Sodium 3-methyl-2-oxobutanoate-13C5
Based on 1 Customer Validation
Sodium 3-methyl-2-oxobutanoate-13C5 is the 13C labeled Sodium 3-methyl-2-oxobutanoate. Sodium 3-methyl-2-oxobutanoate is a precursor of pantothenic acid in Escherichia coli.
For research use only. We do not sell to patients.
- Purity: 99.0%
- CAS No.: 1173018-24-0
- Formula: 13C5H7NaO3
- Molecular Weight:143.06
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1173018-24-0
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Unlabeled CAS 3715-29-5
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Appearance Solid
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Molecular Weight 143.06
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Formula 13C5H7NaO3
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Color White to off-white
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SMILES
[13CH3][13CH]([13CH3])[13C]([13C](O[Na])=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
H2O : ≥ 100 mg/mL (699.01 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. MAAS WK, et al. alpha-Ketoisovaleric acid, a precursor of pantothenic acid in Escherichia coli. J Bacteriol. 1953 Apr;65(4):388-93. [Content Brief]
[3]. Schauder P, et al. Oral administration of alpha-ketoisovaleric acid or valine in humans: blood kinetics and biochemical effects. J Lab Clin Med. 1984 Apr103(4):597-605. [Content Brief]
[4]. Coitinho AS, et al. Pharmacological evidence that alpha-ketoisovaleric acid induces convulsions through GABAergic and glutamatergic mechanisms in rats. Brain Res. 2001 Mar 9894(1):68-73. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 6.9901 mL | 34.9504 mL | 69.9007 mL | 174.7519 mL |
| 5 mM | 1.3980 mL | 6.9901 mL | 13.9801 mL | 34.9504 mL | |
| 10 mM | 0.6990 mL | 3.4950 mL | 6.9901 mL | 17.4752 mL | |
| 15 mM | 0.4660 mL | 2.3300 mL | 4.6600 mL | 11.6501 mL | |
| 20 mM | 0.3495 mL | 1.7475 mL | 3.4950 mL | 8.7376 mL | |
| 25 mM | 0.2796 mL | 1.3980 mL | 2.7960 mL | 6.9901 mL | |
| 30 mM | 0.2330 mL | 1.1650 mL | 2.3300 mL | 5.8251 mL | |
| 40 mM | 0.1748 mL | 0.8738 mL | 1.7475 mL | 4.3688 mL | |
| 50 mM | 0.1398 mL | 0.6990 mL | 1.3980 mL | 3.4950 mL | |
| 60 mM | 0.1165 mL | 0.5825 mL | 1.1650 mL | 2.9125 mL | |
| 80 mM | 0.0874 mL | 0.4369 mL | 0.8738 mL | 2.1844 mL | |
| 100 mM | 0.0699 mL | 0.3495 mL | 0.6990 mL | 1.7475 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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