3-Hydroxyisobutyric acid sodium
Based on 1 Customer Validation
3-Hydroxyisobutyric acid sodium is an intermediate in the metabolic pathways of L-valine and thymine, and can be found in urine. 3-Hydroxyisobutyric acid sodium is a secreted mediator of endothelial cell fatty acid transport and insulin resistance. 3-Hydroxyisobutyric acid sodium can also inhibit key enzymes of energy metabolism in the cerebral cortex of young rats. The levels of 3-Hydroxyisobutyric acid sodium are closely related to various diseases such as 3-hydroxyisobutyric aciduria, diabetes, and ketoacidosis.
For research use only. We do not sell to patients.
- Purity: 98.76%
- CAS No.: 1219589-99-7
- Formula: C4H7NaO3
- Molecular Weight:126.09
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Biological Activity
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Human Endogenous Metabolite |
3-Hydroxyisobutyric acid (0.1-1 mM) sodium significantly inhibits the activities of respiratory chain complex I-III, total creatine kinase, mitochondrial creatine kinase, and Na+, K+-ATPase in rat cerebral cortex homogenates[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1219589-99-7
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Appearance Solid
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Molecular Weight 126.09
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Formula C4H7NaO3
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Color White to off-white
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SMILES
O=C(O[Na])C(C)CO
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 100 mg/mL (793.08 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Podebrad F, et al. Stereodifferentiation of 3-hydroxyisobutyric- and 3-aminoisobutyric acid in human urine by enantioselective multidimensional capillary gas chromatography-mass spectrometry. Clin Chim Acta. 2000 Feb 25;292(1-2):93-105. [Content Brief]
[2]. Viegas CM, et al. Evidence that 3-hydroxyisobutyric acid inhibits key enzymes of energy metabolism in cerebral cortex of young rats. Int J Dev Neurosci. 2008 May-Jun;26(3-4):293-9. [Content Brief]
[3]. Mardinoglu A, et al. Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes. EBioMedicine. 2018 Jan;27:151-155. [Content Brief]
[4]. Landaas S. Accumulation of 3-hydroxyisobutyric acid, 2-methyl-3-hydroxybutyric acid and 3-hydroxyisovaleric acid in ketoacidosis. Clin Chim Acta. 1975 Oct 15;64(2):143-54. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 7.9308 mL | 39.6542 mL | 79.3084 mL | 198.2711 mL |
| 5 mM | 1.5862 mL | 7.9308 mL | 15.8617 mL | 39.6542 mL | |
| 10 mM | 0.7931 mL | 3.9654 mL | 7.9308 mL | 19.8271 mL | |
| 15 mM | 0.5287 mL | 2.6436 mL | 5.2872 mL | 13.2181 mL | |
| 20 mM | 0.3965 mL | 1.9827 mL | 3.9654 mL | 9.9136 mL | |
| 25 mM | 0.3172 mL | 1.5862 mL | 3.1723 mL | 7.9308 mL | |
| 30 mM | 0.2644 mL | 1.3218 mL | 2.6436 mL | 6.6090 mL | |
| 40 mM | 0.1983 mL | 0.9914 mL | 1.9827 mL | 4.9568 mL | |
| 50 mM | 0.1586 mL | 0.7931 mL | 1.5862 mL | 3.9654 mL | |
| 60 mM | 0.1322 mL | 0.6609 mL | 1.3218 mL | 3.3045 mL | |
| 80 mM | 0.0991 mL | 0.4957 mL | 0.9914 mL | 2.4784 mL | |
| 100 mM | 0.0793 mL | 0.3965 mL | 0.7931 mL | 1.9827 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
3-Hydroxyisobutyric acid sodium Related Classifications
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