Xanthine oxidase-IN-17
Xanthine oxidase-IN-17 is a potent xanthine oxidase (XOD) inhibitor with an IC50 of 298 nM and a Ki of 167 nM. Xanthine oxidase-IN-17 decreases the formation of O₂⁻ radical by inhibiting the catalytic activity of XOD to diminish the production of uric acid. Xanthine oxidase-IN-17 shows no cytotoxicity in AML-12 hepatocytes, while suppressing uric acid production. Xanthine oxidase-IN-17 can be used for the studies of hyperuricemia and subsequently to gout.
For research use only. We do not sell to patients.
- CAS No.: 185522-92-3
- Formula: C17H16O4
- Molecular Weight:284.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Xanthine oxidase-IN-17 (Compound 15b) (1-40 μM, 24 h) has no significant toxic effect on AML-12 at 20 μM and has resisted the production of uric acid but its uric acid lowering effect is much weaker than that of Febuxostat (HY-14268) at the same concentration [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 185522-92-3
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Molecular Weight 284.31
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Formula C17H16O4
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SMILES
COC1=CC=C(C(/C=C/C2=CC=C(O)C=C2)=O)C(OC)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Xanthine oxidase-IN-17 Related Classifications
HY-175303 Related Classifications
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