Sodium trimetaphosphate

Sodium Trimetaphosphate (Trisodium cyclo-triphosphate) (150 min) does not undergo significant hydrolysis in heparinized rabbit blood incubated at 38°C, but induces increased orthophosphate leakage from blood cells compared to controls^[2].
Sodium trimetaphosphate undergoes alkaline hydrolysis to sodium tripolyphosphate in aqueous solutions via a rate-controlled consecutive mechanism, with reaction rate constants ranging from 0.0046 to 0.525 (Mole/L)^-1(Min)^-1, and rates increasing with solids concentration, NaOH ratio, temperature, and sodium sulfate addition^[3].
Sodium trimetaphosphate converts to sodium tripolyphosphate via drum drying of sodium trimetaphosphate-NaOH solutions, without forming sodium acid tripolyphosphate, with tripolyphosphate degradation increasing with excess NaOH^[3].
Sodium trimetaphosphate converts to sodium tripolyphosphate in concentrated Na⁺OH⁻ solutions, with tripolyphosphate stability decreasing with higher Na⁺OH⁻ concentration and temperature; at 50.0°C or 70.0°C with 20% Na⁺OH⁻, tripolyphosphate remains stable, while at 35% or 50% Na⁺OH⁻, tripolyphosphate degrades to pyrophosphate and orthophosphate^[3].
Sodium trimetaphosphate converts to sodium tripolyphosphate via sodium carbonate in 20% solids solutions at 70°C, with a 50% conversion time of 200 minutes, which is far slower than the 2-minute 50% conversion time with stoichiometric sodium hydroxide^[3].
Sodium trimetaphosphate converts to sodium tripolyphosphate in detergent slurries with <60% solids at a rate controlled by the chemical reaction, reaching 97% conversion in 5 minutes at 100°C^[3].
Sodium trimetaphosphate reacts with methyl α-D-glucopyranoside in alkaline medium (pH 10-13.5) to form crosslinked monophosphate (P_c) and grafted monophosphate (P_g) in a ~2:1 ratio via a two-step mechanism involving grafted tripolyphosphate (STPP₉) as an intermediate, with reaction stopping at pH <10 and degradation dominating at pH >13.9^[4].
Sodium trimetaphosphate (0.1 M) crosslinks pullulan in alkaline medium to form hydrogels containing the same phosphorylated species (P_g, P_c, STPP₉) observed in the methyl α-D-glucopyranoside model system, confirming the model's validity for polysaccharide crosslinking^[4].
Sodium trimetaphosphate is highly stable at pH 5.4 but undergoes immediate, temperature-dependent alkaline hydrolysis to tripolyphosphate at pH 13.5, with degradation inhibited at pH ≤11^[4].
Sodium Trimetaphosphate increases the heat sensitivity of Salmonella typhimurium in peptone diluent or complex laboratory media^[2].
Sodium trimetaphosphate does not inhibit planktonic Candida albicans or Streptococcus mutans at the concentrations tested in the MIC assay^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.