2,3-Diphosphoglyceric acid
2,3-Diphosphoglyceric acid (2,3-DPG) is an intermediate of the glycolytic pathway. 2,3-Diphosphoglyceric acid stabilizes the deoxygenated form of hemoglobin by allosteric binding and facilitates oxygen release at tissue sites. 2, 3-diphosphoglyceric acid has antiparasitic activity. 2,3-Diphosphoglyceric acid can be used in the study of Alzheimer's disease (AD).
For research use only. We do not sell to patients.
- CAS No.: 138-81-8
- Formula: C3H8O10P2
- Molecular Weight:266.04
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| T-cell | EC50 |
1580 μM
Compound: 2,3-diphosphoglycerate
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Effective concentration to activate gammadelta T cells
Effective concentration to activate gammadelta T cells
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[PMID: 12383012] |
2, 3-diphosphoglyceric acid (8 mM, 48 h) inhibits the development of Plasmodium falciparum[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 138-81-8
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Molecular Weight 266.04
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Formula C3H8O10P2
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SMILES
O=C(O)C(OP(O)(O)=O)COP(O)(O)=O
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Synonyms
2,3-DPG
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[2]. Płoszczyca K, et al. Red Blood Cell 2,3-Diphosphoglycerate Decreases in Response to a 30 km Time Trial Under Hypoxia in Cyclists. Front Physiol. 2021 Jun 15;12:670977. [Content Brief]
[3]. Morais I, et al. Synthetic Red Blood Cell-Specific Glycolytic Intermediate 2,3-Diphosphoglycerate (2,3-DPG) Inhibits Plasmodium falciparum Development In Vitro. Front Cell Infect Microbiol. 2022 Mar 15;12:840968. [Content Brief]
[4]. Kosenko EA, et al. Relationship between chronic disturbance of 2,3-diphosphoglycerate metabolism in erythrocytes and Alzheimer disease. CNS Neurol Disord Drug Targets. 2016;15(1):113-23. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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