1. Flavonoids
  2. 7,4'-Di-O-methylapigenin

7,4'-Di-O-methylapigenin (Synonyms: 4',7-Dimethoxy-5-Hydroxyflavone)

Cat. No.: HY-N2144 Purity: 99.09%
Handling Instructions

The compound 7,4'-Di-O-methylapigenin may be partly responsible for the reported antifungal activity of C.

For research use only. We do not sell to patients.

7,4'-Di-O-methylapigenin Chemical Structure

7,4'-Di-O-methylapigenin Chemical Structure

CAS No. : 5128-44-9

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Solution
10 mM * 1 mL in DMSO USD 157 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 157 In-stock
Estimated Time of Arrival: December 31
Solid
2 mg USD 96 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
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Description

The compound 7,4'-Di-O-methylapigenin may be partly responsible for the reported antifungal activity of C. zeyheri, and may serve as a potential source of lead compounds that can be developed as antifungal phytomedicines.And it also showed inhibition of the drug efflux pumps (with IC50 = 51.64 μg/ml). IC50:51.64 μg/ml(Candida albicans drug efflux pumps)[2] In vitro: The isolated 7,4'-Di-O-methylapigenin was further investigated for its inhibitory activity on ABC drug efflux pumps in C. albicans by monitoring an increase in ciprofloxacin, assessing the level of its accumulation, in response to reserpine. There was a higher accumulation of ciprofloxacin in Candida cells in the presence of 7,4'-Di-O-methylapigenin than with reserpine. The compound 7,4'-Di-O-methylapigenine demonstrated the activity in a dose-dependent manner with IC50 value of 51.64 μg/ml. These results support those obtained from synergism assays where by the underlying synergistic antifungal mechanisms could be due to blockage of ABC efflux pumps and increasing the susceptibility of Candida to miconazole.[2] In vivo: In searching for natural products as potential anti-inflammatory agents, 7,4'-Di-O-methylapigenin wasn't evaluated in vivo for its ability to inhibit acute inflammation.[1]

Molecular Weight

298.29

Formula

C17H14O5

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (16.76 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (ultrasonic;warming) (insoluble)

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3524 mL 16.7622 mL 33.5244 mL
5 mM 0.6705 mL 3.3524 mL 6.7049 mL
10 mM 0.3352 mL 1.6762 mL 3.3524 mL
*Please refer to the solubility information to select the appropriate solvent.
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Product Name:
7,4'-Di-O-methylapigenin
Cat. No.:
HY-N2144
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