBD-disulfide linker Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

seco-CBI-PBD-disulfide linker1884642-01-6ADC LinkerAntibody-drug conjugates linkerDNA strand breakspreclinical tumor xenograft modelsDNA minor grooveA-T-rich regionsadenine residuescancer cellantibody-drug conjugatesDNAHER2trastuzumab emtansineInhibitorinhibitorinhibit

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seco-CBI-PBD-disulfide linker
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