2’-Deoxy-2’-fluoro-alpha-D-arabinoguanosine
2’-Deoxy-2’-fluoro-alpha-D-arabinoguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
For research use only. We do not sell to patients.
- CAS No.: 2072145-29-8
- Formula: C10H12FN5O4
- Molecular Weight:285.23
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEp-2 | EC50 |
>200 μM
Compound: 2'd2'FG
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Antiviral activity against RSV A2 infected in human Hep2 cells assessed as protection against virus-induced cytopathic effect after 4 days by Cell-Titer Glo assay
Antiviral activity against RSV A2 infected in human Hep2 cells assessed as protection against virus-induced cytopathic effect after 4 days by Cell-Titer Glo assay
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[PMID: 25978965] |
| HEp-2 | IC50 |
6.6 μM
Compound: 2'd2'FG
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Inhibition of RSV A2 RNA-dependent RNA polymerase expressed in human Hep2 cells using ATP, GTP, UTP, CTP and 1.5 uCi [alpha-32P] NTP as substrate assessed as reduction of total radiolabled transcript after 90 mins by agarose gel electrophoresis
Inhibition of RSV A2 RNA-dependent RNA polymerase expressed in human Hep2 cells using ATP, GTP, UTP, CTP and 1.5 uCi [alpha-32P] NTP as substrate assessed as reduction of total radiolabled transcript after 90 mins by agarose gel electrophoresis
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[PMID: 25978965] |
| MT4 | CC50 |
>49 μM
Compound: 2'd2'FG
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Cytotoxicity against human MT4 cells assessed as cell viability after 5 days by Cell-Titer Glo assay
Cytotoxicity against human MT4 cells assessed as cell viability after 5 days by Cell-Titer Glo assay
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[PMID: 25978965] |
Chemical Information
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CAS No. 2072145-29-8
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Molecular Weight 285.23
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Formula C10H12FN5O4
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SMILES
OC[C@@H]1[C@@H](O)[C@@H](F)[C@H](N2C(N=C(N)NC3=O)=C3N=C2)O1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2’-Deoxy-2’-fluoro-alpha-D-arabinoguanosine Related Classifications
HY-154231 Related Classifications
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