Notch1 - notch 1 Gene

Also Known as N1; Mis6; Tan1; lin-12; 9930111A19Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18128

About Notch1

Chromosome 2: 26,347,915-26,406,675 reverse strand.GRCm39:CM000995.3

This gene has 11 transcripts (splice variants), 273 orthologues, 4 paralogues and is associated with 55 phenotypes. Broad expression in thymus adult (RPKM 56.2), lung adult (RPKM 46.1) and 21 other tissues.

Summary

Enables several functions, including Notch binding activity; chromatin DNA binding activity; and transcription coactivator activity. Involved in several processes, including blood vessel endothelial cell differentiation; heart development; and negative regulation of cell differentiation. Acts upstream of or within several processes, including animal organ development; nervous system development; and tube morphogenesis. Located in several cellular components, including adherens junction; apical plasma membrane; and cell surface. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome; adult T-cell leukemia; and aortic valve disease 1. Orthologous to human NOTCH1 (Notch receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Notch1 Products (1)

mRNA	Protein	Name
NM_008714.3	NP_032740.3	neurogenic locus notch homolog protein 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables Notch binding	IPI IPI: Inferred from physical interaction	24667410	MGI
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	17658278	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	15689374	MGI
enables enzyme binding	IPI IPI: Inferred from physical interaction	17573339	MGI
enables enzyme inhibitor activity	IDA IDA: Inferred from direct assay	17573339	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8749394	MGI
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	9111338	MGI
enables transcription regulator activator activity	IDA IDA: Inferred from direct assay	18299578	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within Notch signaling pathway	IDA IDA: Inferred from direct assay	21419176	MGI
involved in Notch signaling pathway	IGI IGI: Inferred from genetic interaction	20890042	MGI
acts upstream of or within Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	19154718	MGI
involved in Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	14701881	MGI
acts upstream of or within Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation	IMP IMP: Inferred from mutant phenotype	19620969	MGI
involved in T-helper 17 type immune response	IDA IDA: Inferred from direct assay	28561022	MGI
acts upstream of or within anagen	IMP IMP: Inferred from mutant phenotype	15978571	MGI
involved in aortic valve morphogenesis	IGI IGI: Inferred from genetic interaction	23583836	MGI
involved in aortic valve morphogenesis	IMP IMP: Inferred from mutant phenotype	26491108	MGI
acts upstream of apoptotic process	IDA IDA: Inferred from direct assay	15081359	MGI
acts upstream of or within apoptotic process involved in embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	16245338	MGI
involved in arterial endothelial cell differentiation	IMP IMP: Inferred from mutant phenotype	15107403	MGI
involved in atrioventricular node development	IMP IMP: Inferred from mutant phenotype	21266778	MGI
involved in atrioventricular valve morphogenesis	IMP IMP: Inferred from mutant phenotype	14701881	MGI
acts upstream of or within auditory receptor cell fate commitment	IMP IMP: Inferred from mutant phenotype	19154718	MGI
acts upstream of or within axonogenesis	IDA IDA: Inferred from direct assay	15598981	MGI
acts upstream of or within axonogenesis	IMP IMP: Inferred from mutant phenotype	16120638	MGI
acts upstream of or within branching morphogenesis of an epithelial tube	IMP IMP: Inferred from mutant phenotype	15064243	MGI
acts upstream of calcium-ion regulated exocytosis	IMP IMP: Inferred from mutant phenotype	19251639	MGI
involved in cardiac atrium morphogenesis	IMP IMP: Inferred from mutant phenotype	20890042	MGI
involved in cardiac chamber formation	IMP IMP: Inferred from mutant phenotype	20890042	MGI
involved in cardiac epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	17303760	MGI
involved in cardiac left ventricle morphogenesis	IMP IMP: Inferred from mutant phenotype	20890042	MGI
involved in cardiac muscle cell myoblast differentiation	IMP IMP: Inferred from mutant phenotype	20007915	MGI
involved in cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	21311046	MGI
involved in cardiac muscle tissue morphogenesis	IMP IMP: Inferred from mutant phenotype	20007915	MGI
involved in cardiac right atrium morphogenesis	IMP IMP: Inferred from mutant phenotype	20007915	MGI
acts upstream of or within cardiac right ventricle formation	IMP IMP: Inferred from mutant phenotype	19620969	MGI
involved in cardiac septum morphogenesis	IMP IMP: Inferred from mutant phenotype	20007915	MGI
involved in cardiac vascular smooth muscle cell development	IMP IMP: Inferred from mutant phenotype	21311046	MGI
involved in cardiac ventricle morphogenesis	IMP IMP: Inferred from mutant phenotype	21311046	MGI
acts upstream of or within cell differentiation	IMP IMP: Inferred from mutant phenotype	14657333	MGI
involved in cell migration involved in endocardial cushion formation	IMP IMP: Inferred from mutant phenotype	20890042	MGI
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	15509736	MGI
