7-Hydroxymethyl-10,11-MDCPT-d₅ 

7-Hydroxymethyl-10,11-MDCPT-d₅ is deuterium labeled 7-Hydroxymethyl-10,11-MDCPT, which is a is a payload that can be used for ADC synthesis^[1].

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

427.42

C₂₂H₁₃D₅N₂O₇

428816-69-7

Solid

Light yellow to yellow

OCC1=C2C(C(N3C2)=CC([C@]4(C([2H])(C([2H])([2H])[2H])[2H])O)=C(C3=O)COC4=O)=NC5=CC6=C(C=C51)OCO6

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Cai JQ, Human anti-human HER3 antibodies and ADCs or drug conjugates for therapy, prevention and diagnosis of cancer or infection. 2023. WO2023143263

  [2]. Wadkins RM, et al. Hydrophilic camptothecin analogs that form extremely stable cleavable complexes with DNA and topoisomerase I. Cancer Res. 2004 Sep 15;64(18):6679-83.  [Content Brief]