2. Signaling Pathways
  3. Neuronal Signaling
  4. Cholinesterase (ChE)

Cholinesterase (ChE)

Cholinesterase (ChE)

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Cholinesterase (ChE) is a family of enzymes present in the central nervous system, particularly in nervous tissue, muscle and red cells, which catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. It is one of many important enzymes needed for the proper functioning of the nervous systems of humans.

There are two types: acetylcholinesterase (AChE, acetylcholine hydrolase) and butyrylcholinesterase (BChE, acylcholine acylhydrolase), also known as nonspecific cholinesterase or pseudocholinesterase. AChE is primarily found in the blood on red blood cell membranes, in neuromuscular junctions, and in neural synapses, while BChE is produced in the liver and found primarily in plasma. The difference between the two types of cholinesterase is their relative preferences for substrates: AChE hydrolyzes acetylcholine faster while BChE hydrolyzes butyrylcholine faster.

Cholinesterase (ChE) Isoform Specific Products:

Cholinesterase (ChE) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-155086
    hAChE-IN-4
    		Inhibitor
    hAChE-IN-4 (Compd 5d) is a potent, blood-brain barrier-permeable hAChE inhibitor with IC50 of 0.25 μM. hAChE-IN-4 can be used in Alzheimer's disease research.
    hAChE-IN-4
  • HY-146399
    AChE/BChE-IN-9
    		Inhibitor
    AChE/BChE-IN-9 (Compound 7a) is a potent, orally active AChE and BChE inhibitor with IC50 values of 5.74 μM and 14.05 μM against hAChE and eqBChE, respectively. AChE/BChE-IN-9 is also an efficacious antioxidant with an IC50 of 57.35 μM. AChE/BChE-IN-9 is able to chelate iron and modulates aggregation of amyloid β1-42. AChE-IN-16 can cross the BBB.
    AChE/BChE-IN-9
  • HY-170417
    hAChE/hBuChE/GSK-3β-IN-1
    		Inhibitor
    hAChE/hBuChE/GSK-3β-IN-1 (Compound 6c) is a BBB-penetrable and multi-target anti-Alzheimer's disease compound. hAChE/hBuChE/GSK-3β-IN-1 is the inhibitors of hAChE (IC50: 28.88 nM), hBuChE (IC50: 131.90 nM) and GSK-3β (IC50: 51.42 nM). hAChE/hBuChE/GSK-3β-IN-1 is the tau and Aβ protein aggregation inhibitors.
    hAChE/hBuChE/GSK-3β-IN-1
  • HY-N12622
    AChE-IN-58
    		Inhibitor
    AChE-IN-58 (Compound 3) is an acetylcholinesterase (AChE) inhibitor. AChE-IN-58 can extend the mean lifespan, delay the Aβ1-42-induced paralysis, enhanc the locomotion, and alleviate glutamic acid (Glu)-induced neurotoxicity of CL4176 worms.
    AChE-IN-58
  • HY-152112
    AChE/BChE/MAO-B-IN-2
    		Inhibitor
    AChE/BChE/MAO-B-IN-2 is a potent AChE, BChE, and MAO-B enzymes inhibitor with IC50 values of 48.2 nM, 83.9 nM, and 31.2 nM, respectively. AChE/BChE/MAO-B-IN-2 has significant antioxidant activity, and can be used for Parkinson’s disease research.
    AChE/BChE/MAO-B-IN-2
  • HY-180382
    Trimethidinium methosulfate
    		Inhibitor
    Trimethidinium methosulfate is an orally active ganglionic blocker with central antihypertensive activity. Trimethidinium methosulfate inhibits the conduction of sympathetic ganglia and reduces vascular contraction. Trimethidinium methosulfate acts on the cerebrovascular motor center and lowers peripheral vascular resistance. Trimethidinium methosulfate has cholinergic nerve inhibitory side effects, but they are relatively mild. Trimethidinium methosulfate can be used in hypertension research.
    Trimethidinium methosulfate
  • HY-172782
    BuChE-IN-20
    		Inhibitor
    BuChE-IN-20 is a selective butyrylcholinesterase (hBuChE) inhibitor (IC50 = 0.13 μM) with BBB permeability. BuChE-IN-20 is a L-Tryptophan derivative. BuChE-IN-20 possesses neuroprotective properties by inhibiting the production of nitric oxide (NO) and lowering the levels of ROS. BuChE-IN-20 is proficient in inhibiting the self-aggregation of amyloid-beta (Aβ) peptides. BuChE-IN-20 can be used in research for Alzheimer’s disease.
    BuChE-IN-20
  • HY-N12423
    Bis-(-)-8-demethylmaritidine
    		Inhibitor
    Bis-(-)-8-demethylmaritidine, a natural alkaloid, is a potent acetylcholinesterase (AChE) inhibitor. Bis-(-)-8-demethylmaritidine can be used for Alzheimer's disease research.
    Bis-(-)-8-demethylmaritidine
  • HY-19085
    KW-6055
    		Activator
    KW-6055 is a benzylpyridine derivative with anti-amnesic effects. KW-6055 can increase the level of ACh in the brain cholinergic system and stimulate cholinergic neurons.
    KW-6055
  • HY-161142
