2. Metabolic Enzyme/Protease
  3. Tyrosinase
  4. Tyrosinase-IN-50

Tyrosinase-IN-50 (Compound 14) is a Tyrosinase inhibitor (IC50 is 0.06 μM or 0.16 μM). Tyrosinase-IN-50 inhibits melanogenesis in multiple cell types. Tyrosinase-IN-50 can be used for the research of hyperpigmentation-related diseases and inflammatory diseases.

For research use only. We do not sell to patients.

Tyrosinase-IN-50

Tyrosinase-IN-50 Chemical Structure

CAS No. : 3081328-14-2

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Tyrosinase-IN-50 Related Antibodies

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Description

Tyrosinase-IN-50 (Compound 14) is a Tyrosinase inhibitor (IC50 is 0.06 μM or 0.16 μM). Tyrosinase-IN-50 inhibits melanogenesis in multiple cell types. Tyrosinase-IN-50 can be used for the research of hyperpigmentation-related diseases and inflammatory diseases[1].

In Vitro

Tyrosinase-IN-50 (5 min) exhibits an IC50 of 0.06 μM against tyrosinase in MNT-1 melanoma cells and an IC50 of 0.16 μM against tyrosinase in B16-F10 mouse skin melanoma cells[1].
Tyrosinase-IN-50 (1-10 μM; 6 days) inhibits melanogenesis in MNT-1 human melanoma cells in a concentration-dependent manner, with the melanin content at 10 μM being only 9.57% of that in the untreated group[1].
Tyrosinase-IN-50 (3.2-10000 μM) exhibits concentration-dependent DPPH radical scavenging activity, with the maximum scavenging rate reaching up to 49.45% at 10000 μM[1].
Tyrosinase-IN-50 (10 μM; 48 h) enhances the activity of the ARE/NRF2 reporter gene in HEK293T cells[1].
Tyrosinase-IN-50 (3-30 μM; 2 h) exerts a dose-dependent anti-inflammatory effect in LPS-induced RAW264.7 mouse macrophages[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tyrosinase-IN-50 Related Antibodies

Real Time qPCR[1]

Cell Line: RAW264.7 mouse macrophage cell line
Concentration: 3-30 μM
Incubation Time: 2 h (pretreatment); 16 h (LPS treatment)
Result: Downregulated the LPS-induced expression of IL-1α, IL-6, and TNF-α in a dose-dependent manner at concentrations of 3 μM, 10 μM, and 30 μM.
Molecular Weight

306.34

Formula

C14H14N2O4S
CAS No.
SMILES

O=C(NC1=NC(=CS1)C=2C=CC(O)=CC2O)C3(C)COC3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tyrosinase-IN-50 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tyrosinase-IN-503081328-14-2TyrosinaseHEK293T cellsRAW264.7 mouse macrophagesMNT-1 human melanoma cellshuman tyrosinaseIL-6B16-F10 mouse skin melanoma cellsmouse tyrosinaseIL-1αmelanogenesishyperpigmentation disordersInhibitorinhibitorinhibit

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