country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-106987

Copy Link Print Information

SP/W 5186

SP/W-5186 is a nitric oxide (NO) donor agent containing a cysteine structure. SP/W-5186 can improve cardiac function, reduce myocardial damage, protect vascular endothelial function and inhibit inflammation and oxidative stress. SP/W-5186 has the ability to inhibit oxidative damage induced by peroxynitrite (ONOO⁻). SP/W-5186 can be used in the research of myocardial ischemia-reperfusion injury.

For research use only. We do not sell to patients.

CAS No.: 139146-65-9
Formula: C₁₄H₂₃N₃O₈S
Molecular Weight:393.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (244 KB)

SP/W 5186 Chemical Structure

CAS No.: 139146-65-9

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All NO Synthase Isoforms :

In Vivo

SP/W-5186 (0.3-1 μmol/kg, i.v., single dose) releases NO and significantly protects myocardial tissue from reperfusion injury in rabbits^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Myocardial ischemia-reperfusion injury model established in adult male New Zealand white rabbits (2.8-3.5 kg)^[1]
Dosage:

0.3 and 1 μmol/kg
Administration:

Intravenous injection (i.v.), single dose
Result:

Significantly improved the recovery of cardiac function.
Effectively alleviated myocardial cell damage.
Effectively inhibited the aggregation and infiltration of neutrophils in the myocardium, as well as the MDA content and platelet aggregation in the myocardial tissue.
Significantly improved the vasodilatory response of blood vessels to ACh, indicating that it effectively protected the endothelial function.

Chemical Information

CAS No. 139146-65-9
Molecular Weight 393.41
Formula C₁₄H₂₃N₃O₈S
SMILES

CC(CO[N+]([O-])=O)(C)C(N[C@H](C(OCC)=O)CSC(CNC(C)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.