    Carbonic anhydrase/AChE-IN-1
    		Inhibitor
    Carbonic anhydrase/AChE-IN-1 (compound 16) is a carbonic anhydrase and AChE inhibitor with Kis of 24.42 nM, 19.95 nM, and 5.07 nM for hCA I, hCA II, and AChE, respectively.
    Carbonic anhydrase/AChE-IN-1
  • HY-148412C
    Monarsen sodium scrambled negative control
    		Inhibitor
    Monarsen sodium scrambled negative control is the sequence scrambled negative control of Monarsen sodium.
    Monarsen sodium scrambled negative control
  • HY-151370
    AChE-IN-26
    		99.73%
    AChE-IN-26 (compound 4a) is an AChE (acetylcholinesterase) inhibitor with an IC50 value of 0.42 μM. AChE-IN-26 can be used for the research of Alzheimer’s disease.
    AChE-IN-26
  • HY-B0830R
    Isoprocarb (Standard)
    		Inhibitor
    Isoprocarb (Standard) is the analytical standard of Isoprocarb. This product is intended for research and analytical applications. Isoprocarb is carbamate insecticide that widely used to control rice paddy lice and leafhopper. Isoprocarb is also an AChE inhibitor.
    Isoprocarb (Standard)
  • HY-B1277AS
    Trihexyphenidyl-d5
    Trihexyphenidyl-d5 is deuterium labeled Trihexyphenidyl (HY-B1277A). Trihexyphenidyl is a selective and orally active M1 muscarinic receptor antagonist with an IC50 of 3.7 nM for rat cerebral cortex M1 muscarinic receptors. Trihexyphenidyl modulates cholinergic activity, countering acetylcholine supersensitivity in neural pathways. Trihexyphenidyl improves movement disorder, inhibits McN-A-343 (HY-107648)-induced pressor responses, vagally-induced bradycardia and vasodilatation. Trihexyphenidyl can be used for the research of Parkinson's disease..
    Trihexyphenidyl-d<sub>5</sub>
  • HY-N0859R
    Schisanhenol (Standard)
    		Inhibitor
    Schisanhenol (Standard) (Schizanhenol (Standard)) is the analytical standard of Schisanhenol (HY-N0859). This product is intended for research and analytical applications. Schisanhenol, a lignan, is an orally active antioxidant. Schisanhenol reduces AChE activity, increases SIRT1 and PGC-1α expression, and decreases phosphorylated Tau (Ser 396) levels. Schisanhenol increases SOD and glutathione peroxidase activity, decreases malondialdehyde (MDA) content, and inhibits UGT2B7 activitY. Schisanhenol attenuates ox-LDL-induced apoptosis, intracellular reactive oxygen species generation, and cytotoxicity in endothelial cells. Schisanhenol inhibits LDL oxidation, brain mitochondrial and membrane peroxidative damage, and brain mitochondrial swelling and disintegration. Schisanhenol can be used for the research of Alzheimer’s disease, atherosclerosis, brain ischemia, and age-related brain deterioration.
    Schisanhenol (Standard)
  • HY-119492
    Phenchlobenpyrrone
    		Inhibitor
    Phenchlobenpyrrone is a highly selective neuronal calcium antagonist that crosses the blood-brain barrier. Phenchlobenpyrrone mildly inhibits AChE activity. Phenchlobenpyrrone inhibits Aβ aggregation and promotes the clearance of Aβ oligomers. Phenchlobenpyrrone reduces abnormal phosphorylation of Tau protein. Phenchlobenpyrrone may be used in research on Alzheimer's disease.
    Phenchlobenpyrrone
  • HY-B1315S
    Carbaryl-d3
    		Inhibitor
    Carbaryl-d3 is the deuterium labeled Carbaryl (HY-B1315). Carbaryl is the inhibitor for acetylcholinesterase that inhibits the degradation of acetylcholine in the synaptic cleft, leads to the accumulation of acetylcholine and causes neurotoxicity. Carbaryl can be used as an insecticide. X
    Carbaryl-d<sub>3</sub>
  • HY-181811
    PJ17
    		Inhibitor
    PJ17 is a potent dual-target inhibitor of AChE and GSK-3β, with IC50 values of 8.84 μM and 4.19 μM, respectively. PJ17 shows no significant neurotoxic effect in primary cerebellar granule neuron cultures. PJ17 serves as a template for the design of multitarget drugs. PJ17 can be used for the research of Alzheimer's disease.
    PJ17
  • HY-156358
    AChE-IN-43
    		Inhibitor
    AChE-IN-43 is a potent and selective inhibitor of AChE with a Ki of 0.41 μM. AChE-IN-43 can be used in study neurological disease.
    AChE-IN-43
  • HY-181119
    AChE-IN-106
    		Inhibitor
    AChE-IN-106 is an AChE inhibitor. AChE-IN-106 shows no obvious cytotoxicity at low concentrations. AChE-IN-106 can be used for the research of Alzheimer's disease.
    AChE-IN-106
Cat. No. Product Name / Synonyms Application Reactivity
Cholinesterase (ChE) Isoform Comparison

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