2. Metabolic Enzyme/Protease Membrane Transporter/Ion Channel
  3. Endogenous Metabolite ATP Synthase
  4. 3-Hydroxyisobutyric acid sodium

3-Hydroxyisobutyric acid sodium is an intermediate in the metabolic pathways of L-valine and thymine, and can be found in urine. 3-Hydroxyisobutyric acid sodium is a secreted mediator of endothelial cell fatty acid transport and insulin resistance. 3-Hydroxyisobutyric acid sodium can also inhibit key enzymes of energy metabolism in the cerebral cortex of young rats. The levels of 3-Hydroxyisobutyric acid sodium are closely related to various diseases such as 3-hydroxyisobutyric aciduria, diabetes, and ketoacidosis.

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3-Hydroxyisobutyric acid sodium

3-Hydroxyisobutyric acid sodium Chemical Structure

CAS No. : 1219589-99-7

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10 mM * 1 mL in Water
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Based on 1 publication(s) in Google Scholar

Other Forms of 3-Hydroxyisobutyric acid sodium:

3-Hydroxyisobutyric acid sodium Related Antibodies

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Description

3-Hydroxyisobutyric acid sodium is an intermediate in the metabolic pathways of L-valine and thymine, and can be found in urine. 3-Hydroxyisobutyric acid sodium is a secreted mediator of endothelial cell fatty acid transport and insulin resistance. 3-Hydroxyisobutyric acid sodium can also inhibit key enzymes of energy metabolism in the cerebral cortex of young rats. The levels of 3-Hydroxyisobutyric acid sodium are closely related to various diseases such as 3-hydroxyisobutyric aciduria, diabetes, and ketoacidosis[1][2][3][4].

IC50 & Target[1]

Human Endogenous Metabolite

 

In Vitro

3-Hydroxyisobutyric acid (0.1-1 mM) sodium significantly inhibits the activities of respiratory chain complex I-III, total creatine kinase, mitochondrial creatine kinase, and Na+, K+-ATPase in rat cerebral cortex homogenates[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

3-Hydroxyisobutyric acid sodium Related Antibodies
Molecular Weight

126.09

Formula

C4H7NaO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O[Na])C(C)CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (793.08 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.9308 mL 39.6542 mL 79.3084 mL
5 mM 1.5862 mL 7.9308 mL 15.8617 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 7.9308 mL 39.6542 mL 79.3084 mL 198.2711 mL
5 mM 1.5862 mL 7.9308 mL 15.8617 mL 39.6542 mL
10 mM 0.7931 mL 3.9654 mL 7.9308 mL 19.8271 mL
15 mM 0.5287 mL 2.6436 mL 5.2872 mL 13.2181 mL
20 mM 0.3965 mL 1.9827 mL 3.9654 mL 9.9136 mL
25 mM 0.3172 mL 1.5862 mL 3.1723 mL 7.9308 mL
30 mM 0.2644 mL 1.3218 mL 2.6436 mL 6.6090 mL
40 mM 0.1983 mL 0.9914 mL 1.9827 mL 4.9568 mL
50 mM 0.1586 mL 0.7931 mL 1.5862 mL 3.9654 mL
60 mM 0.1322 mL 0.6609 mL 1.3218 mL 3.3045 mL
80 mM 0.0991 mL 0.4957 mL 0.9914 mL 2.4784 mL
100 mM 0.0793 mL 0.3965 mL 0.7931 mL 1.9827 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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3-Hydroxyisobutyric acid sodium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-Hydroxyisobutyric acid1219589-99-7Endogenous MetaboliteATP SynthaseEndogenous metabolitegluconeogenesisL-valinethymine3-hydroxyisobutyric aciduriadiabetesketoacidosisInhibitorinhibitorinhibit

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