3,5-O-Dicaffeoylquinic acid
Based on 1 publication(s) in Google Scholar
3,5-O-Dicaffeoylquinic acid reverses Trimethyltin-induced learning and memory deficits.
For research use only. We do not sell to patients.
- Purity: 99.84%
- CAS No.: 89919-62-0
- Formula: C25H24O12
- Molecular Weight:516.46
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) 3,5-O-Dicaffeoylquinic acid
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
>500 μM
Compound: RLE30
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Inhibition of HDAC in human HeLa cells using Boc-Lys(AC)-AMC as substrate after 24 to 48 hrs by spectrofluorometry
Inhibition of HDAC in human HeLa cells using Boc-Lys(AC)-AMC as substrate after 24 to 48 hrs by spectrofluorometry
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[PMID: 26996372] |
| HT-22 | EC50 |
>100 μM
Compound: 25
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Neuroprotective activity against glutamate-induced cell death in mouse HT-22 cells assessed as increase in cell viability after 24 hrs by EZ-Cytox assay
Neuroprotective activity against glutamate-induced cell death in mouse HT-22 cells assessed as increase in cell viability after 24 hrs by EZ-Cytox assay
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[PMID: 32991171] |
| MT2 | ED50 |
1 μg/mL
Compound: 3,5-DCQA
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Antiviral activity against HIV1 LAI in human MT2 cells assessed as virus-induced cytopathic effect after 72 hrs
Antiviral activity against HIV1 LAI in human MT2 cells assessed as virus-induced cytopathic effect after 72 hrs
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[PMID: 11430019] |
| MT2 | ED50 |
1.9 μM
Compound: 3,5-dicaffeoylquinic acid
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Antiviral activity against HIV1 LAI in MT2 cells assessed as inhibition of virus-induced cytopathic effect
Antiviral activity against HIV1 LAI in MT2 cells assessed as inhibition of virus-induced cytopathic effect
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[PMID: 18674899] |
| MT2 | ED50 |
2 μM
Compound: 3,5-DCQA
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Concentration that inhibits Human Immunodeficiency Virus Type 1 (HIV-1)-induced death of MT-2 cells
Concentration that inhibits Human Immunodeficiency Virus Type 1 (HIV-1)-induced death of MT-2 cells
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[PMID: 9986720] |
| MT2 | IC50 |
1.9 μM
Compound: 8
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Inhibition of HIV1 integrase activity assessed as suppression of viral replication in human MT2 cells
Inhibition of HIV1 integrase activity assessed as suppression of viral replication in human MT2 cells
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[PMID: 27676157] |
Chemical Information
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CAS No. 89919-62-0
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Appearance Solid
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Molecular Weight 516.46
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Formula C25H24O12
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Color White to off-white
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SMILES
OC(C=C1/C=C/C(O[C@H]2[C@H]([C@@H](C[C@@](O)(C2)C(O)=O)OC(/C=C/C3=CC(O)=C(C=C3)O)=O)O)=O)=C(C=C1)O.[(E)].[(E)]
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Chem Pharm Bull
Chromatographic Evaluation and Characterization of Constituents of Sunflower Seed Extract Used as Food Additives. [Abstract]2024;72(1):93-97. PMID: 38233137
Solvent & Solubility
DMSO : 100 mg/mL (193.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.84 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.84 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9363 mL | 9.6813 mL | 19.3626 mL | 48.4065 mL |
| 5 mM | 0.3873 mL | 1.9363 mL | 3.8725 mL | 9.6813 mL | |
| 10 mM | 0.1936 mL | 0.9681 mL | 1.9363 mL | 4.8406 mL | |
| 15 mM | 0.1291 mL | 0.6454 mL | 1.2908 mL | 3.2271 mL | |
| 20 mM | 0.0968 mL | 0.4841 mL | 0.9681 mL | 2.4203 mL | |
| 25 mM | 0.0775 mL | 0.3873 mL | 0.7745 mL | 1.9363 mL | |
| 30 mM | 0.0645 mL | 0.3227 mL | 0.6454 mL | 1.6135 mL | |
| 40 mM | 0.0484 mL | 0.2420 mL | 0.4841 mL | 1.2102 mL | |
| 50 mM | 0.0387 mL | 0.1936 mL | 0.3873 mL | 0.9681 mL | |
| 60 mM | 0.0323 mL | 0.1614 mL | 0.3227 mL | 0.8068 mL | |
| 80 mM | 0.0242 mL | 0.1210 mL | 0.2420 mL | 0.6051 mL | |
| 100 mM | 0.0194 mL | 0.0968 mL | 0.1936 mL | 0.4841 mL |
3,5-O-Dicaffeoylquinic acid Related Classifications
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