1. Anti-infection
  2. Bacterial
  3. Lenampicillin hydrochloride

Lenampicillin hydrochloride (Synonyms: KBT 1585 hydrochloride)

Cat. No.: HY-100500 Purity: >99.0%
Handling Instructions

Lenampicillin hydrochloride (KBT 1585 hydrochloride) is an orally active prodrug of Ampicillin and is an effective beta-lactam antibacterial agent that inhibits bacterial penicillin-binding proteins (transpeptidase). Lenampicillin hydrochloride has improved absorption and decreased side effects compares to Ampicillin and is applied in the investigation of the suppurative skin and soft tissue infection .

For research use only. We do not sell to patients.

Lenampicillin hydrochloride Chemical Structure

Lenampicillin hydrochloride Chemical Structure

CAS No. : 80734-02-7

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10 mM * 1  mL in DMSO USD 184 In-stock
Estimated Time of Arrival: December 31
2 mg USD 96 In-stock
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5 mg USD 168 In-stock
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10 mg USD 264 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Lenampicillin hydrochloride (KBT 1585 hydrochloride) is an orally active prodrug of Ampicillin and is an effective beta-lactam antibacterial agent that inhibits bacterial penicillin-binding proteins (transpeptidase). Lenampicillin hydrochloride has improved absorption and decreased side effects compares to Ampicillin and is applied in the investigation of the suppurative skin and soft tissue infection [1] [2] [3].

IC50 & Target

IC50: bacterial penicillin-binding proteins (transpeptidase)

In Vivo

Lenampicillin hydrochloride (KBT-1585) (oral adminstration; 0-1000 mg/kg) does not lead to death in dogs, and maximum dose of in this acute toxicity study is recorded because of causing emesis[2].
Lenampicillin hydrochloride (LAPC) are identified for it main metabolites in rat and dogs. The main metabolite in peripheral plasma is 2,3-butanediol in rats and dog, On the other hand, high levels of acetoin is found in portal plasma for early period after dosing of LAPC. These results shows that the biotransformation of promoiety in LAPC to acetoin carried out mainly in intestinal tissues, but acetoin is converted to 2,3-butanediol in liver[3].

Molecular Weight

497.95

Formula

C₂₁H₂₄ClN₃O₇S

CAS No.

80734-02-7

SMILES

O=C([[email protected]@H]1N(C2=O)[[email protected]]([[email protected]@H]2NC([[email protected]@H](C3=CC=CC=C3)N)=O)([H])SC1(C)C)OCC(OC4=O)=C(O4)C.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

References

Purity: >99.0%

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Keywords:

LenampicillinKBT 1585KBT1585KBT-1585BacterialantibacterialBeta-lactamampicillinsuppurativeinfectiontranspeptidaseInhibitorinhibitorinhibit

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Product name:
Lenampicillin hydrochloride
Cat. No.:
HY-100500
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