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Eurycomanone (Synonyms: Pasakbumin A)

製品番号: HY-N5012 純度: 99.48%
取扱説明書

Eurycomanone could increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis.

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Eurycomanone 構造式

Eurycomanone 構造式

CAS 番号 : 84633-29-4

容量 価格(税別) 在庫状況 数量
10 mM * 1 mL in DMSO USD 162 在庫あり
Estimated Time of Arrival: December 31
1 mg USD 80 在庫あり
Estimated Time of Arrival: December 31
5 mg USD 180 在庫あり
Estimated Time of Arrival: December 31
10 mg USD 280 在庫あり
Estimated Time of Arrival: December 31
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

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製品説明

Eurycomanone could increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis.

体外実験

Eurycomanone (EN) significantly increased testosterone production dose-dependently at 0.1, 1.0 and 10.0 μM, but the two lower doses when combined with 3-isobutyl-1-methylxanthine (IBMX), the phosphodiesterase inhibitor were not significantly higher than EN or IBMX alone, except at a higher concentration. The molecular docking studies indicated EN and IBMX were binding at different sites of the enzyme. EN has no reversal of inhibition by aminoglutethimide, ketoconazole or nifedipine at the respective steroid oogenesis enzyme. The quassinoid was also non-responsive to the inhibition of oestrogen receptor by tamoxifen, but displayed improved for mestane inhibition of aromatase in reducing oestrogen production. The molecular docking studies further supported that EN and formestane bound to aromatase with similar orientations and free energy binding values[1].

分子量

408.40

分子式

C₂₀H₂₄O₉

CAS 番号

84633-29-4

SMILES
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 16.67 mg/mL (40.82 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4486 mL 12.2429 mL 24.4858 mL
5 mM 0.4897 mL 2.4486 mL 4.8972 mL
10 mM 0.2449 mL 1.2243 mL 2.4486 mL
*Please refer to the solubility information to select the appropriate solvent.
体内:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.83 mg/mL (2.03 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.83 mg/mL (2.03 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.83 mg/mL (2.03 mM); Clear solution

*All of the co-solvents are provided by MCE.
参考文献
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Keywords:

EurycomanonePasakbumin AOthersInhibitorinhibitorinhibit

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製品名:
Eurycomanone
製品番号:
HY-N5012
数量:
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