ε-Poly-L-lysine hydrochloride (MV 2000-5000)  (Synonyms: Epsilon-polylysine hydrochloride (MV 2000-5000); ε-Polylysine hydrochloride (MV 2000-5000); ε-PL hydrochloride (MV 2000-5000))

ε-Poly-L-lysine (Epsilon-polylysine; ε-Polylysine) hydrochloride (MV 2000-5000) is a polycationic antibacterial agent with broad-spectrum activity against Gram-positive bacteria, Gram-negative bacteria, fungi, yeasts and specific bacteriophages. ε-Poly-L-lysine hydrochloride (MV 2000-5000) exerts bactericidal effects through mechanisms such as disrupting microbial membranes, inducing ROS production, inhibiting metabolism and spore germination. ε-Poly-L-lysine hydrochloride (MV 2000-5000) also regulates the expression of multiple key genes including sodA, oxyR and recA. ε-Poly-L-lysine hydrochloride (MV 2000-5000) exhibits properties such as low eukaryotic cytotoxicity, thermal stability and pH stability, and supports tissue regeneration and anti-tumor applications. ε-Poly-L-lysine hydrochloride (MV 2000-5000) can be applied in research fields including bacterial and fungal infections, diabetic ulcers, and methicillin-resistant Staphylococcus aureus infections^[1][2][3].

ε-Poly-L-lysine hydrochloride (MV 2000-5000) (2.5-12.5 μg/mL) inhibits spore germination of Geobacillus stearothermophilus at 2.5 μg/mL, and Bacillus coagulans and B. subtilis at 12.5 μg/mL^[1].
ε-Poly-L-lysine hydrochloride (MV 2000-5000) (500 μg/mL) significantly inactivates long-tailed, non-contractile double-stranded DNA bacteriophages, resulting in 0-27% survival rates^[1].
ε-Poly-L-lysine hydrochloride (MV 2000-5000) (25-200 μg/mL) inhibits Escherichia coli growth with an MIC of 25-50 μg/mL at pH 5.0-7.0, but its antimicrobial activity is significantly reduced at pH 8.0 (MIC >200 μg/mL)^[1].
ε-Poly-L-lysine hydrochloride (MV 2000-5000) exhibits a synergistic preservative effect when combined with 2 mg/mL glycine^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Catechol/ε-PLL (ε-Poly-L-lysine hydrochloride (MV 2000-5000)) hydrogels reduce bacterial burden in mouse burn wound infections^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2000-5000

(C₆H₁₂N₂O.ClH)n

Solid

White to off-white

CNC([C@H](CCCCC)N)=O.[n].Cl

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Yoshida T, Nagasawa T. ε-Poly-l-lysine: microbial production, biodegradation and application potential[J]. Applied microbiology and biotechnology, 2003, 62(1): 21-26.

  [2]. Lebaudy E, Guilbaud-Chéreau C, Frisch B, et al. The high potential of ε‐Poly‐l‐Lysine for the development of antimicrobial biomaterials[J]. Advanced NanoBiomed Research, 2023, 3(12):

  [3]. Ye R, Xu H, Wan C, et al. Antibacterial activity and mechanism of action of ε-poly-l-lysine[J]. Biochemical and biophysical research communications, 2013, 439(1): 148-153.