4,6-Dioxoheptanoic acid-13C5
Based on 1 Customer Validation
4,6-Dioxoheptanoic acid-13C5 is the 13C labeled 4,6-Dioxoheptanoic acid. 4,6-Dioxoheptanoic acid is a potent inhibitor of heme biosynthesis.
For research use only. We do not sell to patients.
- Purity: 99.8%
- CAS No.: 881835-86-5
- Formula: C213C5H10O4
- Molecular Weight:163.12
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 881835-86-5
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Unlabeled Cas 51568-18-4
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Appearance Solid
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Molecular Weight 163.12
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Formula C213C5H10O4
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Color White to off-white
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SMILES
O=[13C]([13CH2][13C]([13CH3])=O)[13CH2]CC(O)=O
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Synonyms
Succinylacetone-13C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (613.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Ebert PS, et al. Succinylacetone, a potent inhibitor of heme biosynthesis: effect on cell growth, heme contentand delta-aminolevulinic acid dehydratase activity of malignant murine erythroleukemia cells. Biochem Biophys Res Commun. 1979 Jun 27;88(4):1382-90. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.1305 mL | 30.6523 mL | 61.3046 mL | 153.2614 mL |
| 5 mM | 1.2261 mL | 6.1305 mL | 12.2609 mL | 30.6523 mL | |
| 10 mM | 0.6130 mL | 3.0652 mL | 6.1305 mL | 15.3261 mL | |
| 15 mM | 0.4087 mL | 2.0435 mL | 4.0870 mL | 10.2174 mL | |
| 20 mM | 0.3065 mL | 1.5326 mL | 3.0652 mL | 7.6631 mL | |
| 25 mM | 0.2452 mL | 1.2261 mL | 2.4522 mL | 6.1305 mL | |
| 30 mM | 0.2043 mL | 1.0217 mL | 2.0435 mL | 5.1087 mL | |
| 40 mM | 0.1533 mL | 0.7663 mL | 1.5326 mL | 3.8315 mL | |
| 50 mM | 0.1226 mL | 0.6130 mL | 1.2261 mL | 3.0652 mL | |
| 60 mM | 0.1022 mL | 0.5109 mL | 1.0217 mL | 2.5544 mL | |
| 80 mM | 0.0766 mL | 0.3832 mL | 0.7663 mL | 1.9158 mL | |
| 100 mM | 0.0613 mL | 0.3065 mL | 0.6130 mL | 1.5326 mL |
4,6-Dioxoheptanoic acid-13C5 Related Classifications
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