Tyrosinase-IN-50
Tyrosinase-IN-50 (Compound 14) is a Tyrosinase inhibitor (IC50 is 0.06 μM or 0.16 μM). Tyrosinase-IN-50 inhibits melanogenesis in multiple cell types. Tyrosinase-IN-50 can be used for the research of hyperpigmentation-related diseases and inflammatory diseases.
For research use only. We do not sell to patients.
- CAS No.: 3081328-14-2
- Formula: C14H14N2O4S
- Molecular Weight:306.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Tyrosinase-IN-50 (5 min) exhibits an IC50 of 0.06 μM against tyrosinase in MNT-1 melanoma cells and an IC50 of 0.16 μM against tyrosinase in B16-F10 mouse skin melanoma cells[1].
Tyrosinase-IN-50 (1-10 μM; 6 days) inhibits melanogenesis in MNT-1 human melanoma cells in a concentration-dependent manner, with the melanin content at 10 μM being only 9.57% of that in the untreated group[1].
Tyrosinase-IN-50 (3.2-10000 μM) exhibits concentration-dependent DPPH radical scavenging activity, with the maximum scavenging rate reaching up to 49.45% at 10000 μM[1].
Tyrosinase-IN-50 (10 μM; 48 h) enhances the activity of the ARE/NRF2 reporter gene in HEK293T cells[1].
Tyrosinase-IN-50 (3-30 μM; 2 h) exerts a dose-dependent anti-inflammatory effect in LPS-induced RAW264.7 mouse macrophages[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW264.7 mouse macrophage cell line
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Concentration:3-30 μM
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Incubation Time:2 h (pretreatment); 16 h (LPS treatment)
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Result:Downregulated the LPS-induced expression of IL-1α, IL-6, and TNF-α in a dose-dependent manner at concentrations of 3 μM, 10 μM, and 30 μM.
Chemical Information
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CAS No. 3081328-14-2
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Molecular Weight 306.34
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Formula C14H14N2O4S
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SMILES
O=C(NC1=NC(=CS1)C=2C=CC(O)=CC2O)C3(C)COC3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tyrosinase-IN-50 Related Classifications
HY-182989 Related Classifications
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