555-37-3
555-37-3
Chemical Structure
Neburon
- CAS. Nr.: 555-37-3
- Formula:C12H16Cl2N2O
- Molecular Weight:275.17
IUPAC Name: 1-butyl-3-(3,4-dichlorophenyl)-1-methylurea
InChIKey: CCGPUGMWYLICGL-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(Cl)C(Cl)=C1)N(C)CCCC
Biological Activity: Neburon is a phenylurea herbicide whose main mechanism of action is to inhibit photosynthetic electron transport, thereby disrupting algal growth. Neburon activates the Ahr and Notch1 signaling pathways, and induces oxidative stress and apoptosis. Long-term exposure causes significant male reproductive toxicity and cardiotoxicity in zebrafish[1][2].
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Neburon | Neburon is a phenylurea herbicide whose main mechanism of action is to inhibit photosynthetic electron transport, thereby disrupting algal growth. Neburon activates the Ahr and Notch1 signaling pathways, and induces oxidative stress and apoptosis. Long-term exposure causes significant male reproductive toxicity and cardiotoxicity in zebrafish. | |||||||||||||||||||||
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References
- [1]. Tang C, et al. Neburon induced cardiotoxicity in embryonic and adult male zebrafish via over-activation of the Ahr-Notch1 signaling pathway. Environ Pollut. 2025;382:126684. [Content Brief]
- [2]. Zhang F, et al. Long-term exposure to aryl hydrocarbon receptor agonist neburon induces reproductive toxicity in male zebrafish (Danio rerio). J Environ Sci (China). 2024;142:193-203. [Content Brief]
Keywords
