Xentry
Xentry is a cell-penetrating peptide (CCP) consisting of only 7 amino acids of hepatitis B virus: LCLRPVG. Xentry-linked anti-B-raf antibodies and siRNAs demonstrates the capability to kill B-raf-dependent melanoma cells. Xentry alone or conjugated to β-galactosidase leads to its delivery to most tissues in mice, except circulating blood cells. Xentry can be used for the delivery of large molecules (antibodies, siRNA, enzymes) .
For research use only. We do not sell to patients.
- CAS No.: 1352335-71-7
- Formula: C33H60N10O8S
- Molecular Weight:756.96
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Xentry (10 μM) penetrates adherent cells energy-dependently, including HepG2 (liver), C32 (melanoma), DU145 (prostate), H441 (lung), BT474 (breast), Cos (kidney), and Rin-m5F (pancreatic b-cell) cell lines, but not nonadherent resting blood cells[1].
Xentry (10-20 μM, 4 h) conjugated to β-galactosidase is internalized by living HepG2 cells, and enters cells via a syndecan pathway[1].
Xentry (1 h) effectively delivers antibodies and siRNA to melanoma cells, inducing apoptosis of B-raf-dependent melanoma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
TAMRA-labelled Xentry (2-100 μg/mL, i.v., single dose) successfully delivers the macromolecular complex to multiple tissues in Balb/c mice, specifically enriching in small intestinal epithelial cells and marginal sinus of the spleen[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1352335-71-7
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Molecular Weight 756.96
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Formula C33H60N10O8S
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Sequence
Leu-Cys-Leu-Arg-Pro-Val-Gly
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Sequence Shortening
LCLRPVG
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Xentry Related Classifications
HY-P11083 Related Classifications
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