Neburon

Neburon (0.1-10 μg/L; waterborne exposure; daily solution refresh; 72 hours) induces dose-dependent cardiotoxicity in Danio rerio embryos, with 10 μg/L causing significant cardiac malformations, tachycardia, and impaired systolic function, and these effects are mediated via the Ahr and Notch1 signaling pathways^[1].
Neburon (0.1-10 μg/L; waterborne exposure; solution refresh every other day; 150 days) induces dose-dependent structural and functional cardiac damage in adult male zebrafish, with even 0.1 μg/L causing ventricular enlargement, wall thickening, and fibrosis, and these effects involve activation of the Ahr and Notch1 signaling pathways^[1].
Neburon (0.1-10 μg/L; waterborne; daily renewal (first month), every 2 days (remaining duration); 150 days) induces dose-dependent male reproductive toxicity in zebrafish, including impaired courtship behavior, reduced fecundity, disrupted spermatogenesis, hormonal imbalances, altered HPG axis gene expression, AhR pathway activation, oxidative stress, and increased testicular apoptosis, with the 10 μg/L dose producing the most severe effects^[2].