D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt  (Synonyms: Inositol 1,4,5-trisphosphate hexapotassium salt; Ins(1,4,5)-P3 hexapotassium salt)

D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt is the hexapotassium salt of D-myo-Inositol 1,4,5-trisphosphate (1,4,5-IP3), which is a second messenger that stimulates the discharge of calcium from the endoplasmic reticulum.

Second messenger D-myo-Inositol 1,4,5-trisphosphate (1,4,5-IP3) is served as an inositol phosphate derivative. The dissociation constant (K_D) for Pr55^Gag complexed with D-myo-Inositol 1,4,5-trisphosphate (an inositol with divalent phosphate groups and devoid of lipid groups) is 2170 μM. The binding affinities of D-myo-Inositol 1,4,5-trisphosphate (K_D=568 μM) and 1,3,4,5-IP4 (K_D=526 μM) for matrix (MA) are almost identical^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

648.64

C₆H₉K₆O₁₅P₃

103476-24-0

Solid

White to off-white

O[C@H]1[C@@H](OP(O[K])(O[K])=O)[C@H](O)[C@@H](OP(O[K])(O[K])=O)[C@H](OP(O[K])(O[K])=O)[C@H]1O

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Anraku K, et al. Highly sensitive analysis of the interaction between HIV-1 Gag and phosphoinositide derivatives based on surface plasmon resonance. Biochemistry. 2010 Jun 29;49(25):5109-16.  [Content Brief]