1-Oleoyl lysophosphatidylcholine 

1-Oleoyl lysophosphatidylcholine is a GPR119 activator and insulin secretion potentiator with a human GPR119 EC₅₀ of 1.5 μM.1-Oleoyl lysophosphatidylcholine acts as a bioactive lipid mediator with diverse physiological and pathological functions.1-Oleoyl lysophosphatidylcholine can be used for the research of diabetes^[1].

1-Oleoyl lysophosphatidylcholine (1-10 μM; 15-25 min) dose-dependently induces intracellular cAMP accumulation and insulin secretion in NIT-1 mouse pancreatic β-cells via adenylate cyclase activation, with significant effects observed at concentrations ≥3 μM^[1].
1-Oleoyl lysophosphatidylcholine (15 min) activates human GPR119 in RH7777 rat hepatoma cells, inducing dose-dependent intracellular cAMP accumulation with an EC₅₀ of 1.5 μM^[1].
1-Oleoyl lysophosphatidylcholine induced insulin secretion in NIT-1 mouse pancreatic β-cells is at least partially mediated by GPR119, as demonstrated by reduced secretion following siRNA-mediated knockdown of GPR119^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

521.67

C₂₆H₅₂NO₇P

3542-29-8

CCCCCCCC/C=C\CCCCCCCC(OCC(O)COP(OCC[N+](C)(C)C)([O-])=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Soga T, et al. Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor. Biochem Biophys Res Commun. 2005;326(4):744-751.  [Content Brief]