Seletracetam lithium bromide
Based on 1 publication(s) in Google Scholar
Seletracetam (Ucb 44212) lithium bromide, an analog of the antiepileptic agent Levetiracetam, is a SV2A modulator for the research of epilepsy.
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- CAS No.: 2024584-38-9
- 화학식: C10H14F2N2O2.1/2BrLi
- 분자량:275.74
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Seletracetam lithium bromide
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Biological Activity
IC50: SV2A[1]
Seletracetam displays one-log-unit higher affinity (pKi=7.1) than Levetiracetam (6.1) to the LEV-binding site[2].
Seletracetam lithium bromide inhibits high-voltage-activated Ca2+ currents and intracellular Ca2+ increase in rat cortical neurons in vitro[2].
Seletracetam (1-10 μM) lithium bromide reduces both the amplitude and repetitive firing of population spikes induced by a high K+/low Ca2+ concentration fluid (HKLCF) in rat hippocampal slices[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Seletracetam (0.0074 mg/kg to 74 mg/kg; intraperitoneal injection) lithium bromide increases the generalized seizure threshold current and decreases the duration of the after-discharge and the seizure severity observed at the after-discharge threshold current, and generally has a much more potent effect than previously observed for Levetiracetam[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female Wistar rats (200-220 g) (Amygdala-kindled rats)[3]
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Dosage:0.0074,7.4, 74 mg/kg
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Administration:Intraperitoneal injection; 60 min before seizure threshold determination
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Result:Markedly increased the generalized seizure threshold at all doses tested, with increases of 190% (0.0074 mg/kg), 302% (0.074 mg/kg), 429% (0.74 mg/kg), 433% (7.4 mg/kg) and 679% (74 mg/kg).
Chemical Information
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CAS No. 2024584-38-9
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분자량 275.74
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화학식 C10H14F2N2O2.1/2BrLi
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SMILES
Br[Li].NC([C@@H](N1C(C[C@H](C1)/C=C(F)\F)=O)CC)=O.[1/2]
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Synonyms
Ucb 44212 lithium bromide
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Ann Neurol
Intranasal Seletracetam in a Patient with Reading Epilepsy: First-in-Human Use to Prevent Reflex Seizures. [Abstract]2025 Dec 29. PMID: 41459805
순도&문서
References
[1]. Pollard JR, et al. Seletracetam, a small molecule SV2A modulator for the treatment of epilepsy. Curr Opin Investig Drugs. 2008 Jan;9(1):101-7. [Content Brief]
[2]. Martella G, et al. Seletracetam (ucb 44212) inhibits high-voltage-activated Ca2+ currents and intracellular Ca2+ increase in rat cortical neurons in vitro. Epilepsia. 2009 Apr;50(4):702-10. [Content Brief]
[3]. Matagne A, et al. Profile of the new pyrrolidone derivative seletracetam (ucb 44212) in animal models of epilepsy. Eur J Pharmacol. 2009;614(1-3):30-37. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Seletracetam lithium bromide Related Classifications
HY-119810B Related Classifications
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