KP136
KP136 (AL136) is an orally effective antiallergic agent. The IC50 is 76.1 μg/mL for histamine release and 63 ug/mL for degranulation.
For research use only. We do not sell to patients.
- CAS No.: 76239-32-2
- Formula: C16H18N4O3
- Molecular Weight:314.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- Purity & Documentation
- References
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Help & FAQs
All Histamine Receptor Isoforms
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Biological Activity
Description
IC50 & Target
Histamine release[1]
In Vitro
KP136 (0.01 μg/mL) inhibits this histamine release and degranulation in a dose-dependent manner, confirming that it is an inhibitor of mast cell activation. The IC50 is 76.1 μg/mL for histamine release and 63 ug/mL for degranulation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 76239-32-2
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Molecular Weight 314.34
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Formula C16H18N4O3
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SMILES
O=C1C(C2=NNN=N2)=CC3=CC=CC(OCCCCCC)=C3O1
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Synonyms
AL136
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
Animal Administration[1]
Pigs[1]
The trachea is taken from male guinea pigs, weighing 500-590 g, that are sacrificed by bleeding and then cut into 1.5 mm wide to make tracheal rings. Five specimens are tied at cartilage sites crossing each smooth muscle layer. This preparation is incubated in Tyrode's solution at 37°C, which is bubbled with 95% O2/5% CO2. The tension change of the tracheal muscle preparation is recorded through an isotonic transducer. C4C and KP136 in 0.5% KHCO3 or isoproterenol in saline is added cumulatively to the Tyrode's solution at a 1/200 volume. Relaxation percentage is calculated from the maximum relaxation value (100%) produces by re placement of the bathing medium with Tyrode's solution containing no CaCl2.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KP136 Related Classifications
HY-U00168 Related Classifications
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