1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. 5-ALA benzyl ester hydrochloride

5-ALA benzyl ester hydrochloride (Synonyms: Benzyl-ALA hydrochloride)

Cat. No.: HY-133100
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5-ALA benzyl ester hydrochloride (Benzyl-ALA hydrochloride) is a protoporphyrin precursor used as a photodetection agent. 5-ALA benzyl ester hydrochloride induces protoporphyrin IX (PPIX) accumulation in colon carcinoma cell lines.

For research use only. We do not sell to patients.

5-ALA benzyl ester hydrochloride Chemical Structure

5-ALA benzyl ester hydrochloride Chemical Structure

CAS No. : 163271-32-7

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10 mM * 1 mL in DMSO USD 72 In-stock
Estimated Time of Arrival: December 31
10 mg USD 65 In-stock
Estimated Time of Arrival: December 31
25 mg USD 130 In-stock
Estimated Time of Arrival: December 31
50 mg USD 220 In-stock
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100 mg USD 370 In-stock
Estimated Time of Arrival: December 31
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Description

5-ALA benzyl ester hydrochloride (Benzyl-ALA hydrochloride) is a protoporphyrin precursor used as a photodetection agent. 5-ALA benzyl ester hydrochloride induces protoporphyrin IX (PPIX) accumulation in colon carcinoma cell lines[1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

5-ALA benzyl ester hydrochloride (Benzyl-ALA hydrochloride) (0.6-0.12 mM; 3 h) induces protoporphyrin IX (PPIX) accumulation in colon carcinoma cell lines SW480[2].

In Vivo

Reducing the dose of 5-ALA benzyl ester hydrochloride (31 mg/kg; i.v. ; 1 hours) results in a dose-dependent reduction in tumour porphyrin levels[3].

Animal Model: Female CBA/Gy mouse (CaNT tumour model)[3]
Dosage: 31 mg/kg
Administration: i.v. ; 1 hours
Result: Reducing the dose of 5-ALA benzyl ester hydrochloride resulted in a dose-dependent reduction in the concentration of porphyrins accumulating in the CaNT tumour.
Molecular Weight

257.71

Formula

C₁₂H₁₆ClNO₃

CAS No.

163271-32-7

SMILES

O=C(OCC1=CC=CC=C1)CCC(CN)=O.[H]Cl

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

5-ALA benzyl esterBenzyl-ALAEndogenous MetaboliteprotoporphyrinphotodetectionaccumulationcoloncarcinomaSW480Inhibitorinhibitorinhibit

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5-ALA benzyl ester hydrochloride
Cat. No.:
HY-133100
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