involved in cellular response to hypoxia	IDA IDA: Inferred from direct assay	18299578	MGI
involved in chemical synaptic transmission, postsynaptic	IDA IDA: Inferred from direct assay	21315255	MGI
involved in chemical synaptic transmission, postsynaptic	IMP IMP: Inferred from mutant phenotype	21315255	MGI
involved in collecting duct development	IEP IEP: Inferred from expression pattern	15821257	MGI
acts upstream of or within compartment pattern specification	IMP IMP: Inferred from mutant phenotype	12001066	MGI
involved in coronary artery morphogenesis	IMP IMP: Inferred from mutant phenotype	21311046	MGI
involved in coronary sinus valve morphogenesis	IMP IMP: Inferred from mutant phenotype	26491108	MGI
involved in coronary vein morphogenesis	IMP IMP: Inferred from mutant phenotype	21311046	MGI
acts upstream of or within determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	7789282	MGI
involved in distal tubule development	IEP IEP: Inferred from expression pattern	15821257	MGI
acts upstream of or within embryonic hindlimb morphogenesis	IMP IMP: Inferred from mutant phenotype	16245338	MGI
acts upstream of or within embryonic limb morphogenesis	IGI IGI: Inferred from genetic interaction	16169548	MGI
involved in endocardial cell differentiation	IMP IMP: Inferred from mutant phenotype	20890042	MGI
acts upstream of or within endocardial cushion development	IMP IMP: Inferred from mutant phenotype	14701881	MGI
involved in endocardial cushion morphogenesis	IGI IGI: Inferred from genetic interaction	27107132	MGI
involved in endocardial cushion morphogenesis	IMP IMP: Inferred from mutant phenotype	14701881	MGI
involved in endocardium development	IMP IMP: Inferred from mutant phenotype	17336907	MGI
involved in endocardium morphogenesis	IEP IEP: Inferred from expression pattern	16025100	MGI
involved in endocardium morphogenesis	IMP IMP: Inferred from mutant phenotype	20890042	MGI
acts upstream of or within endoderm development	IMP IMP: Inferred from mutant phenotype	14657333	MGI
acts upstream of or within epidermal cell fate specification	IMP IMP: Inferred from mutant phenotype	15068794	MGI
acts upstream of or within epidermis development	IGI IGI: Inferred from genetic interaction	15525534	MGI
acts upstream of or within epithelial cell fate commitment	IMP IMP: Inferred from mutant phenotype	16107537	MGI
acts upstream of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	15509736	MGI
acts upstream of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	25535395	MGI
acts upstream of or within epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	14701881	MGI
involved in epithelial to mesenchymal transition involved in endocardial cushion formation	IMP IMP: Inferred from mutant phenotype	14701881	MGI
acts upstream of or within forebrain development	IGI IGI: Inferred from genetic interaction	16120638	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	16120638	MGI
acts upstream of or within foregut morphogenesis	IMP IMP: Inferred from mutant phenotype	16107537	MGI
involved in gene expression	IDA IDA: Inferred from direct assay	28561022	MGI
acts upstream of or within glial cell differentiation	IMP IMP: Inferred from mutant phenotype	15965470	MGI
involved in glomerular mesangial cell development	IEP IEP: Inferred from expression pattern	15821257	MGI
involved in growth involved in heart morphogenesis	IMP IMP: Inferred from mutant phenotype	20007915	MGI
acts upstream of or within hair follicle morphogenesis	IMP IMP: Inferred from mutant phenotype	15525534	MGI
involved in heart looping	IGI IGI: Inferred from genetic interaction	12730124	MGI
involved in heart trabecula morphogenesis	IMP IMP: Inferred from mutant phenotype	20890042	MGI
involved in homeostasis of number of cells within a tissue	IGI IGI: Inferred from genetic interaction	27107132	MGI
acts upstream of or within humoral immune response	IGI IGI: Inferred from genetic interaction	17658279	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	7789282	MGI
acts upstream of or within inflammatory response to antigenic stimulus	IGI IGI: Inferred from genetic interaction	17658279	MGI
acts upstream of or within inhibition of neuroepithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	15064243	MGI
involved in interleukin-17-mediated signaling pathway	IDA IDA: Inferred from direct assay	28561022	MGI
acts upstream of or within interleukin-4 production	IGI IGI: Inferred from genetic interaction	17658279	MGI
acts upstream of keratinocyte differentiation	IGI IGI: Inferred from genetic interaction	16618808	MGI
acts upstream of or within keratinocyte differentiation	IMP IMP: Inferred from mutant phenotype	15068794	MGI
involved in left/right axis specification	IGI IGI: Inferred from genetic interaction	12730124	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	15226394	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	15064243	MGI
involved in mesenchymal cell development	IMP IMP: Inferred from mutant phenotype	17303760	MGI
involved in negative regulation of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	19695258	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16025100	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19695258	MGI
involved in negative regulation of biomineral tissue development	IDA IDA: Inferred from direct assay	23583836	MGI
