428816-69-7
428816-69-7
Chemical Structure
7-Hydroxymethyl-10,11-MDCPT
- CAS No.: 428816-69-7
- Formula:C22H18N2O7
- Molecular Weight:422.39
InChIKey: UYOXKDDEJDVQSN-QFIPXVFZSA-N
SMILES: OCC1=C2C(C(N3C2)=CC([C@](O)(C(OC4)=O)CC)=C4C3=O)=NC5=CC(OCO6)=C6C=C51
Biological Activity: 7-Hydroxymethyl-10,11-MDCPT is a hydrophilic camptothecin analog. 7-Hydroxymethyl-10,11-MDCPT is a payload that can be used for ADC synthesis[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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7-Hydroxymethyl-10,11-MDCPT | 97.53% | 7-Hydroxymethyl-10,11-MDCPT is a hydrophilic camptothecin analog. 7-Hydroxymethyl-10,11-MDCPT is a payload that can be used for ADC synthesis. | ||||||||||||||||||||
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7-Hydroxymethyl-10,11-MDCPT-d5 | 98.03% | 7-Hydroxymethyl-10,11-MDCPT-d5 is deuterium labeled 7-Hydroxymethyl-10,11-MDCPT, which is a is a payload that can be used for ADC synthesis. | ||||||||||||||||||||
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References
- [1]. Cai JQ, Human anti-human HER3 antibodies and ADCs or drug conjugates for therapy, prevention and diagnosis of cancer or infection. 2023. WO2023143263
- [2]. Wadkins RM, et al. Hydrophilic camptothecin analogs that form extremely stable cleavable complexes with DNA and topoisomerase I. Cancer Res. 2004;64(18):6679-6683. [Content Brief]
