2. Protein Tyrosine Kinase/RTK
  3. c-Fms
  4. Sotuletinib dihydrochloride

Sotuletinib dihydrochloride  (Synonyms: BLZ945 dihydrochloride)

Cat. No.: HY-12768B
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Sotuletinib (BLZ945) dihydrochloride is an orally active and blood-brain barrier-permeable CSF1-R-specific inhibitor (IC50=1 nM). Sotuletinib (BLZ945) dihydrochloride induces tumor cell apoptosis and effectively inhibits tumor growth in mouse models. Sotuletinib dihydrochloride can be used in cancer and amyotrophic lateral sclerosis (ALS) research.

For research use only. We do not sell to patients.

Sotuletinib dihydrochloride Chemical Structure

Sotuletinib dihydrochloride Chemical Structure

CAS No. : 2222138-40-9

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Sotuletinib dihydrochloride Related Antibodies

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Description

Sotuletinib (BLZ945) dihydrochloride is an orally active and blood-brain barrier-permeable CSF1-R-specific inhibitor (IC50=1 nM). Sotuletinib (BLZ945) dihydrochloride induces tumor cell apoptosis and effectively inhibits tumor growth in mouse models. Sotuletinib dihydrochloride can be used in cancer and amyotrophic lateral sclerosis (ALS) research[1].

IC50 & Target

IC50: CSF1-R (1 nM)[1].
Clinical Trial
Molecular Weight

471.40

Formula

C20H24Cl2N4O3S
CAS No.
SMILES

O=C(C1=NC=CC(OC2=CC=C3N=C(N[C@H]4[C@H](O)CCCC4)SC3=C2)=C1)NC.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Sotuletinib dihydrochloride Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sotuletinib2222138-40-9BLZ945BLZ 945BLZ-945c-FmsCSF-1 receptorcolony stimulating factor 1 receptorCSF-1RCSF1RALScancertumorglioma cellsU251Inhibitorinhibitorinhibit

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