1. GPCR/G Protein
  2. Motilin Receptor
  3. Motilin (26-47), human, porcine

Motilin (26-47), human, porcine 

Cat. No.: HY-P1037 Purity: 95.82%
Handling Instructions

Motilin (26-47), human, porcine is an endogenous motilin receptor ligand with Ki and EC50 of 2.3 nM and 0.3 nM in a Chinese hamster ovary cell line.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Motilin (26-47), human, porcine Chemical Structure

Motilin (26-47), human, porcine Chemical Structure

CAS No. : 52906-92-0

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500 μg USD 168 In-stock
Estimated Time of Arrival: December 31
1 mg USD 276 In-stock
Estimated Time of Arrival: December 31
5 mg USD 1188 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Motilin (26-47), human, porcine is an endogenous motilin receptor ligand with Ki and EC50 of 2.3 nM and 0.3 nM in a Chinese hamster ovary cell line.

IC50 & Target

EC50: 0.3 nM (motilin receptor, Chinese hamster ovary cell)[1]
Ki: 2.3 nM (motilin receptor, Chinese hamster ovary cell)[1]

In Vitro

[Bpa1,Ile13]motilin is a full agonist at the motilin receptor that increases intracellular calcium in a concentration-dependent manner (EC50 = 1.5 ± 0.4 nM)[1]. Motilin binds with high affinity (IC50 0.7± 0.2 nM) to receptors on smooth muscle cells. Motilin selectively activates G(q) and G(13), stimulates G alpha(q)-dependent phosphoinositide (PI) hydrolysis and 1,4,5-trisphosphate (IP(3))-dependent Ca2+ release, and increases cytosolic free Ca2+. Motilin induces a biphasic, concentration-dependent contraction (EC50 = 1.0 +/- 0.2 nM), consisting of an initial peak followed by a sustained contraction[2].

Molecular Weight

2699.07

Formula

C₁₂₀H₁₈₈N₃₄O₃₅S

CAS No.

52906-92-0

Sequence

Phe-Val-Pro-Ile-Phe-Thr-Tyr-Gly-Glu-Leu-Gln-Arg-Met-Gln-Glu-Lys-Glu-Arg-Asn-Lys-Gly-Gln

Sequence Shortening

FVPIFTYGELQRMQEKERNKGQ

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

Motilin (26-47), human, porcineMotilin ReceptorMLNRInhibitorinhibitorinhibit

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Motilin (26-47), human, porcine
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