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Cat. No.: HY-187140

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7-Carboxyheptyl)triphenylphosphonium bromide

(7-Carboxyheptyl) triphenylphosphonium bromide (Compound 15) is a triphenylphosphonium cationic carboxylic acid and serves as a synthetic precursor for the preparation of mitochondria-targeted antibiotic conjugates.

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CAS No.: 52956-93-1
Formule: C₂₆H₃₀BrO₂P
Masse moléculaire:485.40

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Please store the product under the recommended conditions in the Certificate of Analysis.

7-Carboxyheptyl)triphenylphosphonium bromide Chemical Structure

CAS No.: 52956-93-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
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- Cellular Effect
- In Vitro
Chemical Information
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Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	20 μM Compound: 13	Antiproliferative activity against human A-375 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human A-375 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay	[PMID: 35818137]
A549	IC₅₀	20 μM Compound: 13	Antiproliferative activity against human A549 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay	[PMID: 35818137]
L02	IC₅₀	64 μg/mL Compound: 14	Cytotoxicity against human L02 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay Cytotoxicity against human L02 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay	[PMID: 38096652]
MCF7	IC₅₀	20 μM Compound: 13	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay	[PMID: 35818137]
MDA-MB-231	IC₅₀	20 μM Compound: 13	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay	[PMID: 35818137]

In Vitro

The terminal carboxyl group of (7-carboxyheptyl) triphenylphosphonium bromide is used for conjugation to achieve mitochondrial delivery.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 52956-93-1
Masse moléculaire 485.40
Formule C₂₆H₃₀BrO₂P
SMILES

[Br-].O=C(O)CCCCCCC[P+](C=1C=CC=CC1)(C=2C=CC=CC2)C=3C=CC=CC3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Cochrane EJ, et al. Impact of Mitochondrial Targeting Antibiotics on Mitochondrial Function and Proliferation of Cancer Cells. ACS medicinal chemistry letters. 2021 Apr 08;12(4):579-584.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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7-Carboxyheptyl)triphenylphosphonium bromide

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7-Carboxyheptyl)triphenylphosphonium bromide

Activité biologique

Description

Cellular Effect

In Vitro

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

7-Carboxyheptyl)triphenylphosphonium bromide Related Classifications

HY-187140 Related Classifications

Bioz

Keywords

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