involved in negative regulation of biomineral tissue development	IMP IMP: Inferred from mutant phenotype	26491108	MGI
acts upstream of or within negative regulation of calcium ion-dependent exocytosis	IMP IMP: Inferred from mutant phenotype	19251639	MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	19620969	MGI
involved in negative regulation of cardiac muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	26491108	MGI
involved in negative regulation of catalytic activity	IDA IDA: Inferred from direct assay	17573339	MGI
involved in negative regulation of cell proliferation involved in heart valve morphogenesis	IDA IDA: Inferred from direct assay	26491108	MGI
involved in negative regulation of cell proliferation involved in heart valve morphogenesis	IMP IMP: Inferred from mutant phenotype	26491108	MGI
involved in negative regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	25038826	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	25535395	MGI
involved in negative regulation of extracellular matrix constituent secretion	IMP IMP: Inferred from mutant phenotype	26491108	MGI
involved in negative regulation of glial cell proliferation	IDA IDA: Inferred from direct assay	12666205	MGI
acts upstream of or within negative regulation of inner ear auditory receptor cell differentiation	IMP IMP: Inferred from mutant phenotype	25535395	MGI
involved in negative regulation of myotube differentiation	IMP IMP: Inferred from mutant phenotype	18299578	MGI
involved in negative regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	18299578	MGI
acts upstream of or within negative regulation of neuron differentiation	IGI IGI: Inferred from genetic interaction	10205173	MGI
acts upstream of or within negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	15064243	MGI
involved in negative regulation of oligodendrocyte differentiation	IDA IDA: Inferred from direct assay	12666205	MGI
involved in negative regulation of ossification	IMP IMP: Inferred from mutant phenotype	21493891	MGI
involved in negative regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	19695258	MGI
acts upstream of or within negative regulation of photoreceptor cell differentiation	IMP IMP: Inferred from mutant phenotype	16452096	MGI
involved in negative regulation of pro-B cell differentiation	IMP IMP: Inferred from mutant phenotype	12032823	MGI
acts upstream of or within negative regulation of programmed cell death	IMP IMP: Inferred from mutant phenotype	7789282	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12032823	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	14701881	MGI
acts upstream of or within neural tube development	IMP IMP: Inferred from mutant phenotype	7789282	MGI
acts upstream of neuroendocrine cell differentiation	IMP IMP: Inferred from mutant phenotype	15064243	MGI
acts upstream of neuron differentiation	IGI IGI: Inferred from genetic interaction	10205173	MGI
acts upstream of neuron differentiation	IMP IMP: Inferred from mutant phenotype	16120638	MGI
acts upstream of or within neuron differentiation	IMP IMP: Inferred from mutant phenotype	9102301	MGI
acts upstream of or within neuron fate commitment	IGI IGI: Inferred from genetic interaction	16120638	MGI
acts upstream of or within oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	12186854	MGI
involved in pericardium morphogenesis	IMP IMP: Inferred from mutant phenotype	14701881	MGI
involved in positive regulation of BMP signaling pathway	IDA IDA: Inferred from direct assay	20547764	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9111338	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12666205	MGI
acts upstream of or within positive regulation of Notch signaling pathway	IDA IDA: Inferred from direct assay	24667410	MGI
acts upstream of or within positive regulation of aorta morphogenesis	IMP IMP: Inferred from mutant phenotype	18952909	MGI
acts upstream of or within positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	15081359	MGI
acts upstream of or within positive regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	16169548	MGI
involved in positive regulation of apoptotic process involved in morphogenesis	IDA IDA: Inferred from direct assay	26491108	MGI
involved in positive regulation of astrocyte differentiation	IDA IDA: Inferred from direct assay	12666205	MGI
involved in positive regulation of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	20007915	MGI
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	20890042	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	15509736	MGI
involved in positive regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	20890042	MGI
involved in positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	23583836	MGI
acts upstream of or within positive regulation of keratinocyte differentiation	IDA IDA: Inferred from direct assay	17079689	MGI
acts upstream of or within positive regulation of keratinocyte differentiation	IGI IGI: Inferred from genetic interaction	16618808	MGI
involved in positive regulation of receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	15156153	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12783854	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19245366	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16618808	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	14701881	MGI
