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Seletracetam lithium bromide (Synonyms: Ucb 44212 lithium bromide)

Cat. No.: HY-119810B
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Seletracetam (Ucb 44212) lithium bromide, an analog of the antiepileptic agent Levetiracetam, is a SV2A modulator for the research of epilepsy.

For research use only. We do not sell to patients.

Seletracetam lithium bromide Chemical Structure

Seletracetam lithium bromide Chemical Structure

CAS No. : 2024584-38-9

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Description

Seletracetam (Ucb 44212) lithium bromide, an analog of the antiepileptic agent Levetiracetam, is a SV2A modulator for the research of epilepsy[1][2][3].

IC50 & Target

IC50: SV2A[1]

In Vitro

Seletracetam displays one-log-unit higher affinity (pKi=7.1) than Levetiracetam (6.1) to the LEV-binding site[2].
Seletracetam lithium bromide inhibits high-voltage-activated Ca2+ currents and intracellular Ca2+ increase in rat cortical neurons in vitro[2].
Seletracetam (1-10 μM) lithium bromide reduces both the amplitude and repetitive firing of population spikes induced by a high K+/low Ca2+ concentration fluid (HKLCF) in rat hippocampal slices[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Seletracetam (intraperitoneal injection) lithium bromide displays potent protection against secondary generalised motor seizures in fully corneally-kindled mice (ED50 0.31 mg/kg). In audiogenic seizure susceptible mice, Seletracetam (i.p) protects against clonic convulsion expression with an ED50 of 0.17 mg/kg[3].
Seletracetam (0.0074 mg/kg to 74 mg/kg; intraperitoneal injection) lithium bromide increases the generalized seizure threshold current and decreases the duration of the after-discharge and the seizure severity observed at the after-discharge threshold current, and generally has a much more potent effect than previously observed for Levetiracetam[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Wistar rats (200-220 g) (Amygdala-kindled rats)[3]
Dosage: 0.0074,7.4, 74 mg/kg
Administration: Intraperitoneal injection; 60 min before seizure threshold determination
Result: Markedly increased the generalized seizure threshold at all doses tested, with increases of 190% (0.0074 mg/kg), 302% (0.074 mg/kg), 429% (0.74 mg/kg), 433% (7.4 mg/kg) and 679% (74 mg/kg).
Clinical Trial
Molecular Weight

275.74

Formula

C₁₀H₁₄F₂N₂O₂.₁/₂BrLi

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Seletracetam lithium bromide
Cat. No.:
HY-119810B
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