1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine
Based on 1 Customer Validation
1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine (16:1 PE) is a phosphatidylethanolamine that can enhance PP2A and PTP1B activities in malignant pleural mesothelioma cells. 1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine induces apoptosis of NCI-H28 malignant pleural mesothelioma cells.
For research use only. We do not sell to patients.
- Purity : 99%
- CAS No.: 61599-23-3
- Formula: C37H70NO8P
- Molecular Weight:687.93
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine (DPPE; 1-100 μM; 24-48 hours) reduces NCI-H28 cell viability in a concentration-dependent manner (1-100 μM), but has no effect on Met5A (non-malignant mesothelial cells) cells[1].
1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine (DPPE; 100 μM; 10-60 minutes) tends to attenuate activity ofERK1/ERK2[1].
1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine (DPPE; 30-100 μM; 48 hours) significantly increases TUNEL-positive NCI-H28 cells, indicating apoptosis, with minimal effect on Met5A[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NCI-H28 (Malignant pleural mesothelioma)
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Concentration:1 μM, 10 μM, 100 μM
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Incubation Time:24 hours, 48 hours
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Result:Reduced NCI-H28 cell viability in a concentration-dependent manner.
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Cell Line:NCI-H28 (Malignant pleural mesothelioma)
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Concentration:100 μM
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Incubation Time:10 minutes, 30 minutes, 60 minutes
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Result:Attenuated phosphorylation of ERK1/2 in NCI-H28 cells.
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Cell Line:NCI-H28 (Malignant pleural mesothelioma)
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Concentration:30 and 100 μM
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Incubation Time:48 hours
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Result:Induced apoptosis in NCI-H28 cells.
Chemical Information
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CAS No. 61599-23-3
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Appearance Solid
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Molecular Weight 687.93
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Formula C37H70NO8P
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Color White to off-white
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SMILES
CCCCCC/C=C\CCCCCCCC(O[C@@H](COP(OCCN)(O)=O)COC(CCCCCCC/C=C\CCCCCC)=O)=O
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Synonyms
16:1 PE
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine Related Classifications
HY-157673 Related Classifications
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