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Cat. No.: HY-185495

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seco-CBI-PBD-disulfide linker

seco-CBI-PBD-disulfide linker is a conjugate of an ADC drug toxin molecule and a linker, consisting of two potent DNA-damaging moieties seco-CBI, PBD (HY-101127), and a disulfide linker.

For research use only. We do not sell to patients.

CAS No.: 1884642-01-6
Formula: C₄₁H₄₅ClN₅O₁₃PS₂
Molecular Weight:946.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

seco-CBI-PBD-disulfide linker Chemical Structure

CAS No.: 1884642-01-6

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Biological Activity

Description

seco-CBI-PBD-disulfide linker is a conjugate of an ADC drug toxin molecule and a linker, consisting of two potent DNA-damaging moieties seco-CBI, PBD (HY-101127), and a disulfide linker^[1].

All ADC Linkers Isoforms :

Chemical Information

CAS No. 1884642-01-6
Molecular Weight 946.38
Formula C₄₁H₄₅ClN₅O₁₃PS₂
SMILES

O=C(N(C1=CC(OCCCCCC(N(C2)C(C=C(C3=CC=CC=C34)OP(O)(O)=O)=C4[C@@H]2CCl)=O)=C(OC)C=C51)C(O)[C@@]6(CCCN6C5=O)[H])OCC(C)SSC7=NC=C([N+]([O-])=O)C=C7
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yao HP, et al. Duocarmycin-based antibody-drug conjugates as an emerging biotherapeutic entity for targeted cancer therapy: Pharmaceutical strategy and clinical progress. Drug Discov Today. 2021;26(8):1857-1874. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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seco-CBI-PBD-disulfide linker

All ADC Linkers Isoforms