Seletracetam lithium
Based on 1 publication(s) in Google Scholar
Seletracetam (Ucb 44212) lithium, as an analog of the antiepileptic agent Levetiracetam, is a SV2A modulator for the research of epilepsy.
For research use only. We do not sell to patients.
- Formula: C10H14F2LiN2O2
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Seletracetam lithium
More
Biological Activity
SV2A[1]
Seletracetam lithium decreases seizure activity in a number of epilepsy models and binds to the synaptic vesicle protein SV2A[2].
Seletracetam lithium decreases synaptic responses in a time-, frequency- and concentration-dependent manner[2].
Seletracetam lithium modifies rates of presynaptic release[2].
Seletracetam lithium inhibits high-voltage-activated Ca2+ currents and intracellular Ca2+ increase in rat cortical neurons in vitro[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
The product can be reconstituted/diluted with sterile PBS or saline.
Chemical Information
-
Formula C10H14F2LiN2O2
-
SMILES
O=C([C@@H](N1C(C[C@H](C1)/C=C(F)\F)=O)CC)N.[Li]
-
Synonyms
Ucb 44212 lithium
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Ann Neurol
Intranasal Seletracetam in a Patient with Reading Epilepsy: First-in-Human Use to Prevent Reflex Seizures. [Abstract]2025 Dec 29. PMID: 41459805
Purity & Documentation
References
[1]. Pollard JR, et al. Seletracetam, a small molecule SV2A modulator for the treatment of epilepsy. Curr Opin Investig Drugs. 2008 Jan;9(1):101-7. [Content Brief]
[2]. Martella G, et al. Seletracetam (ucb 44212) inhibits high-voltage-activated Ca2+ currents and intracellular Ca2+ increase in rat cortical neurons in vitro. Epilepsia. 2009 Apr;50(4):702-10. [Content Brief]
[3]. Yang X, et al. Seletracetam enhances short term depression in vitro. Epilepsy Res. 2015 Nov;117:17-22. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Seletracetam lithium Related Classifications
HY-119810A Related Classifications
Powered by Bioz