4-(Trifluoromethoxy)benzoic acid-d₄ 

4-(Trifluoromethoxy)benzoic acid-d₄ is the deuterium labeled 4-(Trifluoromethoxy)benzoic acid^[1].

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

210.14

C₈HD₄F₃O₃

2741881-05-8

330-12-1

Solid

White to off-white

FC(F)(F)OC1=C([2H])C([2H])=C(C(O)=O)C([2H])=C1[2H]

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]