1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor
  3. LY2940094 tartrate

LY2940094 tartrate (Synonyms: BTRX-246040 tartrate)

Cat. No.: HY-114452A
Handling Instructions

LY2940094 (BTRX-246040) tartrate is a potent, brain penetrant, selective and orally available N/OFQ peptide (NOP) receptor antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). LY2940094 tartrate reduces Ethanol self-administration and Ethanol seeking in animal models.

For research use only. We do not sell to patients.

LY2940094 tartrate Chemical Structure

LY2940094 tartrate Chemical Structure

CAS No. : 1307245-87-9

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Description

LY2940094 (BTRX-246040) tartrate is a potent, brain penetrant, selective and orally available N/OFQ peptide (NOP) receptor antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). LY2940094 tartrate reduces Ethanol self-administration and Ethanol seeking in animal models[1].

IC50 & Target

Ki: 0.105 nM (NOP receptor)[1]
Kb: 0.166 nM (NOP receptor)[1]

In Vivo

LY2940094 (3, 10, or 30 mg/kg; orally daily for 4 days) dose-dependently reduces homecage ethanol self-administration in Indiana Alcohol-Preferring (P) and Marchigian Sardinian Alcohol-Preferring (msP) rats, without affecting food/water intake or locomotor activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Alcohol-Preferring (P) rats (250-320 g); Male Marchigian Sardinian Alcohol-Preferring (msP) rats (400-450 g)[1]
Dosage: 3, 10, or 30 mg/kg
Administration: P.o.; daily for 4 days
Result: Reduced homecage ethanol self-administration.
Clinical Trial
Molecular Weight

631.05

Formula

C₂₆H₂₉ClF₂N₄O₈S

CAS No.
SMILES

OCC1=CC=CN=C1N2N=C(C)C(CN3CCC4(C5=C(C=C(Cl)S5)C(F)(F)CO4)CC3)=C2.O=C(O)[[email protected]](O)[[email protected]@H](O)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

LY2940094BTRX-246040LY 2940094LY-2940094BTRX246040BTRX 246040Opioid Receptororally ethanolself-administrationpenetratebrainmajordepressivedisorderInhibitorinhibitorinhibit

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Product Name:
LY2940094 tartrate
Cat. No.:
HY-114452A
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