acts upstream of or within positive regulation of transcription of Notch receptor target	IGI IGI: Inferred from genetic interaction	12794108	MGI
involved in positive regulation of viral genome replication	IMP IMP: Inferred from mutant phenotype	21191019	MGI
involved in positive regulation of viral transcription	IMP IMP: Inferred from mutant phenotype	21191019	MGI
acts upstream of or within prostate gland epithelium morphogenesis	IMP IMP: Inferred from mutant phenotype	16360140	MGI
involved in protein catabolic process	IDA IDA: Inferred from direct assay	28561022	MGI
involved in protein import into nucleus	IDA IDA: Inferred from direct assay	28561022	MGI
involved in pulmonary valve morphogenesis	IGI IGI: Inferred from genetic interaction	27107132	MGI
involved in pulmonary valve morphogenesis	IMP IMP: Inferred from mutant phenotype	26491108	MGI
acts upstream of or within regulation of Notch signaling pathway	IGI IGI: Inferred from genetic interaction	24667410	MGI
involved in regulation of cell adhesion involved in heart morphogenesis	IMP IMP: Inferred from mutant phenotype	14701881	MGI
involved in regulation of cell migration	IMP IMP: Inferred from mutant phenotype	20890042	MGI
acts upstream of or within regulation of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	25535395	MGI
acts upstream of or within regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	16107537	MGI
acts upstream of or within regulation of epithelial cell proliferation involved in prostate gland development	IMP IMP: Inferred from mutant phenotype	16360140	MGI
involved in regulation of extracellular matrix assembly	IMP IMP: Inferred from mutant phenotype	21311046	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	9102301	MGI
acts upstream of or within regulation of inner ear auditory receptor cell differentiation	IMP IMP: Inferred from mutant phenotype	25535395	MGI
acts upstream of or within regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	9102301	MGI
involved in regulation of postsynaptic neurotransmitter receptor activity	IDA IDA: Inferred from direct assay	26635527	MGI
involved in regulation of postsynaptic neurotransmitter receptor activity	IMP IMP: Inferred from mutant phenotype	26635527	MGI
acts upstream of or within regulation of somitogenesis	IMP IMP: Inferred from mutant phenotype	7789282	MGI
acts upstream of or within regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	16107537	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15689374	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	25535395	MGI
involved in regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20007915	MGI
involved in response to muramyl dipeptide	IDA IDA: Inferred from direct assay	21156799	MGI
acts upstream of retinal cone cell differentiation	IMP IMP: Inferred from mutant phenotype	16452096	MGI
acts upstream of or within secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	IMP IMP: Inferred from mutant phenotype	16360140	MGI
acts upstream of or within skeletal muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	22147266	MGI
acts upstream of or within somatic stem cell division	IDA IDA: Inferred from direct assay	12717450	MGI
acts upstream of or within somatic stem cell division	IGI IGI: Inferred from genetic interaction	15509736	MGI
acts upstream of or within sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	15809373	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16618808	MGI
acts upstream of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16618808	MGI
involved in vasculogenesis involved in coronary vascular morphogenesis	IMP IMP: Inferred from mutant phenotype	21311046	MGI
acts upstream of or within venous blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	18952909	MGI
involved in venous endothelial cell differentiation	IMP IMP: Inferred from mutant phenotype	20890042	MGI
involved in ventricular septum morphogenesis	IGI IGI: Inferred from genetic interaction	27107132	MGI
involved in ventricular septum morphogenesis	IMP IMP: Inferred from mutant phenotype	26491108	MGI
involved in ventricular trabecula myocardium morphogenesis	IMP IMP: Inferred from mutant phenotype	17336907	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	21315255	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	21315255	MGI
located in adherens junction	IDA IDA: Inferred from direct assay	24715457	MGI
located in apical plasma membrane	IDA IDA: Inferred from direct assay	24715457	MGI
located in cell periphery	IDA IDA: Inferred from direct assay	23284756	MGI
located in cell surface	IDA IDA: Inferred from direct assay	15574878	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	15965470	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	24667410	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	24667410	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	26635527	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	26635527	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10206645	MGI
located in nucleus	IMP IMP: Inferred from mutant phenotype	20007915	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	17079689	MGI
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	21315255	MGI
is active in postsynaptic density membrane	IEP IEP: Inferred from expression pattern	21315255	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Notch1 Protein Structure

