2. GPCR/G Protein
  3. GnRH Receptor
  4. T-98475

T-98475 (Compound 26d) is a potent, orally active, non-peptide luteinizing hormone-releasing hormone (LHRH) receptor antagonist with an IC50 of 0.2 nM.

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T-98475

T-98475 Estructura química

No. CAS : 199119-18-1

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T-98475 Related Antibodies

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Descripciòn

T-98475 (Compound 26d) is a potent, orally active, non-peptide luteinizing hormone-releasing hormone (LHRH) receptor antagonist with an IC50 of 0.2 nM[1].

IC50 & Target

IC50: 0.2 nM (human LHRH receptor), 2 nM (monkey LHRH receptor), 4 nM (monkey anterior pituitaries), 60 nM (rat anterior pituitaries)[1]
Cellular Effect
Cell Line Type Value Description References
CHO IC50
0.2 nM
Compound: 26d, T-98475
Inhibition of [125I]leuprorelin binding to human recombinant LHRH receptor expressed in CHO cells
Inhibition of [125I]leuprorelin binding to human recombinant LHRH receptor expressed in CHO cells
[PMID: 16789738]
CHO IC50
0.6 nM
Compound: 26d, T-98475
Inhibition of LHRH-stimulated arachidonic acid release in CHO cells expressing human LHRH receptor
Inhibition of LHRH-stimulated arachidonic acid release in CHO cells expressing human LHRH receptor
[PMID: 16789738]
CHO IC50
2 nM
Compound: 26d, T-98475
Inhibition of [125I]leuprorelin binding to monkey recombinant LHRH receptor expressed in CHO cells
Inhibition of [125I]leuprorelin binding to monkey recombinant LHRH receptor expressed in CHO cells
[PMID: 16789738]
Peso molecular

657.77

Fòrmula

C37H37F2N3O4S
No. CAS
SMILES

O=C(C1=CN(CC2=C(F)C=CC=C2F)C3=C(C1=O)C(CN(CC4=CC=CC=C4)C)=C(C5=CC=C(NC(C(C)C)=O)C=C5)S3)OC(C)C
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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T-98475 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

T-98475199119-18-1T98475T 98475GnRH ReceptorGonadotropin releasing hormone receptorGNRHRorally activenon-peptideInhibitorinhibitorinhibit

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Nombre del producto:
T-98475
Cat. No.:
HY-107533
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