1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. 5-ALA benzyl ester hydrochloride

5-ALA benzyl ester hydrochloride (Synonyms: Benzyl-ALA hydrochloride)

Cat. No.: HY-133100 Purity: 99.76%
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5-ALA benzyl ester hydrochloride (Benzyl-ALA hydrochloride) is a protoporphyrin precursor used as a photodetection agent. 5-ALA benzyl ester hydrochloride induces protoporphyrin IX (PPIX) accumulation in colon carcinoma cell lines.

For research use only. We do not sell to patients.

5-ALA benzyl ester hydrochloride Chemical Structure

5-ALA benzyl ester hydrochloride Chemical Structure

CAS No. : 163271-32-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 72 In-stock
Estimated Time of Arrival: December 31
10 mg USD 65 In-stock
Estimated Time of Arrival: December 31
25 mg USD 130 In-stock
Estimated Time of Arrival: December 31
50 mg USD 220 In-stock
Estimated Time of Arrival: December 31
100 mg USD 370 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

5-ALA benzyl ester hydrochloride (Benzyl-ALA hydrochloride) is a protoporphyrin precursor used as a photodetection agent. 5-ALA benzyl ester hydrochloride induces protoporphyrin IX (PPIX) accumulation in colon carcinoma cell lines[1][2].

IC50 & Target[1]

Human Endogenous Metabolite

 

In Vitro

5-ALA benzyl ester hydrochloride (Benzyl-ALA hydrochloride) (0.6-0.12 mM; 3 h) induces protoporphyrin IX (PPIX) accumulation in colon carcinoma cell lines SW480[2].

In Vivo

Reducing the dose of 5-ALA benzyl ester hydrochloride (31 mg/kg; i.v. ; 1 hours) results in a dose-dependent reduction in tumour porphyrin levels[3].

Animal Model: Female CBA/Gy mouse (CaNT tumour model)[3]
Dosage: 31 mg/kg
Administration: i.v. ; 1 hours
Result: Reducing the dose of 5-ALA benzyl ester hydrochloride resulted in a dose-dependent reduction in the concentration of porphyrins accumulating in the CaNT tumour.
Molecular Weight

257.71

Formula

C₁₂H₁₆ClNO₃

CAS No.

163271-32-7

SMILES

O=C(OCC1=CC=CC=C1)CCC(CN)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (970.08 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8803 mL 19.4017 mL 38.8033 mL
5 mM 0.7761 mL 3.8803 mL 7.7607 mL
10 mM 0.3880 mL 1.9402 mL 3.8803 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (8.07 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (8.07 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (8.07 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

5-ALA benzyl esterBenzyl-ALAEndogenous MetaboliteprotoporphyrinphotodetectionaccumulationcoloncarcinomaSW480Inhibitorinhibitorinhibit

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Product name:
5-ALA benzyl ester hydrochloride
Cat. No.:
HY-133100
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