EGF_CA

Notch

NOD

NODP

JMTM_Notch1

ANKYR

ANK

ANKYR

Ank_2

ANK

PHA03247

0
400
800
1200
1600
2000
2400
2531 a.a.

Protein Preferred Names	Protein Names
neurogenic locus notch homolog protein 1	Motch A Notch gene homolog 1 mT14 major type A protein p300

Recombinant Notch1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71166	NOTCH1 Protein, Mouse (HEK293, His)	Q01705 (A18-Q526)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73324	NOTCH1 Protein, Mouse (sf9, His)	Q01705 (A19-Q526)	≥ 85%, as determined by reducing SDS-PAGE.
HY-P79173	NOTCH1 Protein, Mouse (CHO, mFc)	AAM28905 (A19-Q526)	≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Purity	Rare Diseases
HY-10585	Valproic acid	99.90%	Unkown
HY-10585A	Valproic acid sodium	99.65%	Unkown
HY-10585AR	Valproic acid sodium (Standard)	98.92%	Unkown
HY-10585B	Valproic acid sodium (2:1)	/	Unkown

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-N0711	Carvacrol		99.98%	Phase 3
HY-W794759	Valproic acid magnesium		/	Phase 3
HY-15670	BMS-906024	Inhibitor	99.91%	Phase 1
HY-12860	BMS-986115	Inhibitor	99.90%	Phase 1
HY-141876	PRT543		/	Phase 1

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99258	Brontictuzumab	Inhibitor	95.00%	Phase 1
HY-P991423	MEDI0639	Inhibitor	98.78%	Phase 1

Pre-clinical Phase

Bioactive Molecules (38)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13027	DAPT		99.97%	Unkown
HY-N0133	Tangeretin		99.36%	Unkown
HY-134978A	(+)SHIN2	Inhibitor	99.30%	Unkown
HY-N0232	Psoralidin		99.90%	Unkown
HY-124284	Hexamethylene bisacetamide		99.56%	Unkown
HY-N5112B	β,β-Dimethylacrylshikonin		99.30%	Unkown
HY-14174	MRK-560	Inhibitor	99.92%	Unkown
HY-10585R	Valproic acid (Standard)		99.97%	Unkown
HY-164404	NADI-351	Inhibitor	99.83%	Unkown
HY-10585S2	Valproic acid-d15		99.80%	Unkown
HY-N1510	Kaempferol 3-O-gentiobioside	Inhibitor	99.88%	Unkown
HY-10585S1	Valproic acid-d6		99.83%	Unkown
HY-144899	ASR-490	Inhibitor	99.20%	Unkown
HY-10585S	Valproic acid-d4		98.0%	Unkown
HY-12465	Z-Ile-Leu-aldehyde		97.0%	Unkown
HY-N11709	Theasaponin E1		99.08%	Unkown
HY-N2896	Arjunolic acid		98.83%	Unkown
HY-10585S4	Valproic acid-d4-1		99.5%	Unkown
HY-P1985	Notch 1		95.39%	Unkown
HY-10585AS1	Valproic acid-d14 sodium		96.73%	Unkown
HY-164466	CAD204520	Inhibitor	99.22%	Unkown
HY-164466A	CAD204520 dihydrochloride	Inhibitor	99.26%	Unkown
HY-P1985A	Notch 1 TFA		/	Unkown
HY-RS09445	NOTCH1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-183626	PAI-1-IN-1		99.45%	Unkown
HY-10585AS	Valproic acid-d7 sodium		/	Unkown
HY-103539	3,5-Bis(4-nitrophenoxy)benzoic acid	Inhibitor	98.50%	Unkown
HY-10585AG	Valproic acid sodium (GMP)		/	Unkown
HY-10585S3	Valproic acid-d4 sodium		/	Unkown
HY-118900	CP-654577		/	Unkown
HY-120372	BMS-871	Inhibitor	/	Unkown
HY-181975	ATOX1-IN-1	Inhibitor	/	Unkown
HY-E70178	Protein O-Glucosyltransferase 1		/	Unkown
HY-N9790	Procyanidin B2 3,3'-di-O-gallate	Inhibitor	/	Unkown
HY-RS09446	Notch1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09447	Notch1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N12768	Rhodojaponin VI	Inhibitor	99.78%	Unkown
HY-W714200	Neburon		/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991328	MAb604.107	Inhibitor	/	Unkown
HY-P992275	Anti-Nicastrin Antibody (A5226A)	Inhibitor	/	Unkown
HY-P990476	Anti-NOTCH1 Antibody	Inhibitor	98.67%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Notch1	NCBI	NCBI:4851