VEGFR-2-IN-21
VEGFR-2-IN-21 (Compound 5d) is a potent VEGFR-2 inhibitor with an IC50 of 0.10 μM. VEGFR-2-IN-21 shows anticancer activity.
For research use only. We do not sell to patients.
- CAS No.: 2531029-88-4
- Formula: C28H24ClN7O3S
- Molecular Weight:574.05
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All VEGFR Isoforms
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Biological Activity
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VEGFR-2 0.10 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
7.77 μM
Compound: 47
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Cytotoxicity against human HCT-116 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
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[PMID: 38728867] |
| HepG2 | IC50 |
8.98 μM
Compound: 47
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Cytotoxicity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by MTT assay
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[PMID: 38728867] |
| MCF7 | IC50 |
6.99 μM
Compound: 47
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Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38728867] |
VEGFR-2-IN-21 (Compound 5d) shows inhibitory activities against the three HepG2, HCT116 and MCF-7 cancer cell lines with IC50 values of 8.98 ± 0.1, 7.77 ± 0.1 and 6.99 ± 0.1 µM respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2531029-88-4
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Molecular Weight 574.05
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Formula C28H24ClN7O3S
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SMILES
O=S(C1=CC=C(/N=N/C2=CC=C(C3=NCC(N(C)C4=CC=C(Cl)C=C34)=O)C=C2)C=C1)(NC5=NC(C)=CC(C)=N5)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VEGFR-2-IN-21 Related Classifications
HY-147800 Related Classifications
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