1. PROTAC
  2. PROTAC Linkers
  3. Tetraethylene glycol monomethyl ether

Tetraethylene glycol monomethyl ether 

Cat. No.: HY-W018365 Purity: 98.51%
COA Handling Instructions

Tetraethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Tetraethylene glycol monomethyl ether Chemical Structure

Tetraethylene glycol monomethyl ether Chemical Structure

CAS No. : 23783-42-8

Size Price Stock Quantity
100 mg USD 30 In-stock
500 mg USD 40 In-stock
1 g USD 50 In-stock
5 g   Get quote  
10 g   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

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Description

Tetraethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

208.25

Formula

C9H20O5

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

COCCOCCOCCOCCO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (480.19 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8019 mL 24.0096 mL 48.0192 mL
5 mM 0.9604 mL 4.8019 mL 9.6038 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.35%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.8019 mL 24.0096 mL 48.0192 mL 120.0480 mL
5 mM 0.9604 mL 4.8019 mL 9.6038 mL 24.0096 mL
10 mM 0.4802 mL 2.4010 mL 4.8019 mL 12.0048 mL
15 mM 0.3201 mL 1.6006 mL 3.2013 mL 8.0032 mL
20 mM 0.2401 mL 1.2005 mL 2.4010 mL 6.0024 mL
25 mM 0.1921 mL 0.9604 mL 1.9208 mL 4.8019 mL
30 mM 0.1601 mL 0.8003 mL 1.6006 mL 4.0016 mL
40 mM 0.1200 mL 0.6002 mL 1.2005 mL 3.0012 mL
50 mM 0.0960 mL 0.4802 mL 0.9604 mL 2.4010 mL
60 mM 0.0800 mL 0.4002 mL 0.8003 mL 2.0008 mL
80 mM 0.0600 mL 0.3001 mL 0.6002 mL 1.5006 mL
100 mM 0.0480 mL 0.2401 mL 0.4802 mL 1.2005 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Tetraethylene glycol monomethyl ether Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Tetraethylene glycol monomethyl ether
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