4,6-Dioxoheptanoic acid
Based on 6 publication(s) in Google Scholar
4,6-Dioxoheptanoic acid is a potent inhibitor of heme biosynthesis.
For research use only. We do not sell to patients.
- Purity: 98.81%
- CAS No.: 51568-18-4
- Formula: C7H10O4
- Molecular Weight:158.15
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) 4,6-Dioxoheptanoic acid
More- Signal Transduct Target Ther. 2025 Dec 17;10(1):413. [Abstract]
- Mol Cell. 2023 Jun 15;83(12):2059-2076.e6. [Abstract]
- Pharmacol Res. 2021 Aug:170:105701. [Abstract]
- Genome Biol. 2022 Dec 15;23(1):259. [Abstract]
- The Saudi Journal of Gastroenterology. 2020 Apr.
- bioRxiv. 2024 Jul 6:2024.07.05.602318. [Abstract]
All Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Sf9 | IC50 |
12.7 μM
Compound: 28
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Inhibition of human KDM3A catalytic domain expressed in Sf9 cells methyl lysine peptide substrate by AlphaScreen assay
Inhibition of human KDM3A catalytic domain expressed in Sf9 cells methyl lysine peptide substrate by AlphaScreen assay
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[PMID: 22724510] |
| Sf9 | IC50 |
4.5 μM
Compound: 28
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Inhibition of human KDM5C catalytic domain expressed in Sf9 cells using methyl lysine peptide substrate by AlphaScreen assay
Inhibition of human KDM5C catalytic domain expressed in Sf9 cells using methyl lysine peptide substrate by AlphaScreen assay
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[PMID: 22724510] |
4,6-Dioxoheptanoic acid (Succinylacetone, SA) is examined with regard to its ability to a) inhibit the second enzyme of the heme pathway, δ-aminolevulinic acid (ALA) dehydratase, b) lower the heme concentration, and c) inhibit cell growth of murine erythroleukemia (MEL) cells in culture[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 51568-18-4
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Unlabeled Cas 51568-18-4
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Appearance Solid
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Molecular Weight 158.15
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Formula C7H10O4
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Color White to off-white
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SMILES
CC(=O)CC(=O)CCC(O)=O
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Synonyms
Succinylacetone
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (6)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Disruption of heme homeostasis by nuclear receptor Nur77 induces pyroptosis through granzyme B-dependent GSDMC cleavage. [Abstract]2025 Dec 17;10(1):413. PMID: 41407678 -
Mol Cell
2023 Jun 15;83(12):2059-2076.e6. PMID: 37327776 -
Pharmacol Res
Dihydroartemisinin overcomes the resistance to osimertinib in EGFR-mutant non-small-cell lung cancer. [Abstract]2021 Aug:170:105701. PMID: 34087353 -
Genome Biol
G-quadruplexes sense natural porphyrin metabolites for regulation of gene transcription and chromatin landscapes. [Abstract]2022 Dec 15;23(1):259. PMID: 36522639 -
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bioRxiv
An adaptor for feedback regulation of heme biosynthesis by the mitochondrial protease CLPXP. [Abstract]2024 Jul 6:2024.07.05.602318. PMID: 39005287
Solvent & Solubility
DMSO : 100 mg/mL (632.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 100 mg/mL (632.31 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (15.81 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (15.81 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 6.3231 mL | 31.6156 mL | 63.2311 mL | 158.0778 mL |
| 5 mM | 1.2646 mL | 6.3231 mL | 12.6462 mL | 31.6156 mL | |
| 10 mM | 0.6323 mL | 3.1616 mL | 6.3231 mL | 15.8078 mL | |
| 15 mM | 0.4215 mL | 2.1077 mL | 4.2154 mL | 10.5385 mL | |
| 20 mM | 0.3162 mL | 1.5808 mL | 3.1616 mL | 7.9039 mL | |
| 25 mM | 0.2529 mL | 1.2646 mL | 2.5292 mL | 6.3231 mL | |
| 30 mM | 0.2108 mL | 1.0539 mL | 2.1077 mL | 5.2693 mL | |
| 40 mM | 0.1581 mL | 0.7904 mL | 1.5808 mL | 3.9519 mL | |
| 50 mM | 0.1265 mL | 0.6323 mL | 1.2646 mL | 3.1616 mL | |
| 60 mM | 0.1054 mL | 0.5269 mL | 1.0539 mL | 2.6346 mL | |
| 80 mM | 0.0790 mL | 0.3952 mL | 0.7904 mL | 1.9760 mL | |
| 100 mM | 0.0632 mL | 0.3162 mL | 0.6323 mL | 1.5808 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
4,6-Dioxoheptanoic acid Related Classifications
HY-W010184 Related Classifications
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