Neburon 

Neburon is a phenylurea herbicide whose main mechanism of action is to inhibit photosynthetic electron transport, thereby disrupting algal growth. Neburon activates the Ahr and Notch1 signaling pathways, and induces oxidative stress and apoptosis. Long-term exposure causes significant male reproductive toxicity and cardiotoxicity in zebrafish^[1][2].

Neburon (0.1-10 μg/L; waterborne exposure; daily solution refresh; 72 hours) induces dose-dependent cardiotoxicity in Danio rerio embryos, with 10 μg/L causing significant cardiac malformations, tachycardia, and impaired systolic function, and these effects are mediated via the Ahr and Notch1 signaling pathways^[1].
Neburon (0.1-10 μg/L; waterborne exposure; solution refresh every other day; 150 days) induces dose-dependent structural and functional cardiac damage in adult male zebrafish, with even 0.1 μg/L causing ventricular enlargement, wall thickening, and fibrosis, and these effects involve activation of the Ahr and Notch1 signaling pathways^[1].
Neburon (0.1-10 μg/L; waterborne; daily renewal (first month), every 2 days (remaining duration); 150 days) induces dose-dependent male reproductive toxicity in zebrafish, including impaired courtship behavior, reduced fecundity, disrupted spermatogenesis, hormonal imbalances, altered HPG axis gene expression, AhR pathway activation, oxidative stress, and increased testicular apoptosis, with the 10 μg/L dose producing the most severe effects^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

275.17

C₁₂H₁₆Cl₂N₂O

555-37-3

O=C(NC1=CC=C(Cl)C(Cl)=C1)N(C)CCCC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Tang C, et al. Neburon induced cardiotoxicity in embryonic and adult male zebrafish via over-activation of the Ahr-Notch1 signaling pathway. Environ Pollut. 2025;382:126684.  [Content Brief]

  [2]. Zhang F, et al. Long-term exposure to aryl hydrocarbon receptor agonist neburon induces reproductive toxicity in male zebrafish (Danio rerio). J Environ Sci (China). 2024;142:193-203.  [Content Brief]